1987
DOI: 10.1111/j.1439-0434.1987.tb04380.x
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Inhibition of Plant Viruses by Human Gamma Interferon

Abstract: In order to evaluate the inhibitory effect induced by gamma interferon (Hu g IFN) on plant viruses, pre‐inoculation treatments (brushing the leaves) were carried out in two different plant‐virus systems: D. stramonium* TMV and G. globosa* PVX. Results showed that Hu g IFN induced a higher inhibitory effect (IP = 90%) in D. stramonium* TMV system (Table 1). Comparing the antiviral effect of the three IFNs: gamma, alpha and beta‐like interferons, it was verified that Hu g IFN was more effective than the other tw… Show more

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Cited by 10 publications
(4 citation statements)
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“…The resemblance ofAVF to IFN has been discussed (7) and antiviral activity of human IFNs in plants has also been reported (10)(11)(12)(13)(14). The AVFs isolated in this study presumably fold to create sites recognized by antibodies to human IFN-,l and this may also explain the antiviral activity of human IFN in plants.…”
Section: Discussionsupporting
confidence: 51%
See 1 more Smart Citation
“…The resemblance ofAVF to IFN has been discussed (7) and antiviral activity of human IFNs in plants has also been reported (10)(11)(12)(13)(14). The AVFs isolated in this study presumably fold to create sites recognized by antibodies to human IFN-,l and this may also explain the antiviral activity of human IFN in plants.…”
Section: Discussionsupporting
confidence: 51%
“…The possible activity of human IFNs in plants was investigated. Indeed, in several studies, human IFNs inhibited the multiplication of TMV and other plant viruses (10)(11)(12)(13)(14); however, some other laboratories failed to observe antiviral activity of human IFN in plants (15,16). IFN-induced oligoadenylates as well as synthetic 2'-5'-oligoadenylates also inhibited TMV multiplication in plants (17).…”
mentioning
confidence: 99%
“…Quite unexpected in this context has been the report [32] that human IFN2 suppresses the reproduction of tobacco mosaic virus (TMV) in tobacco plants. Subsequently it has been shown that human IFNs can also inhibit the accumulation of some other plant viruses [16,30,41]. As to 2-5A, they were also inhibitory to TMV reproduction in plants [7].…”
Section: Introductionmentioning
confidence: 99%
“…Щå ó 1982 ð. бóëî з'ÿñîâàíî, щî ³íòåðфåðîí ëюäèíè є àêòèâíèì пðîòè â³ðóñíèх ³íфåêö³é ðÿäó ðîñëèí [11]. Пðîâåäåí³ ó пîäàëüшîìó äîñë³äжåííÿ пîêàзàëè, щî ó ð³зíèх ðîñëèííèх ñèñòåìàх ëюäñüêèé ³íòåðфåðîí ìîжå бóòè àêòèâíèì [14], îäíàê ìîжëèâà ³ â³äñóòí³ñòü зàхèñíîгî åфåêòó ³íòåðфåðîíó ó ðîñëèíàх пðè їх óðàжåíí³ ф³òîâ³ðóñàìè [5,7,15]. Îñê³ëüêè âêàзàí³ äîñë³äжåííÿ пðîâåäåíî íà ð³зíèх âèäàх ðîñëèí, ñòàíîâèòü ³íòåðåñ ðîзшèðèòè їх êîëî з ìåòîю âèзíà÷åííÿ òîгî, ÷è є âèäîñпåöèф³÷íèì пîзèòèâíèé àбî íåгàòèâíèé пðîòèâ³ðóñíèé åфåêò ³íòåðфåðîíó.…”
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