Inhibition of Platelet Aggregation by Inhaled Nitric Oxide in Patients with Acute Respiratory Distress Syndrome

Samama, Charles Marc; Diaby, M.; Fellahi, Jean-Luc; Mdhafar, Ayoub; Eyraud, Daniel; Arock, M.; Guillosson, Jean‐Jacques; Coriat, Pierre; Rouby, Jean‐Jacques

doi:10.1097/00000542-199507000-00007

Cited by 190 publications

(49 citation statements)

References 22 publications

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“…19,25,26 In this study, iNO therapy had a significant effect on BBB dysfunction as measured by EB extravasation, so the shown reduction of brain water content is most probably because of a combination of reduction of vasogenic and cytotoxic edema formation. Furthermore, NO inhalation has been shown to exert anti-platelet activity [38][39][40] and to act anti-inflammatorily. 29,41 We previously showed that microthrombus formation occurs in our model of murine CCI and further deteriorates CBF; 42 in the same study leukocyte-platelet aggregates were detected in cerebral venules.…”

Section: Discussionmentioning

confidence: 99%

Inhaled Nitric Oxide Reduces Secondary Brain Damage after Traumatic Brain Injury in Mice

Terpolilli¹,

Kim²,

Thal³

et al. 2012

J Cereb Blood Flow Metab

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Ischemia, especially pericontusional ischemia, is one of the leading causes of secondary brain damage after traumatic brain injury (TBI). So far efforts to improve cerebral blood flow (CBF) after TBI were not successful because of various reasons. We previously showed that nitric oxide (NO) applied by inhalation after experimental ischemic stroke is transported to the brain and induces vasodilatation in hypoxic brain regions, thus improving regional ischemia, thereby improving brain damage and neurological outcome. As regional ischemia in the traumatic penumbra is a key mechanism determining secondary posttraumatic brain damage, the aim of the current study was to evaluate the effect of NO inhalation after experimental TBI. NO inhalation significantly improved CBF and reduced intracranial pressure after TBI in male C57 Bl/6 mice. Long-term application (24 hours NO inhalation) resulted in reduced lesion volume, reduced brain edema formation and less blood-brain barrier disruption, as well as improved neurological function. No adverse effects, e.g., on cerebral auto-regulation, systemic blood pressure, or oxidative damage were observed. NO inhalation might therefore be a safe and effective treatment option for TBI patients.

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Section: Discussionmentioning

confidence: 99%

Inhaled Nitric Oxide Reduces Secondary Brain Damage after Traumatic Brain Injury in Mice

Terpolilli¹,

Kim²,

Thal³

et al. 2012

J Cereb Blood Flow Metab

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“…Human SMCs were dyed by DiI before seeding onto each film in 48-well plates at a density of 2×10 4 per well with 200 μmol L 1 GSNO and 200 μmol L 1 GSH for 2 h at 37°C. The adhered cells were fixed in 4% paraformaldehyde for 10 min and observed with inverted fluorescence microscope.…”

Section: Smcs Adhesionmentioning

confidence: 99%

“…5×10 4 SMCs with 200 μmol L 1 GSNO and 200 μmol L 1 GSH were seeded onto each film and cultured for 4 h at 37°C. The cells were then stained with FITC-labeled phalloidin and observed under confocal laser scanning microscopy (CLSM; TCS SP5; Leica, Germany), or fixed in 2.5% glutaraldehyde overnight and dehydrated in gradient ethanol for SEM observation.…”

Section: Smcs Spreadingmentioning

confidence: 99%

Construction and evaluation of nitric oxide generating vascular graft material loaded with organoselenium catalyst via layer-by-layer self-assembly

Chen

Gao

et al. 2015

Sci. China Life Sci.

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A new biomimetic material for artificial blood vessel with in situ catalytic generation of nitric oxide (NO) was prepared in this study. Organoselenium immobilized polyethyleneimine as NO donor catalyst and sodium alginate were alternately loaded onto the surface of electrospun polycaprolactone matrix via electrostatic layer-by-layer self-assembly. This material revealed significant NO generation when contacting NO donor S-nitrosoglutathione (GSNO). Adhesion and spreading of smooth muscle cells were inhibited on this material in the presence of GSNO, while proliferation of endothelial cells was promoted. In vitro platelet adhesion and arteriovenous shunt experiments demonstrated good antithrombotic properties of this material, with inhibited platelet activation and aggregation, and prevention of acute thrombosis. This study may provide a new method of improving cellular function and antithrombotic property of vascular grafts. nitric oxide, catalytic generation, electrospinning, vascular graft, biocompatibility Citation:An J, Chen SY, Gao JC, Zhang X, Wang YY, Li YD, Mikhalovsky S, Kong DL, Wang SF. Construction and evaluation of nitric oxide generating vascular graft material loaded with organoselenium catalyst via layer-by-layer self-assembly. Sci China Life Sci, 2015, 58: 765 -772,

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“…iNO is associated with increased bleeding time and inhibition of platelet aggregation in adults. 29,30 A Cochrane review of randomized studies of iNO in the near-term infants did not find an association between the use of iNO and bleeding events. 18 …”

Section: Left Ventricular Dysfunctionmentioning

confidence: 99%

Role of iNO in the modulation of pulmonary vascular resistance

Bin‐Nun

Schreiber

2008

J Perinatol

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Inhaled nitric oxide (iNO) has quickly become a standard therapy for term and near-term infants with hypoxic respiratory failure and persistent pulmonary hypertension. Its effect on the lung is believed to be through the stimulation of soluble guanylyl cyclase and the increased production of cyclic guanosine 3 0 ,5 0 -monophosphate (cGMP). However, in addition to pulmonary vasodilation and a decrease in pulmonary vascular resistance, nitric oxide (NO) shows several additional potential beneficial effects on the lung. This article reviews NO mechanisms of action, early clinical trial of iNO and clinical aspects for the use of iNO in acute respiratory failure of the term and near-tem neonates.

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Inhibition of Platelet Aggregation by Inhaled Nitric Oxide in Patients with Acute Respiratory Distress Syndrome

Cited by 190 publications

References 22 publications

Inhaled Nitric Oxide Reduces Secondary Brain Damage after Traumatic Brain Injury in Mice

Inhaled Nitric Oxide Reduces Secondary Brain Damage after Traumatic Brain Injury in Mice

Construction and evaluation of nitric oxide generating vascular graft material loaded with organoselenium catalyst via layer-by-layer self-assembly

Role of iNO in the modulation of pulmonary vascular resistance

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