Inhibition of platelet aggregation in whole blood by alcohol

Duarte, Armida P. Torres; Dong, Quan; Young, J.; Abi-Younes, Sylvie; Myers, Adam K.

doi:10.1016/0049-3848(95)00039-9

Cited by 51 publications

(31 citation statements)

References 23 publications

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“…Alcohol consumption is also associated with decreased platelet aggregation, 40 decreased fibrinogen levels, 41 increased concentration of tissue plasminogen activator, 42,43 and enhanced insulin sensitivity. 44 Wine also contains phenolic compounds with antioxidant properties, 45 and consumption of polyphenols from other sources is associated with a decreased risk of cardiovascular disease.…”

Section: Djoussé Et Al Alcohol and Stroke 909mentioning

confidence: 99%

Alcohol Consumption and Risk of Ischemic Stroke

Djoussé

Ellison

Beiser

et al. 2002

Stroke

136

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Background and Purpose-Stroke is a major cause of death in the United States. The association between alcohol consumption and ischemic stroke (IS) remains controversial. Methods-We used data collected on participants in the Framingham Study to assess the association between total alcohol intake and type of alcoholic beverage and development of IS, overall and according to age. Results-A total of 196 men and 245 women developed IS during three 10-year follow-up periods. In the categories of never drinkers, drinkers of 0.1 to 11, 12 to 23, and Ն24 g/d of ethanol (a "typical drink" is Ϸ12 g of ethanol), and former drinkers of 0.1 to 11 and Ն12 g/d, crude incidence rates of IS were 6.5, 5.9, 4.9, 5.0, 6.7, and 17.8 cases per 1000 person-years, respectively, for men and 5.9, 4.1, 4.1, 4.3, 8.3, and 7.1, respectively, for women. Overall, compared with never drinkers in a multivariate Cox regression, current alcohol consumption was not related significantly to IS in either sex. Former drinking of Ն12 g/d of alcohol was associated with a 2.4 times higher risk of IS among men but not among women. When stratified by age, alcohol intake was associated with lower risk of IS among subjects aged 60 to 69 years.In beverage-specific analysis, only wine consumption was related to a decreased risk of IS. Conclusions-Our data showed no significant association between total alcohol and IS overall but showed a protective effect of alcohol among subjects aged 60 to 69 years.

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Section: Djoussé Et Al Alcohol and Stroke 909mentioning

confidence: 99%

Alcohol Consumption and Risk of Ischemic Stroke

Djoussé

Ellison

Beiser

et al. 2002

Stroke

136

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“…Previous studies have demonstrated beneficial effects of alcohol on high-density lipoprotein cholesterol, 26,27 insulin sensitivity, 28,29 inflammation and endothelial function, 30 coagulation factors, 31 and atrial natriuretic peptide, 16 -18 a cardiac hormone that plays a role in volume homeostasis. Consequently, several studies have reported that moderate alcohol intake may lower the risk of myocardial infarction and fatal coronary events.…”

Section: Discussionmentioning

confidence: 99%

Alcohol Consumption and Risk of Heart Failure in the Physicians’ Health Study I

2007

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Background-Heart failure (HF) is the leading cause of hospitalization among the elderly, and 1 in 5 adults aged 40 years will develop HF in their lifetime. Data on the effects of moderate alcohol consumption on the risk of HF have been sparse and inconsistent. This study sought to evaluate the association between moderate alcohol consumption and incident HF. Methods and Results-A total of 21 601 participants of the Physicians' Health Study I who were free of HF and provided data on alcohol intake at baseline were prospectively followed up from 1982 to 2005. Incident HF cases were ascertained through annual follow-up questionnaires and validated with the use of Framingham criteria. During an average follow-up of 18.4 years, 904 incident cases of HF occurred. The crude incidence rates of HF were 25.0, 20.0, 24.3, and 20.6 cases per 10 000 person-years for alcohol categories of Ͻ1, 1 to 4, 5 to 7, and Ͼ7 drinks per week, respectively. Corresponding hazard ratios (95% CI) were 1.0 (reference), 0.90 (0.76 to 1.07), 0.84 (0.71 to 0.99), and 0.62 (0.41 to 0.96), respectively, with P for trendϭ0.012 adjusted for age, body mass index, smoking, and history of valvular heart disease. There was no evidence for a strong association between moderate alcohol consumption and HF without antecedent coronary artery disease. Conclusions-Although heavy drinking should be discouraged, our data indicate that moderate drinking may lower the risk of HF. The lack of an association between moderate alcohol intake and HF without antecedent coronary artery disease suggests that possible benefits of moderate drinking on HF may be mediated through beneficial effects of alcohol on coronary artery disease.

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“…Alcohol might affect hemostasis by inducing dietary deficiencies which impair megakaryocyte maturation, inhibit platelet aggregation, and reduce global fibrinolytic capacity [51][52][53][54][55]. Definite evidence for impaired fibrinolysis in alcohol misusers is still needed, as previous studies assessed single components of the fibrinolytic system.…”

Section: Factors Tipping the Hemostatic Balance In Cirrhosismentioning

confidence: 99%

Hemostatic balance in patients with liver cirrhosis: Report of a consensus conference

Andriulli

Tripodi

Angeli

et al. 2016

Digestive and Liver Disease

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a b s t r a c tPatients with cirrhosis present with hemostatic alterations secondary to reduced availability of procoagulant and anti-coagulant factors. The net effect of these changes is a rebalanced hemostatic system. The Italian Association of the Study of the Liver (AISF) and the Italian Society of Internal Medicine (SIMI) promoted a consensus conference on the hemostatic balance in patients with cirrhosis. The consensus process started with the review of the literature by a scientific board of experts and ended with a formal consensus meeting in Rome in December 2014. The statements were graded according to quality of evidence and strength of recommendations, and approved by an independent jury. The statements presented here highlight strengths and weaknesses of current laboratory tests to assess bleeding and thrombotic risk in cirrhotic patients, the pathophysiology of hemostatic perturbations in this condition, and outline the optimal management of bleeding and thrombosis in patients with liver cirrhosis.

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Inhibition of platelet aggregation in whole blood by alcohol

Cited by 51 publications

References 23 publications

Alcohol Consumption and Risk of Ischemic Stroke

Alcohol Consumption and Risk of Ischemic Stroke

Alcohol Consumption and Risk of Heart Failure in the Physicians’ Health Study I

Hemostatic balance in patients with liver cirrhosis: Report of a consensus conference

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