Inhibition of polymorphonuclear leucocyte phagocytosis by Porphyromonas gingivalis culture products in patients with adult periodontitis

Wilton, James; Hurst, T. J.; Scott, Emily E.

doi:10.1016/0003-9969(93)90134-8

Cited by 18 publications

(19 citation statements)

References 17 publications

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“…Interestingly, there has been some evidence that P. gingivalis ’ products recovered from its growth culture, even alter neutrophil morphology . One bacterial product, trypsin‐like protease (TLPase), plays a role in inhibition of phagocytosis . This inhibitory effect is more profound in neutrophils from periodontitis patients than healthy controls which may point to added effects from other pathogens and/or systemic alteration to the host's neutrophils .…”

Section: Neutrophils and Periodontal Disease: The Results Of A Discordmentioning

confidence: 99%

“…One bacterial product, trypsin‐like protease (TLPase), plays a role in inhibition of phagocytosis . This inhibitory effect is more profound in neutrophils from periodontitis patients than healthy controls which may point to added effects from other pathogens and/or systemic alteration to the host's neutrophils . Neutrophils from periodontal disease patients are impaired in their ability to phagocytose bacteria, and TLPase from P. gingivalis may be one of the causes of this .…”

Section: Neutrophils and Periodontal Disease: The Results Of A Discordmentioning

confidence: 99%

“…This inhibitory effect is more profound in neutrophils from periodontitis patients than healthy controls which may point to added effects from other pathogens and/or systemic alteration to the host's neutrophils . Neutrophils from periodontal disease patients are impaired in their ability to phagocytose bacteria, and TLPase from P. gingivalis may be one of the causes of this . Additionally, TLPase has been shown to increase the generation of superoxide anions and cleave the neutrophil formyl peptide receptor .…”

Section: Neutrophils and Periodontal Disease: The Results Of A Discordmentioning

confidence: 99%

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Human neutrophils and oral microbiota: a constant tug‐of‐war between a harmonious and a discordant coexistence

Uriarte

Edmisson

Jimenez-Flores

2016

Immunological Reviews

100

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Summary Neutrophils are a major component of the innate host response, and the outcome of the interaction between the oral microbiota and neutrophils is a key determinant of oral health status. The composition of the oral microbiome is very complex and different in health and disease. Neutrophils are constantly recruited to the oral cavity, and their protective role is highlighted in cases where their number or functional responses are impeded, resulting in different forms of periodontal disease. Periodontitis, one of the more severe and irreversible forms of periodontal disease, is a microbial-induced chronic inflammatory disease that affects the gingival tissues supporting the tooth. This chronic inflammatory disease is the result of a shift of the oral bacterial symbiotic community to a dysbiotic more complex community. Chronic inflammatory infectious diseases such as periodontitis can occur because the pathogens are able to evade or disable the innate immune system. In this review, we discuss how human neutrophils interact with both the symbiotic and the dysbiotic oral community; an understanding of which is essential to increase our knowledge of the periodontal disease process.

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Section: Neutrophils and Periodontal Disease: The Results Of A Discordmentioning

confidence: 99%

Section: Neutrophils and Periodontal Disease: The Results Of A Discordmentioning

confidence: 99%

Section: Neutrophils and Periodontal Disease: The Results Of A Discordmentioning

confidence: 99%

See 1 more Smart Citation

Human neutrophils and oral microbiota: a constant tug‐of‐war between a harmonious and a discordant coexistence

Uriarte

Edmisson

Jimenez-Flores

2016

Immunological Reviews

100

View full text Add to dashboard Cite

show abstract

“…Gingipains and other P. gingivalis products depress PMN phagocytosis in both periodontitis patients and healthy persons. However, the PMN of the periodontitis patients are more susceptible to inhibition by the culture products than the healthy controls [17].…”

Section: Discussionmentioning

confidence: 99%

Phagocytosis of Periodontopathogenic Bacteria by Crevicular Granulocytes Is Depressed in Progressive Periodontitis

Eick¹,

Pfister²,

Sigusch³

et al. 2000

Infection

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“…Neutrophils are the predominant line of defense in the gingival crevice. P. gingivalis culture products have been reported to interfere with neutrophil elimination of the organism by causing inappropriate stimulation of the neutrophil, enhancing complement receptor 3 expression, and inhibiting phagocytosis (40,41).…”

mentioning

confidence: 99%

Lipopolysaccharidefrom the Periodontal PathogenPorphyromonas gingivalisPrevents Apoptosis of HL60-Derived Neutrophils InVitro

Murray

Wilton

2003

Infect Immun

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Lipopolysaccharide (LPS) fromPorphyromonas gingivalis prevented apoptosis of HL60-derived neutrophils, which could not be restored upon the addition of interleukin-10. Signaling of P. gingivalis LPS through Toll-like receptor 2 (TLR2), not TLR4, may account for the inhibiting effect of P. gingivalis LPS on apoptosis and provide a mechanism for the development of destructive periodontal inflammation.

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Inhibition of polymorphonuclear leucocyte phagocytosis by Porphyromonas gingivalis culture products in patients with adult periodontitis

Cited by 18 publications

References 17 publications

Human neutrophils and oral microbiota: a constant tug‐of‐war between a harmonious and a discordant coexistence

Human neutrophils and oral microbiota: a constant tug‐of‐war between a harmonious and a discordant coexistence

Phagocytosis of Periodontopathogenic Bacteria by Crevicular Granulocytes Is Depressed in Progressive Periodontitis

Lipopolysaccharidefrom the Periodontal PathogenPorphyromonas gingivalisPrevents Apoptosis of HL60-Derived Neutrophils InVitro

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