Inhibition of precancerous lesions development in kidneys by chrysin via regulating hyperproliferation, inflammation and apoptosis at pre clinical stage

Rashid, Summya; Nafees, Sana; Vafa, Abul; Afzal, Shekh Mohammad; Ali, Nemat; Rehman, Muneeb U.; Hasan, Syed Kazim; Siddiqi, Aisha; Barnwal, Preeti; Majed, Ferial; Sultana, Sarwat

doi:10.1016/j.abb.2016.07.004

Cited by 24 publications

(22 citation statements)

References 28 publications

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“…Rehman et al (2014) and a few others have reported an increase in the tissue levels of the inflammatory mediators, along with the infiltration of cells, highlighting the role of inflammation in cisplatin-induced organ injury [70][71][72]. Nuclear factor kappa-B (NF-κB) is a well-known redox-sensitive transcription factor, and its activation is important for downstream inflammatory mediators such as TNF-α, IL-6, and so on, playing an important role in acute inflammatory processes and conditions linked to oxidative stress [73,74]. The dormant form of NF-κB is present in the cytoplasm attached to the inhibitory protein subunit IkB, which belongs to the transcriptional activator proteins of Rel family.…”

Section: Discussionmentioning

confidence: 99%

“…The dormant form of NF-κB is present in the cytoplasm attached to the inhibitory protein subunit IkB, which belongs to the transcriptional activator proteins of Rel family. ROS or other external stimuli facilitate the phosphorylation of IkB in the presence of IkB kinases and causes its disassociation leading to translocation from cytoplasm into nucleus [14,73,75].…”

Section: Discussionmentioning

confidence: 99%

“…With the activation of NF-κB by cisplatin, cytokine-like TNF-α can mediate the release of a considerable amount of IL-6, leading to inflammatory conditions. Naturally occurring compounds, which are the inhibitors of IL-6 and TNF-α, have been used to counter anticancer drug toxicity [73,99,100]. Myricetin treatment was effective in attenuating cisplatin-induced levels of TNF-α and IL-6 ( Figure 5 [6,11,24,66].…”

Section: Discussionmentioning

confidence: 99%

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Myricetin Abrogates Cisplatin-Induced Oxidative Stress, Inflammatory Response, and Goblet Cell Disintegration in Colon of Wistar Rats

Rehman

Rather

2019

Plants

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Cisplatin [cis-diamminedichloroplatinum II] is an extensively prescribed drug in cancer chemotherapy; it is also useful for the treatment of diverse types of malignancies. Conversely, cisplatin is associated with a range of side effects such as nephrotoxicity, hepatotoxicity, gastrointestinal toxicity, and so on. Myricetin (3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4chromenone) is a very common natural flavonoid found in fruits, tea, and plants. It has been found to have high-value pharmacological properties and strong health benefits. To examine the role of myricetin in colon toxicity induced by cisplatin, we conducted a concurrent prophylactic study in experimental animals that were treated orally with myricetin for 14 days at two doses—25 and 50 mg/kg of body weight. On the 14th day, a single intraperitoneal injection of cisplatin (7.5 mg/kg body weight) was administered in all groups except control. The effects of myricetin in cisplatin-induced toxicity in the colon were assessed in terms of antioxidant status, phase-II detoxification enzymes, the level of inflammatory markers, and goblet cell disintegration. Myricetin was found to restore the level of all the antioxidant enzymes analyzed in the study. In addition, the compound ameliorated cisplatin-induced lipid peroxidation, increase in xanthine oxidase activity, and phase-II detoxifying enzyme activity. Myricetin also attenuated deteriorative effects induced by cisplatin by regulating the level of molecular markers of inflammation (NF-κB, Nrf-2, IL-6, and TNF-α), restoring Nrf-2 levels, and controlling goblet cell disintegration. The current study reinforces the conclusion that myricetin exerts protection in colon toxicity via up-regulation of inflammatory markers, improving anti-oxidant status, and protecting tissue damage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Myricetin Abrogates Cisplatin-Induced Oxidative Stress, Inflammatory Response, and Goblet Cell Disintegration in Colon of Wistar Rats

Rehman

Rather

2019

Plants

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“…Propolis has modulatory action on murine peritoneal macrophages, increasing their microbicidal activity and stimulant action on antibody production (Sforcin, 2007). The synergistic effects of wide range of compounds present in propolis are the results of antioxidants activity (Hegazi and Abd Al Hady, 2009) and hepatocytes protection (ElKhatib et al, 2002) and anti-inflammatory (Rashid et al, 2016).…”

Section: Resultsmentioning

confidence: 99%

Egyptian Propolis 12: Influence of Propolis on Cytokines of Toxoplasma gondii Infected Rats

Hegazı¹,

Guthami²,

Gethami³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

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“…To separate the nuclear debris, centrifugation was done at 700 g in cooling centrifuge to homogenized colon for 10 minutes. PMS in form of aliquot so obtained was used as repertoire of numerous enzymes [10].…”

Section: Post-mitochondrial Supernatant (Pms) Preparationmentioning

confidence: 99%

Anti-Cancer Activity of Piperine Against Colon Carcinogenesis Via Modulation of NF-κB/Nrf-2/Keap1/HO-1 Signalling Pathways

Rehman¹,

Rashid²,

Arafah³

et al. 2020

Preprint

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Background: Colon cancer is the most common cancer in men and women globally, killing millions of people annually. Though widespread development has been made in the management of colorectal cancer, still there is an urgency to find novel targets for effective treatment of these patients. Piperine is an alkaloid found in black pepper having anticancer, anti-oxidant and anti-inflammatory activities. Nuclear factor-erythroid 2–kelch-like ECH-associated protein 1(Nrf-2/Keap1)/ Heme-oxygenase1 (HO-1) signaling pathway plays a vital part in shielding cells from the injury of intracellular oxidative stress and inflammation. A potential cross-talk between Nrf-2 and NF-κB pathways is recognized during cancerous growth and expansion. We studied this pathway extensively in the present study to discover novel targets in prevention of chemically induced colon cancer with piperine.Results: We found that NF-κB inhibition occurs by the activation of Nrf-2 blocks downstream inflammatory mediators/cytokines (TNF-α, IL-6, IL-1β, Cox-2, PGE2, iNOS, NO, MPO) and triggers antioxidant response machinery (HO-1, NQO-1 GSH, GR, GPx, CAT, SOD), scavenges ROS, decreases lipid peroxidation. Histological findings further validated our defensive effects of piperine on colon carcinogenesis. Piperine down-regulates CEA, MDF and ACF, markers of precancerous lesions in colon.Conclusion: Our results indicate that piperine may be an effective molecule for the prophylactic treatment of colon carcinogenesis by targeting NF-κB/Nrf-2/Keap1/HO-1 pathway as a progressive strategy in preclusion and effective treatment of colorectal cancer.

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Inhibition of precancerous lesions development in kidneys by chrysin via regulating hyperproliferation, inflammation and apoptosis at pre clinical stage

Cited by 24 publications

References 28 publications

Myricetin Abrogates Cisplatin-Induced Oxidative Stress, Inflammatory Response, and Goblet Cell Disintegration in Colon of Wistar Rats

Myricetin Abrogates Cisplatin-Induced Oxidative Stress, Inflammatory Response, and Goblet Cell Disintegration in Colon of Wistar Rats

Egyptian Propolis 12: Influence of Propolis on Cytokines of Toxoplasma gondii Infected Rats

Anti-Cancer Activity of Piperine Against Colon Carcinogenesis Via Modulation of NF-κB/Nrf-2/Keap1/HO-1 Signalling Pathways

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