Inhibition of protein glycation, antioxidant and antiproliferative activities of Carpobrotus edulis extracts

Hafsa, Jawhar; Hammi, Khaoula Mkadmini; Khedher, Mohamed Raâfet Ben; Smach, Mohamed Ali; Charfeddine, Bassem; Limem, Khalifa; Majdoub, Hatem

doi:10.1016/j.biopha.2016.11.046

Cited by 42 publications

(38 citation statements)

References 30 publications

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“…12,[36][37][38] Similarly, C. edulis has been reported to contain lots of antioxidants, impede protein glycation as well as cell proliferation with inhibition of the P-glycoprotein efflux pump as a mechanism of action. 32,34 Together, these results show that S. frutescens and C. edulis inhibits proliferation of malignant glioblastoma cells and most importantly, the U87 cells were more sensitive due to the lower IC50 values obtained.…”

Section: S Frutescens and C Edulis Induce Cytotoxicity In Malignantmentioning

confidence: 76%

“…A possible explanation for this activity could be as a result of the chemical composition of these extracts which have been reported to show anti-cancer activity. 32,[36][37][38] Further investigations are required to elucidate the molecular mechanisms of action responsible for the anti-cancer activity of these extracts.…”

Section: Resultsmentioning

confidence: 99%

“…Data generated from this study is consistent with previous findings which show that S. frutescens and C. edulis induce antiproliferative effects in cancer cells. 17,21,32,34 The cytotoxicity observed in these study could be in part as a result of the chemical constituents of the extracts tested. For S. frutescens, it has been reported that the plant is rich in amino acids including l-arginine and l-canavanine as well as other components like pinitol, flavonol glycosides and triterpenoid saponins which have been demonstrated to possess anti-cancer activity.…”

Section: S Frutescens and C Edulis Induce Cytotoxicity In Malignantmentioning

confidence: 87%

“…27,[29][30][31][32][33] Its anti-cancer activity was first reported when C. edulis inhibited P-glycoprotein, which is known to promote drug resistance in mouse lymphoma as well as antiproliferative activities in HCT116 colorectal carcinoma cells. 32,34 One of the hallmarks of cancer is the rapid proliferation of cells due to oncogenic factors, thus, inhibition of cell proliferation is critical in the development of an anti-cancer agent. 35 More so, there is a knowledge gap on the anti-cancer activities of these medicinal plants (S. frutescens and C.edulis) in glioblastoma.…”

Section: Introductionmentioning

confidence: 99%

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Preliminary Cytotoxic Activity of Sutherlandia frutescens and Carpobrotus edulis on Malignant glioblastoma Cells

Omoruyi¹,

Enogieru²,

Ekpo³

2019

TJNPR

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Glioblastoma (GBM) is the most common and aggressive intracranial tumour with limited therapeutic options due to their high tumour vasculature and invasiveness. Treatment of GBM includes surgery, followed by chemotherapy and radiotherapy. Despite these treatment options, tumour relapse is still a major issue hence the need for cheap and effective treatment strategies. South Africa is endowed with numerous medicinal plants including Sutherlandia frutescens (S. frutescens) and Carpobrotus edulis (C.edulis), which has been previously reported for their antioxidant and neuroprotective activities. Accordingly, this study was designed to investigate the cytotoxicity of both medicinal plants (S. frutescens and C. edulis) in malignant human GBM cells U251 and U87. The cytotoxic activity was measured using the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide (MTT) assay while the effect of extracts on colony formation and survival was determined using clonogenic assay. Results show that both S. frutescens and C .edulis induced cytotoxicity in both GBM cells and inhibit colony formation in U251 cells. These findings show that extracts from these plants may be useful in the treatment of GBM and thus requires further investigations into their mechanisms of action as well as isolation of bioactive components responsible for these activities.

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Section: S Frutescens and C Edulis Induce Cytotoxicity In Malignantmentioning

confidence: 76%

Section: Resultsmentioning

confidence: 99%

Section: S Frutescens and C Edulis Induce Cytotoxicity In Malignantmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preliminary Cytotoxic Activity of Sutherlandia frutescens and Carpobrotus edulis on Malignant glioblastoma Cells

Omoruyi¹,

Enogieru²,

Ekpo³

2019

TJNPR

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“…All the irrelevant and duplicate topics or results were excluded. The literature search was concluded through 76 full-length research articles (reference lists which include research articles on traditional and medicinal prop- [13][14] erties, studies related to diabetic retinopathy both in-vitro and in-vivo. No randomized controlled trials conducted on the human population were identified.…”

Section: Methodsmentioning

confidence: 99%

Exploring the Potential of Traditional Herbs in the Management of Diabetic Retinopathy: An Overview

Singh

Kushwaha

Gupta³

2020

Drug Res (Stuttg)

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AbstractDiabetic retinopathy is a microvascular complication in diabetes that affects eyes and is responsible for most visual impairment in diabetic patients. Diabetic retinopathy affects up to 80% of those who have had diabetes for 20 years or more. At least 90% of new cases could be reduced with proper treatment and monitoring of the eyes. The longer a person has diabetes, the higher his or her chances of developing diabetic retinopathy. Hence, it compels need for its prevention and cure. There is an increasing interest in natural products in pharmacotherapy as the chemical diversity of natural products has better matches than the diversity of synthetic compounds. The current review summarises the potential of leading traditional herbs like Azadirachta indica, Ginkgo biloba, Anisodus tanguticus, Pinus pinaster, Salvia miltiorrhiza, Stephania tetrandra and Gymnema sylvestre in the management and potential reversal of DR-related pathogenesis. It also discusses the probable mechanism of actions, which are based on epidemiological, in-vitro and in-vivo studies carried out within past few years. Graphical Abstract.

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Characterization of polysaccharide fractions from fruit of Actinidia arguta and assessment of their antioxidant and antiglycated activities

Zhu

Zhang

Wang

et al. 2019

Carbohydrate Polymers

165

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Inhibition of protein glycation, antioxidant and antiproliferative activities of Carpobrotus edulis extracts

Cited by 42 publications

References 30 publications

Preliminary Cytotoxic Activity of Sutherlandia frutescens and Carpobrotus edulis on Malignant glioblastoma Cells

Preliminary Cytotoxic Activity of Sutherlandia frutescens and Carpobrotus edulis on Malignant glioblastoma Cells

Exploring the Potential of Traditional Herbs in the Management of Diabetic Retinopathy: An Overview

Characterization of polysaccharide fractions from fruit of Actinidia arguta and assessment of their antioxidant and antiglycated activities

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