Inhibition of Pseudomonas aeruginosa Quorum Sensing by Curcuma xanthorrhiza Roxb. Extract

Othman, Ahmad Fiqri Mustaqim; Rukayadi, Yaya; Radu, Son

doi:10.22207/jpam.13.3.05

Cited by 4 publications

(5 citation statements)

References 86 publications

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“…However, certain phenolic compounds amongst other metabolites in these plants could be responsible for the observed anti-QS activity. Naturally occurring phenolic compound p-coumaric acid has already been shown to interact with bacterial quorum sensing, sometimes by triggering or by inhibiting the QS-process system (Othman et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Assessment of in vitro activities and chemical profiling of Senecio hoggariensis growing in Algerian Sahara

et al. 2022

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Abstract. Arab Y, Sahin B, Ceylan O, Zellagui A, Olmez OT, Kucukaydin S, Tamfu AN, Ozturk M, Gherraf N. 2022. Assessment of in vitro activities and chemical profiling of Senecio hoggariensis growing in Algerian Sahara. Biodiversitas 23: 3498-3506. The in vitro antioxidant, anticholinesterase, tyrosinase inhibitory, antibiofilm, and anti-quorum sensing activities of the ethyl acetate extract of Senecio hoggariensis,growing in Algerian Sahara, were studied along with its chemical constituents using HPLC-DAD. The chromatographic analysisunveiled seven phenolic compounds, including p-coumaric acid as a major component. Additionally, the extract showed moderate DPPH radical scavenging activity, compared to known standards. At 200 ?g/mL, the extract disclosed equitable acetylcholinesterase (AChE), butyryl-cholinesterase (BChE) and tyrosinase inhibition rates with respective values of 37.01±1.48%, 18.87±4.18% and 45.99±1.81%. Likewise, the extract exhibited a good antibiofilm activity against Candida albicans ATCC 10239 biofilm production with an inhibition ratio of 59.56±0.40%, at 50µg/mL. The anti-quorum sensing by QS-regulated violacein pigment production inhibition test was determined using Chromobacterium violaceum CV026 and CV12472. The swarming motility inhibition assay was determined using Pseudomonas aeruginosa PA01. It is evident from the findings that Senecio hoggariensis could be considered potential antioxidant, anti-QS, and antibiofilm compounds. However, the origin of anti-biofilm and anti-quorum sensing activities of the ethyl acetate extract could be revealed by further studies on the mechanism of action of active compounds that can be isolated via activity-guided fractionation.

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Section: Discussionmentioning

confidence: 99%

Assessment of in vitro activities and chemical profiling of Senecio hoggariensis growing in Algerian Sahara

et al. 2022

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“…The study of the different types of turmeric species in the Zingiberaceae family [2][3][4]7] regarding the content of bioactive compounds suggests a growing trend in the production of curcumin in the coming years due to the development of new areas of use (Figure 2). Due to its antioxidant and anti-inflammatory properties, curcumin is presented in many specialized studies as a potential adjuvant for treating cancer [6] and neurodegenerative diseases [21].…”

Section: Methods Of Obtaining and Antiviral Antifungal And Antibacter...mentioning

confidence: 99%

“…Considering the epidemiological events caused by the appearance of the COVID-19 virus, in the last two years, there has been an intensification of studies on the methods to obtain [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] curcumin and its bioactivity properties [21][22][23][24][25][26][27][28][29][30]. If, in 2017, the global curcumin market was valued at USD 52.45 million, due to the diversification of application areas, it is estimated that the size of the global curcumin market will reach USD 151.9 million by 2027.…”

Section: Introductionmentioning

confidence: 99%

Curcumin: Modern Applications for a Versatile Additive

Raduly

Rădiţoiu

et al. 2021

Coatings

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The recent development of several methods for extracting curcumin from the root of the plant Curcuma longa has led to intensified research on the properties of curcumin and its fields of application. Following the studies and the accreditation of curcumin as a natural compound with antifungal, antiviral, and antibacterial properties, new fields of application have been developed in two main directions—food and medical, respectively. This review paper aims to synthesize the fields of application of curcumin as an additive for the prevention of spoilage, safety, and quality of food. Simultaneously, it aims to present curcumin as an additive in products for the prevention of bacterial infections and health care. In both cases, the types of curcumin formulations in the form of (nano)emulsions, (nano)particles, or (nano)composites are presented, depending on the field and conditions of exploitation or their properties to be used. The diversity of composite materials that can be designed, depending on the purpose of use, leaves open the field of research on the conditioning of curcumin. Various biomaterials active from the antibacterial and antibiofilm point of view can be intuited in which curcumin acts as an additive that potentiates the activities of other compounds or has a synergistic activity with them.

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“…However, it has been reported that C. xanthorrhiza extract has shown to inhibit acid production of S. mutans biofilm [53]. Moreover, C. xanthorrhiza extract is also reported to have anti-QS or quorum quenching activity [69]. The high level of tannin, phenol, phenolic compound in C. xanthorrhiza is suggested to precipitate the proteins that are vital for rhl system in Pseudomonas aeruginosa.…”

Section: Antibiofilmmentioning

confidence: 99%

“…The high level of tannin, phenol, phenolic compound in C. xanthorrhiza is suggested to precipitate the proteins that are vital for rhl system in Pseudomonas aeruginosa. By inhibiting the rhl system, the swarming activity of P. aeruginosa is inhibited, thus the QS will not take place [69,70]. Besides that, killing the cells by cell lysis will also degrade and detach the biofilm.…”

Section: Antibiofilmmentioning

confidence: 99%

Curcuma Xanthorrhiza Roxb. An Indonesia Native Medicinal Plant with Potential Antioral Biofilm Effect

Suniarti¹,

Puspitawati²,

Yanuar³

et al. 2022

Focus on Bacterial Biofilms

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Most common oral diseases are directly related to oral biofilm, a complex community of microorganisms inhibiting the oral cavity. Recent studies provide deeper knowledge on how free-floating bacteria form a structurally organized microecosystem and on its pathogenicity and its self-defense mechanisms; thus, creating an understanding of the challenges in eliminating oral biofilm and maintaining the balance of oral ecosystem. Chlorhexidine has been the standard oral antimicrobial agent for decades. However, studies showed that it is less effective against bacteria in the form of biofilm that leads to an ongoing search of another method to fight against biofilm, including the use of plant-derived compounds. Medicinal plants are known to contain secondary metabolites, which are not only important in protecting the plant from any harmful environment but also potential as antimicroorganism and antioral biofilm for humans. Curcuma xanthorrhiza Roxb., containing xanthorrhizol (XNT), an essential bioactive compound, is an Indonesian native medicinal plant proven to have antibacterial and antibiofilm activities by several in vitro studies. The understanding of biofilm formation, its resistance to common drugs, and the potential role of C. xanthorrhiza-derived compounds as antibacterial and antibiofilm may contribute to developing C. xanthorrhiza into the alternative weapon against oral biofilm-related diseases.

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Inhibition of Pseudomonas aeruginosa Quorum Sensing by Curcuma xanthorrhiza Roxb. Extract

Cited by 4 publications

References 86 publications

Assessment of in vitro activities and chemical profiling of Senecio hoggariensis growing in Algerian Sahara

Assessment of in vitro activities and chemical profiling of Senecio hoggariensis growing in Algerian Sahara

Curcumin: Modern Applications for a Versatile Additive

Curcuma Xanthorrhiza Roxb. An Indonesia Native Medicinal Plant with Potential Antioral Biofilm Effect

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