2013
DOI: 10.5012/bkcs.2013.34.12.3874
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Inhibition of PTPN2 by PTP inhibitor V

Abstract: Protein phosphorylation is closely linked to critical pathways in numerous human diseases, which is regulated by the coordinated activities of kinases and phosphatases.1 Protein phosphorylation occurs predominantly on serine, threonine, and tyrosine residues of proteins and plays important roles in the regulation of physiological processes including gene expression, proliferation, differentiation, cell cycle arrest, and apoptosis.2 About 30% of proteins are phosphorylated in the mammalian cell. In case of euka… Show more

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