Inhibition of rabbit PMN lipoxygenase activity by benoxaprofen

Walker, John R.; Dawson, W.

doi:10.1111/j.2042-7158.1979.tb13657.x

Cited by 97 publications

(28 citation statements)

References 9 publications

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“…Preliminary inhibition studies revealed that concentrations of up to 10HIM phenidone (IC50 =50 riM), 10 AM NDGA (IC50 = 70 DIM) and 100-1,000 tiM benoxaprofen (IC50>2000 rM) did not inhibit lipoxygenase activity. Benoxaprofen which has been claimed to be an inhibitor of both cyclo-oxygenases and lipoxygenases (Walker & Dawson, 1979;Dawson, 1980) did not exhibit any anti-soybean lipoxygenase activity; similar observations confirming the lack of an anti-lipoxygenase effect of benoxaprofen have recently been made by Verrando et al (1983).…”

Section: Footnote)supporting

confidence: 65%

Interactions of inhibitors of the lipoxygenase and cyclo‐oxygenase pathways with a supplementary binding site on soybean lipoxygenase

Baumann¹,

Baumann²,

Wurm³

1984

British J Pharmacology

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Section: Footnote)supporting

confidence: 65%

Interactions of inhibitors of the lipoxygenase and cyclo‐oxygenase pathways with a supplementary binding site on soybean lipoxygenase

Baumann¹,

Baumann²,

Wurm³

1984

British J Pharmacology

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“…1979; Walker & Dawson, 1979) also showed inhibitory activity. Five other conventional non-steroidal anti-inflammatory agents were tested and none showed any appreciable activity.…”

Section: Discussionmentioning

confidence: 99%

Calcium Ionophore A23187 Induces Release of Chemokinetic and Aggregating Factors From Polymorpho‐nuclear Leucocytes

Bray

Ford‐Hutchinson

Shipley

et al. 1980

British J Pharmacology

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Rat and human polymorphonuclear leucocytes (PMNs) when exposed to calcium ionophore A23187 10 μm release products which cause aggregation of rat PMNs and chemokinesis of human PMNs. Aggregating and chemokinetic activities are rapidly generated; maximal release occurs after 4 min, and can be detected in dilutions of the supernatant of up to 1:1000. Generation of aggregating and chemokinetic activities is inhibited by nordihydroguaiaretic acid 10−4 to 10−7 m, 5,8,11,14‐eicosatetraynoic acid 10−4 and 10−5 m, BW 755C 10−4 m and benoxaprofen 10−4 m, all compounds known to inhibit lipoxygenase pathways of arachidonic acid (AA) metabolism. Conventional non‐steroidal anti‐inflammatory agents, such as aspirin and indomethacin, inhibited little or not at all the generation of these activities. We conclude that the aggregating and chemokinetic activities induced by A23187 represent generation of biologically active products of lipoxygenase pathways of AA metabolism.

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“…Walker and Dawson (22) reported that benoxaprofen inhibited the rabbit neutrophil derived 5-LO activity. Harvey and Osborne (19) also demonstrated that the activity of 5-LO derived from guinea pig PMN was inhi bited by the drug.…”

Section: Resultsmentioning

confidence: 99%

Species difference of 5-lipoxygenase derived from polymorphonuclear leukocytes on sensitivity to drugs.

et al. 1989

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Abstract-Effects of 12 compounds including 5-lipoxygenase (5-LO) inhibitors and antiallergic drugs on the activity of 5-LO from the polymorphonuclear leukocytes (PMN) of guinea pigs, rats, rabbits, monkeys and humans were examined. The 5-LO activity was inhibited by the drugs according to the following orders of efficacy: Guinea pig 5-LO, 5-HDHDMF>TZI-2721 >NDGA>AA861 >FPL55712>isopro terenol; rat 5-LO, 5-HDHDMF>AA861 >TZI-2721 >NDGA>FPL55712>KP-136 >MCI-826>benoxaprofen;and rabbit 5-LO, 5-HDHDMF>TZI-2721 >NDGA> AA861 >FPL55712>KP-136>MCI-826.The 5-LO activity from the rhesus monkey was dose-dependently inhibited by only 3 compounds, 5-HDHDMF> NDGA>TZI-2721, in this order, but the other compounds, except for AA861, did not show any effect on this activity. In humans, 5-LO activity was inhibited in the following order: TZI-2721 >5-HDHDMF>NDGA>AA861 >FPL55712. From these results, it was strongly suggested that there is a species difference of this enzyme in its sensitivity to drugs.

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Inhibition of rabbit PMN lipoxygenase activity by benoxaprofen

Cited by 97 publications

References 9 publications

Interactions of inhibitors of the lipoxygenase and cyclo‐oxygenase pathways with a supplementary binding site on soybean lipoxygenase

Interactions of inhibitors of the lipoxygenase and cyclo‐oxygenase pathways with a supplementary binding site on soybean lipoxygenase

Calcium Ionophore A23187 Induces Release of Chemokinetic and Aggregating Factors From Polymorpho‐nuclear Leucocytes

Species difference of 5-lipoxygenase derived from polymorphonuclear leukocytes on sensitivity to drugs.

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