Inhibition of Red Cell Sequestration by Cortisone

Kaplan, Manuel E.; Jandl, James H.

doi:10.1084/jem.114.6.921

Cited by 34 publications

(13 citation statements)

References 49 publications

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“…Kaplan and Jandl (13) examined the clearance of antibody-coated cells in rats utilizing antisera prepared in rabbits and exposing the sensitized cells to fresh rat serum as 40% suspension prior to injection. They found that cortisone acetate therapy decreased sequestration of cells at all levels of sensitization studied.…”

Section: Discussionmentioning

confidence: 99%

Effects of Corticosteroids and Splenectomy on the Immune Clearance and Destruction of Erythrocytes

Atkinson¹,

Schreiber²,

Frank³

1973

J. Clin. Invest.

106

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Section: Discussionmentioning

confidence: 99%

Effects of Corticosteroids and Splenectomy on the Immune Clearance and Destruction of Erythrocytes

Atkinson¹,

Schreiber²,

Frank³

1973

J. Clin. Invest.

106

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“…The clearance rate of heat-damaged RBC from circulation was measured according to the method of Kaplan and Jandl [8]. The labeled RBC was heated for 40 min at 45 °C, thereafter 0.5 ml of 5,Cr-labeled RBC suspension was transfused into a rat via a tail vein.…”

Section: Methodsmentioning

confidence: 99%

Thrombocytopenia in Graves’ Disease: Effect of T<sub>3 </sub>on Platelet Kinetics

Kurata¹,

Nishioeda²,

Tsubakio³

et al. 1980

Acta Haematol

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A study was carried out in which the platelet count was decreased in approximately half the patients with hyperthyroidism and gradually increased with treatment. Platelet disappearance curves were curvilinear and the platelet survival was shortened in the hyperthyroid state. Patients maintained in a euthyroid state for 3 months or less continued to have a shortened platelet survival. The survival returned to normal after 6 months or more of euthyroid status. In order to clarify the cause of the decreased platelet count in the patients, animal experiments were performed. T₃-injected rats had decreased platelet counts and shortened platelet survival. When platelets obtained from T₃-injected rats were transfused to a control group of untreated rats, the platelet survivals were normal. When platelets obtained from the control group of rats were transfused to T₃-injected rats, the platelet survivals were shortened. Disappearance of heat-damaged RBC from the circulation was also accelerated in T₃-injected rats. This suggests that thrombocytopenia in Graves’ disease is caused by an increased sequestration potency of the reticulo-endothelial phagocyte system stimulated by thyroid hormone.

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“…Previous studies have shown that corticosteroids decrease the clearance of antibody-coated red cells in man (3,6) and rats (7) and IgG-and/or C3-coated red cells in guinea pigs (8). In the latter study Atkinson et al demonstrated that IgG-sensitized erythrocytes were cleared in corticosteroid-treated guinea pigs as if they had fewer IgG molecules per red cell, suggesting a decreased recognition of immunoglobulin-or complement-coated cells by the macrophages of the reticuloendothelial system of the steroid-treated animal.…”

mentioning

confidence: 94%

Effect of corticosteroids on the human monocyte IgG and complement receptors.

Schreiber¹,

Parsons²,

McDermott³

et al. 1975

J. Clin. Invest.

178

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A B S T R A C T A quantitative in vitro assay was employed to directly assess the effect of corticosteroids on the IgG and complement receptor function of human mononuclear phagocytic cells. In this system corticosteroids-were solubilized with cholesterol-phospholipid sonicated dispersions before exposure to mononuclear cells. Solubilized corticosteroids at concentrations between 10-' and 10' M inhibited both IgG and complement receptor activity in a dose-response fashion. Inhibition was dependent upon the time of interaction of the mononuclear cells with corticosteroids and was halfmaximal by 15 min. The inhibitory effect at all concentrations of hydrocortisone was partially overcome by increasing the number of IgG molecules per erythrocyte. Hydrocortisone also inhibited the binding of erythrocytes coated with both IgG and C3, despite the fact that when both were on the erythrocyte surface a synergistic effect on binding to mononuclear cells was observed. At the steroid concentrations employed, the capacity of mononuclear cells to exclude trypan blue and to take up latex particles and neutral red was unaffected. Mineralocorticoids also inhibited receptor activity, but the sex hormones were less effective. These studies demonstrate an effect of steroid hormones on cell membrane receptor function, and they suggest that an inhibition of the recognition system for IgG and C3 in vivo may explain, in part, the effect of corticosteroids in man.

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Inhibition of Red Cell Sequestration by Cortisone

Cited by 34 publications

References 49 publications

Effects of Corticosteroids and Splenectomy on the Immune Clearance and Destruction of Erythrocytes

Effects of Corticosteroids and Splenectomy on the Immune Clearance and Destruction of Erythrocytes

Thrombocytopenia in Graves’ Disease: Effect of T<sub>3 </sub>on Platelet Kinetics

Effect of corticosteroids on the human monocyte IgG and complement receptors.

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