Inhibition of <scp>DMBA</scp>‐induced Oral Squamous Cells Carcinoma Growth by Brazilian Red Propolis in Rodent Model

Ribeiro, Danielle Rodrigues; Alves, Ângela Valéria Farias; Santos, Esaú Pinheiro Dos; Padilha, Francine Ferreira; Gomes, Margarete Zanardo; Rabelo, Alessandra Silva; Cardoso, Juliana Cordeiro; Massarioli, Adna Prado; Alencar, Severino Matias de; Albuquerque‐Júnior, Ricardo Luiz Cavalcanti de

doi:10.1111/bcpt.12374

Cited by 28 publications

(21 citation statements)

References 45 publications

(64 reference statements)

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“…Ribeiro et al . () verified that an oral administration of hydroalcoholic extract of Brazilian red propolis exerted chemopreventive effects on 9,10‐dimethyl‐1,2‐benzanthracene‐induced oral squamous cell carcinomas in rodents.…”

Section: Biological Propertiesmentioning

confidence: 72%

Biological Properties and Therapeutic Applications of Propolis

2016

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Propolis is a resinous material collected by bees from bud and exudates of the plants, mixed with bee enzymes, pollen and wax. In this review, the biological properties of propolis and some therapeutic applications are discussed. The same biological activities have been investigated until today, using samples from different geographic regions. Thus, the study of the biological properties of a given sample should always be associated with its chemical composition and botanical source, representing a particular sample of a given geographic area, exploring its biological potential and the role of its constituents. Efforts have been carried out to explain propolis' mechanisms of action in vivo and in vitro, but the majority of propolis' targets and actions are still unclear. The number of formulations containing propolis and patents have increased, although propolis extracts have been used deliberately with different recommendations, not always mentioning the chemical composition, vegetal source and the methods of extraction. Clinical studies will help to obtain criterious recommendations in view of the expected outcomes. Further investigation should explore the effects of common compounds found in the samples from all over the world in an attempt to standardize the research on propolis and to obtain new drugs. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Biological Propertiesmentioning

confidence: 72%

Biological Properties and Therapeutic Applications of Propolis

2016

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“…Finally, they suggested that HERP exerts chemopreventive activity on the progression of DMBAinduced epithelial dysplasia to OSCC in an experimental model of labial carcinogenesis [23]. The study limitations included difficulty in working with animals when injected propolis and possible death rats during this study.…”

Section: Discussionmentioning

confidence: 96%

An Intervention Airing the Effect of Iranian Propolis on Epithelial Dysplasia of the Tongue: A Preliminary Study

Salehi¹,

Mina

Moghadamnia

et al. 2017

JCDR

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Introduction: Since oral cancer is one of the causes of mortality, the use of materials or methods that can reduce cancer or prevent its progression has particular importance.Aim: Aim of the study was to evaluate the antitumor effects of Iranian propolis on dysplastic changes of oral mucosa in rats. Materials and Methods:This study was performed on 28 Wistar male rats (aged 7-11 weeks, 160±20 g). They were divided into four groups of seven rats. The Group 1 received: 0.5% 7,12-Dimethylbenz[a]anthracene (DMBA), the Group 2: 0.5% DMBA and 100 mg/kg propolis, the Group 3: 0.5% DMBA and 200 mg/ kg propolis, and the Group 4: 0.5% DMBA and 400 mg/kg propolis. DMBA in all groups was administered topically (brush) and propolis was injected intraperitoneally. DMBA was brushed twice on the lingual dorsum three times a week for 20 weeks. Propolis injection just every other day and in the days after DMBA was administered for 20 weeks. Rats were sacrificed, and histological examinations were performed on tongue specimen.Results: Propolis can reduce the degree of dysplasia in doses 100 mg/kg, 200 mg/kg, and 400 mg/kg compared to control (Group 1) (p=0.017, p=0.02, and p=0.002, respectively). Conclusion:The results of this study showed propolis can dose-dependently prevent DMBA-induced dysplasia of the oral mucosa in animal model.

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“…(Fabaceae, [ 10 ]) shows various pharmacological properties of clinical interest, also being considered a functional food [ 11 , 12 , 13 ]. In particular, and due to its significant antioxidant activity [ 14 , 15 , 16 ], Brazilian red propolis has been proposed for dermal healing [ 17 , 18 ], and for the treatment of cancer cells [ 14 , 15 , 19 , 20 ], as an antimicrobial [ 16 ], antiproliferative [ 21 , 22 ], antihypertensive [ 23 ], and as a neuroprotective [ 11 ]. Several compounds have been identified in this resin, including the isoflavonoids formononetin, biochanin A, medicarpin, and pinocembrin [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Red Propolis and Its Dyslipidemic Regulator Formononetin: Evaluation of Antioxidant Activity and Gastroprotective Effects in Rat Model of Gastric Ulcer

et al. 2020

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Propolis has various pharmacological properties of clinical interest, and is also considered a functional food. In particular, hydroalcoholic extracts of red propolis (HERP), together with its isoflavonoid formononetin, have recognized antioxidant and anti-inflammatory properties, with known added value against dyslipidemia. In this study, we report the gastroprotective effects of HERP (50–500 mg/kg, p.o.) and formononetin (10 mg/kg, p.o.) in ethanol and non-steroidal anti-inflammatory drug-induced models of rat ulcer. The volume, pH, and total acidity were the evaluated gastric secretion parameters using the pylorus ligature model, together with the assessment of gastric mucus contents. The anti-Helicobacter pylori activities of HERP were evaluated using the agar-well diffusion method. In our experiments, HERP (250 and 500 mg/kg) and formononetin (10 mg/kg) reduced (p < 0.001) total lesion areas in the ethanol-induced rat ulcer model, and reduced (p < 0.05) ulcer indices in the indomethacin-induced rat ulcer model. Administration of HERP and formononetin to pylorus ligature models significantly decreased (p < 0.01) gastric secretion volumes and increased (p < 0.05) mucus production. We have also shown the antioxidant and anti-Helicobacter pylori activities of HERP. The obtained results indicate that HERP and formononetin are gastroprotective in acute ulcer models, suggesting a prominent role of formononetin in the effects of HERP.

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Inhibition of DMBA‐induced Oral Squamous Cells Carcinoma Growth by Brazilian Red Propolis in Rodent Model

Cited by 28 publications

References 45 publications

Biological Properties and Therapeutic Applications of Propolis

Biological Properties and Therapeutic Applications of Propolis

An Intervention Airing the Effect of Iranian Propolis on Epithelial Dysplasia of the Tongue: A Preliminary Study

Red Propolis and Its Dyslipidemic Regulator Formononetin: Evaluation of Antioxidant Activity and Gastroprotective Effects in Rat Model of Gastric Ulcer

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