Inhibition of Several Antibiotics on D-Amino Acid Oxidase

Nakamura, Tõru

doi:10.5925/jnsv1954.5.277

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…of D-amino acid oxidase from hog kidney and determinations of FAD by means of spectrophotometry were performed as described in the previous paper (6). Thiamine and TDP employed as inhibitors were supplied from Lederle (Japan), Ltd..…”

Section: Preparationsmentioning

confidence: 99%

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Inhibition of D-Amino Acid Oxidase by Thiamine and Thiamine Diphosphate

Nakamura

1960

J. Vitaminol

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Section: Preparationsmentioning

confidence: 99%

“…For measurement of enzymatic activity the rate of O2-uptake was detev mined by the usual Warburg technique as described in the previous paper (6).…”

Section: Preparationsmentioning

confidence: 99%

Inhibition of D-Amino Acid Oxidase by Thiamine and Thiamine Diphosphate

Nakamura

1960

J. Vitaminol

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Genomic and metabolomic profiling reveal Streptomyces rochei S32 contributes to plant growth by nitrogen fixation and production of bioactive substances

Wei,

Jiao,

Nie

et al. 2024

Plant Soil

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The use of plant growth-promoting rhizobacteria in crop production necessitates an understanding of the underlying mechanisms. We investigated the potential mechanisms of plant growth promotion by Streptomyces rochei S32 in wheat and tomato crops. MethodsThe effects of S. rochei S32 on plant growth and its antagonistic activity against soil-borne pathogenic fungi were tested in petri dishes. The underlying molecular mechanisms were identi ed based on wholegenome sequencing and bioinformatics analysis. The results of genomic analysis were veri ed by widely targeted metabolomics and mechanism studies of plant growth promotion. ResultsThe growth of crop seedlings treated with the cell-free fermentation broth of S. rochei S32 was markedly improved in 15 d. This effect was demonstrated by increased plant height (24.7%) and root length (17.4%) of wheat (400-fold dilution), as well as extended root length (40.9%) of tomato (200-fold dilution). S. rochei S32 showed antagonistic activity against multiple pathogenic fungi, especially Macropoma kawatsukai. The bacterial genome contains an 8,041,158-bp chromosome and two plasmids. A total of 7486 annotated genes were classi ed into 31 Gene Ontology functional categories. Genomic analysis revealed the potential for the production of indole-3-acetic acid, fungal cell wall hydrolases, antibiotics (e.g., candicidin, streptothricin, borrellin, alba avenone), and siderophores. Thirtynine phytohormones and 2205 secondary metabolites were detected, including indole-3-acetic acid, phytosphingosine, haloprogin, acivicin, and corynebactin. Normal bacterial growth occurred on a nitrogen-free medium. ConclusionS. rochei S32 can promote plant growth directly or indirectly through nitrogen xation and production of phytohormones, extracellular hydrolases, antibiotics, and siderophores.

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Genomic and metabolomic insights into potential mechanisms of plant growth promotion by Streptomyces rochei S32 in various crops

Wei,

Jiao,

Nie

et al. 2023

Preprint

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Aims The use of plant growth-promoting rhizobacteria in crop production necessitates an understanding of the underlying mechanisms. We investigated the potential mechanisms of plant growth promotion by Streptomyces rochei S32 in wheat and tomato crops. Methods The effects of S. rochei S32 on plant growth and its antagonistic activity against soil-borne pathogenic fungi were tested in petri dishes. The underlying molecular mechanisms were identified based on whole-genome sequencing and bioinformatics analysis. The results of genomic analysis were verified by widely targeted metabolomics and mechanism studies of plant growth promotion. Results The growth of crop seedlings treated with the cell-free fermentation broth of S. rochei S32 was markedly improved in 15 d. This effect was demonstrated by increased plant height (24.7%) and root length (17.4%) of wheat (400-fold dilution), as well as extended root length (40.9%) of tomato (200-fold dilution). S. rochei S32 showed antagonistic activity against multiple pathogenic fungi, especially Macropoma kawatsukai. The bacterial genome contains an 8,041,158-bp chromosome and two plasmids. A total of 7486 annotated genes were classified into 31 Gene Ontology functional categories. Genomic analysis revealed the potential for the production of indole-3-acetic acid, fungal cell wall hydrolases, antibiotics (e.g., candicidin, streptothricin, borrellin, albaflavenone), and siderophores. Thirty-nine phytohormones and 2205 secondary metabolites were detected, including indole-3-acetic acid, phytosphingosine, haloprogin, acivicin, and corynebactin. Normal bacterial growth occurred on a nitrogen-free medium. Conclusion S. rochei S32 can promote plant growth directly or indirectly through nitrogen fixation and production of phytohormones, extracellular hydrolases, antibiotics, and siderophores.

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Inhibition of Several Antibiotics on D-Amino Acid Oxidase

Cited by 3 publications

References 7 publications

Inhibition of D-Amino Acid Oxidase by Thiamine and Thiamine Diphosphate

Inhibition of D-Amino Acid Oxidase by Thiamine and Thiamine Diphosphate

Genomic and metabolomic profiling reveal Streptomyces rochei S32 contributes to plant growth by nitrogen fixation and production of bioactive substances

Genomic and metabolomic insights into potential mechanisms of plant growth promotion by Streptomyces rochei S32 in various crops

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