Inhibition of Sperm Binding and Fertilization of Human Ova by Antibody to Porcine Zona Pellucida and Human Sera

Zona pellucida antibodies in human sera

“…Their work indicated a low to moderate level of porcine-human zona antigenic similarity. The inhibition of in-vitro human sperm binding to human oocytes by antiporcine zona/ovary sera, described by Inoue, Fujii & Kami (1979) and Trounson, Shivers, McMaster & Lopata (1980) provided further evidence. However, the precise nature or degree of the similarity is still in question because of the heterogeneity of the antisera used and the lack of knowledge of the molecular composition of the zonae in the two species.…”

Long-term effects of porcine zonae pellucidae immunocontraception on ovarian function in feral horses (Equus caballus)

“…Sacco (1977), Hasegawa et al (1985) and Trounson et al (1980) have demon¬ strated that human and porcine zonae share common antigens. In several of these studies, the administration of PZP or purified ZP3 was accompanied by disruption of ovarian function and cyclic endocrine patterns, but, in most cases, normal ovarian function returned over an interval ranging from several cycles to 300 days.…”

Solid-Phase Antigen Immunoassay for the Detection of Anti-Zona Pellucida-Antibodies in Clinically Defined Sera

“…tö compare results from different laboratones. This Trounson et al (7) have shown that the m vitro would ^ an additional diagnostic aid for immu nologfertilizatmn of human pocytes can-be completely ^^ infertm Jn ^ ^^ work & defined blocked by antiporane-zona pellucida-antibodies. n aration (14) was used which was ob _ Furthermore it was reported that the sera of mferti e solubilization of porcine zona pellucida women contam auto-antibodies agamst the zona pel-^ '^^ 3 S5/ .…”