Inhibition of starch digestion by the green tea polyphenol, (−)‐epigallocatechin‐3‐gallate

Forester, Sarah C.; Gu, Yeyi; Lambert, Joshua D.

doi:10.1002/mnfr.201200206

Cited by 128 publications

(122 citation statements)

References 39 publications

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“…Although there have been few studies on the effects of dietary supplementation with propolis on enzyme activity, decreased amylase activity may be related to the complex composition of polyphenols in propolis. Several authors have reported that amylase activity may be reduced by anthocyanins, phenolic acids and flavonoids in the diet (McDougall et al 2005;Tadera et al 2006;Forester et al 2012). In fact, Matsui et al (2004) also showed an inhibitory effect of propolis on amylase activity and as suggested by Hashim et al (2013), the nature of amylase inhibition by polyphenols is non-competitive.…”

Section: Resultsmentioning

confidence: 97%

Intestinal morphology and activity of digestive enzymes in broilers fed crude propolis

et al. 2014

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. 2014. Intestinal morphology and activity of digestive enzymes in broilers fed crude propolis. Can. J. Anim. Sci. 94: 105Á114. Propolis is a resin produced by bees that has been investigated for its potential to increase the performance of broiler chickens. Therefore, this study aimed to evaluate the inclusion of crude propolis in the diets of broiler chickens from 1 to 21 d of age. A total of 1020 male chicks were distributed in a completely randomized experimental design into six treatments (0, 100, 200, 300, 400 and 500 ppm of crude propolis), with five replications, and 34 birds per experimental unit. The experimental diets were provided from 1 to 21 d of age and subsequently (from 22 to 42 d of age) the birds were fed a nutritionally complete ration based on corn and soybean meal. All supplemented groups showed similar growth performance in all growth phases (P!0.05); however, there was a linear increase in carcass yield at 42 d of age according to increase in crude propolis inclusion from 1 to 21 d of age (PB0.05). At 7 d of age, relative weight of the gizzard increased linearly (PB0.05) with increasing propolis, and at 21 d of age, relative weight of the large intestine showed a quadratic (P B0.05) response, with the lowest value predicted to occur at 278 ppm of crude propolis. The ileum crypt depth at 21 d of age was affected by propolis, with a quadratic response (P B0.05) and highest value estimated at 323 ppm. At 21 d of age, sucrase activity in the jejunum increased linearly with increasing propolis and maltase activity in the ileum showed a quadratic (PB0.05) response, which predicted highest activity at 292 ppm. Amylase activity was lower in animals supplemented with 100 and 400 ppm of propolis at 21 d of age (PB0.05) compared with the control group. Thus, the crude propolis supplementation is not recommended in broiler diets from 1 to 21 d old given that it does not influence the performance, despite small changes in intestinal morphophysiology at 21 d of age.

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Section: Resultsmentioning

confidence: 97%

Intestinal morphology and activity of digestive enzymes in broilers fed crude propolis

et al. 2014

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“…This result was comparable to the inclusion of crude propolis , which showed that pancreatic amylase activity decreased with dietary inclusion of crude propolis, possibly related to the inhibitory effect of propolis polyphenols on amylase and maltase activity (MATSUI et al, 2004;ZHANG et al, 2015), despite the low concentration of these compounds in the residue. Many authors have shown that amylase and maltase activity may be decreased by anthocyanins, phenolic acids, and flavonoids (FORESTER et al, 2012;HANHINEVA et al, 2010;MCDOUGALL et al, 2005). This is due to either non-competitive inhibition associated with the number of hydroxyl groups on the B-ring of the flavonoid skeleton, and consequent formation of hydrogen bonds between the hydroxyl groups of the polyphenol ligands and catalytic site of the enzyme (LO PIPARO et al, 2008), or the antioxidant properties of the polyphenols, which may also inhibit amylase activity (HASHIM et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Propolis residue inclusion in the diet affects digestive enzyme activity in broiler chickens

Duarte

Eyng

Murakami

et al. 2017

SCA

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This study investigated the effects of the inclusion of solid propolis residue (PR) from alcoholic propolis extraction in the diets of broiler chickens from 1 to 21-d of age on their performance, intestinal morphology, and digestive enzyme activity. 405 male chicks were distributed in a completely randomized design with five treatments (inclusion of 0, 1, 2, 3 and 4% PR in the diets), and three replications with 27 birds each. The birds were fed experimental diets from 1 to 21-d of age and basal diet from 22 to 42-d of age. Feed intake (from 1 to 21-d and 1 to 42-d of age) decreased linearly with increasing levels of PR inclusion (P < 0.05). Dietary inclusion of PR did not affect intestinal morphology at 7 and 21-d of age (P > 0.05). Pancreatic amylase activity presented a quadratic response at 7 and 21-d of age, with its lowest activity estimated at 2.45 and 1.91% PR inclusion, respectively. At 7-d of age, trypsin activity decreased linearly, whereas chymotrypsin activity varied quadratically, with its activity estimated at 2.06% PR inclusion. Intestinal maltase activity varied quadratically with lowest activity predicted at 1.57% PR inclusion at 21-d of age. The dietary inclusion of solid propolis residue of propolis decreases feed intake in broilers and modulates their intestinal and pancreatic enzyme activity. Key words: Disaccharidases. Intestinal morphometry. Pancreatic enzyme. Propolis byproduct. ResumoEste estudo investigou os efeitos da inclusão do resíduo sólido da extração alcoólica da própolis (PR) em dietas de frangos de corte de 1 a 21 dias de idade no desempenho, morfologia intestinal e atividade de enzimas digestivas. 405 frangos machos foram distribuídos em um delineamento inteiramente casualizado com cinco tratamentos (inclusão de 0, 1, 2, 3 e 4% de PR na ração), e três repetições com 27 aves cada. As aves receberam as dietas experimentais de 1 a 21 dias de idade e dieta basal de 22 a 42 dias de idade. O consumo de ração (1 a 21 dias e 1 a 42 dias) diminuiu linearmente com o aumento de inclusão de PR (P < 0,05). A inclusão de PR não afetou a morfometria intestinal aos 7 e 21 dias de idade (P > 0.05). A atividade da amilase pancreática apresentou resposta quadrática aos 7 e 21 dias de idade (P < 0,05), com menores atividades estimadas ao nível de 2,45 e 1,91% de inclusão de PR, respectivamente. Aos 7 dias de idade, a atividade da tripsina diminuiu linearmente, enquanto

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“…Matsui et al (2004) reported that the bioactive constituents of propolis can inhibit α-glucosidase activity [38]. Similarly, epigallocatechin gallate (EGCG), the primary flavonol in green tea, has been shown to inhibit -amylase activity [39] and both grape seed and tea extracts were potent inhibitors of both -amylase and -glucosidase activity in healthy volunteers [40]. In a meta-analysis of 17 randomized controlled trials it has been reported that the beneficial effect of natural antioxidants upon glycemia may be more pronounced in subjects that are at higher risk for metabolic syndrome [41].…”

Section: Discussionmentioning

confidence: 99%

The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts

Chepulis¹,

Al-Aubaidy²,

Page³

2016

FFHD

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Background: Obesity and diabetes are highly prevalent in Western countries. Both of these conditions can be associated with impaired glucose control and hyperglycemia. Studies have identified that antioxidants have the ability to regulate blood glucose levels. However, the effects of specific high-antioxidant food extracts on blood glucose levels have not been well characterized. Thus, this study aimed to measure the effects of selected antioxidant food extracts on postprandial glucose responses in healthy individuals. Methods:Ten healthy individuals were recruited into a randomized, single-blinded study. Participants consumed five different high-antioxidant food extracts (one per session, each >48 hours apart) that were matched for total antioxidant content 10 mins prior to ingestion of 50 g of available carbohydrate from either a glucose load or white bread (with ham) after an overnight fast. Blood glucose levels were measured using capillary sampling every 15 mins for two hours and the incremental area under the glucose curve (IAUC) was also measured. The IAUC values for the test foods were compared to the glucose-only and bread-only controls.Results: Amla berry-, grape seed-rooibos tea-and green tea-extracts as well as propolis tincture were all strong glycemic modulators, significantly decreasing the IAUC by 25-40% compared to the glucose-only or white bread controls (all p < 0.05). Conclusion:Antioxidants are able to modulate postprandial glucose responses in healthy subjects. These results suggest that further research is warranted to determine whether these antioxidant-rich foods are beneficial to people with prediabetes or type 2 diabetes mellitus.

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Inhibition of starch digestion by the green tea polyphenol, (−)‐epigallocatechin‐3‐gallate

Cited by 128 publications

References 39 publications

Intestinal morphology and activity of digestive enzymes in broilers fed crude propolis

Intestinal morphology and activity of digestive enzymes in broilers fed crude propolis

Propolis residue inclusion in the diet affects digestive enzyme activity in broiler chickens

The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts

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