Inhibition of synaptosomal enzymes by local anesthetics

Sidek, Hasidah Mohd; Nyquist-Battie, Cynthia; Vanderkooi, Garret

doi:10.1016/0304-4165(84)90208-3

Cited by 38 publications

(15 citation statements)

References 19 publications

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“…We found that aromatic hydrocarbons and chlorinated aliphatic hydrocarbons inhibit ATPase activities in human erythrocyte ghost membrane dosedependently. In addition other membrane-active compounds such as free fatty acids (15) and local anesthetics (13) have been shown to cause an inhibiting effect on ATPase in synaptosomal membranes. Of the alcohols tested in the present study, ethanol, propanol, and butanol showed slight dose-dependent ATPase activation.…”

Section: Discussionmentioning

confidence: 99%

Effects of industrial organic solvents on human erythrocyte membrane adenosine triphosphatase activities in vitro.

Korpela¹,

Tähti²

1987

Scand J Work Environ Health

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CorrectionsSee 1988;14(1):0 for a correction.Key terms: adeno sine triphosphatase; alcohols; aliphatic chlorinated hydrocarbon; amendment and correction; aromatic hydrocarbon; erythrocyte membrane adeno sine triphosphatase; human erythrocyte membrane; human erythrocyte membrane adeno sine triphosphatase; human erythrocyte membrane adeno sine triphosphatase activity; in vitro; industrial organic solvent; membrane effect; organic solvent This article in PubMed: www.ncbi.nlm.nih.gov/pubmed/2963375

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Section: Discussionmentioning

confidence: 99%

Effects of industrial organic solvents on human erythrocyte membrane adenosine triphosphatase activities in vitro.

Korpela¹,

Tähti²

1987

Scand J Work Environ Health

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“…Some anesthetics have been reported to inhibit Ca +2 -ATP as and Na + /Ca +2 exchanger of the synaptosomal plasma membrane [25]. The an other study, anesthetics inhibited Na + ,K + -ATPase, Mg +2 -ATPase and acetylcholinesterase activity from rat cerebral cortex [25].…”

Section: Discussionmentioning

confidence: 99%

“…Several study reports concerning strong inhibitory effects of antibiotic and anesthetics on erythrocytes G6PD enzyme have been published [21,22]. Some anesthetics have been reported to inhibit Ca +2 -ATP as and Na + /Ca +2 exchanger of the synaptosomal plasma membrane [25]. The an other study, anesthetics inhibited Na + ,K + -ATPase, Mg +2 -ATPase and acetylcholinesterase activity from rat cerebral cortex [25].…”

Section: Discussionmentioning

confidence: 99%

Effects of some drugs on human erythrocyte glucose 6-phosphate dehydrogenase: anin vitrostudy

Akkemik

Budak

Çiftçi

2010

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Local anaesthetics are known to exert inhibitory effects on ion movements across the membrane. For example, local anaesthetics inhibit Na channels (Lee, 1976;Heidmann & Changeux, 1979), Ca channels (Spedding & Berg, 1985), K channels (Ohya et al, 1987), Na, K-ATPase (Sidek et al, 1984), Ca, Mg-ATPase (Garcia- Martin & Gutierrez-Merino, 1986) and Na/Ca exchange (Michaelis & Michaelis, 1983). It is possible that change in the K+-induced contraction after muscarinic stimulation was inhibited by these inhibitory effects of local anaesthetics on transmembrane ion movements.…”

Section: Discussionmentioning

confidence: 99%

Blockade by the local anaesthetic, tetracaine, of desensitization of Ca‐induced Ca release after muscarinic stimulation in smooth muscle

Hishinuma

Uchida

1991

British J Pharmacology

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1 Desensitization of contractile responses dependent on release of intracellularly stored Ca elicited by carbachol, histamine or caffeine was measured after desensitizing treatment with carbachol or histamine in the presence or absence of local anaesthetics in Ca-free solution containing 2mm EGTA in the smooth muscle of guinea-pig taenia caecum. 2 Histamine-induced homologous desensitization was inhibited by tetracaine and procainamide. Dibucaine did not exert an inhibitory effect on the desensitization. This is consistent with our previous findings concerning the effects of local anaesthetics on the densitization of histamine H -receptors measured under normal physiological conditions. 3 Carbachol induced a functional change of intracellular Ca stores which resulted in heterologous desensitization. Tetracaine completely blocked carbachol-induced desensitization of the caffeine-elicited contraction, but in the case of carbachol-induced desensitization of carbachol-and histamine-elicited contractions, this blocking effect of tetracaine was very weak and absent, respectively. The other local anaesthetics used did not affect the desensitization. These results suggest that the Ca-induced and inositol trisphosphate-induced Ca release mechanisms were both desensitized by carbachol and that the desensitization of the Ca-induced Ca release mechanism was selectively blocked by tetracaine.

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Inhibition of synaptosomal enzymes by local anesthetics

Cited by 38 publications

References 19 publications

Effects of industrial organic solvents on human erythrocyte membrane adenosine triphosphatase activities in vitro.

Effects of industrial organic solvents on human erythrocyte membrane adenosine triphosphatase activities in vitro.

Effects of some drugs on human erythrocyte glucose 6-phosphate dehydrogenase: anin vitrostudy

Blockade by the local anaesthetic, tetracaine, of desensitization of Ca‐induced Ca release after muscarinic stimulation in smooth muscle

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