Inhibition of T Cell Responses by Transferrin-Coupled Competitor Peptides

Zaliauskiene, Lolita; Fazio, Rebecca L.; Kang, Seung Kyu; Sparks, Kerri; Weaver, Casey T.; Zinn, Kurt R.; Collawn, James F.

doi:10.1385/ir:26:1-3:077

Cited by 4 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…31 TfR1 recycles over 100 times and undergoes several acylation-deacylation cycles. 32 Because post-transcriptional downregulation of TfR1 in þFAC conditions requires several hours, 33 given that the half-life of TfR1 is greater than 24 hr, 34 post-translational TfR1 regulation by palmitoylation might represent an alternative means of rapidly modulating cellular iron content, a regulatory system that could be impaired in NBIA.…”

Section: Discussionmentioning

confidence: 99%

Impaired Transferrin Receptor Palmitoylation and Recycling in Neurodegeneration with Brain Iron Accumulation

Drecourt

Babdor

Dussiot

et al. 2018

The American Journal of Human Genetics

View full text Add to dashboard Cite

Neurodegeneration with brain iron accumulation (NBIA) is a genetically heterogeneous condition characterized by progressive dystonia with iron accumulation in the basal ganglia. How NBIA-associated mutations trigger iron overload remains poorly understood. After studying fibroblast cell lines from subjects carrying both known and unreported biallelic mutations in CRAT and REPS1, we ascribe iron overload to the abnormal recycling of transferrin receptor (TfR1) and the reduction of TfR1 palmitoylation in NBIA. Moreover, we describe palmitoylation as a hitherto unreported level of post-translational TfR1 regulation. A widely used antimalarial agent, artesunate, rescued abnormal TfR1 palmitoylation in cultured fibroblasts of NBIA subjects. These observations suggest therapeutic strategies aimed at targeting impaired TfR1 recycling and palmitoylation in NBIA.

show abstract

Section: Discussionmentioning

confidence: 99%

Impaired Transferrin Receptor Palmitoylation and Recycling in Neurodegeneration with Brain Iron Accumulation

Drecourt

Babdor

Dussiot

et al. 2018

The American Journal of Human Genetics

View full text Add to dashboard Cite

show abstract

“…Integrative sampling system can also be applied for further monitoring of exposure, fate and concentrations of toxic compound� discharged from waste water treatment plant to the receiving waters [9].…”

Section: <I) ''<mentioning

confidence: 99%

Methods of monitoring of waste water treatment efficiency

Augulyte

Bergqvist²,

Zaliauskiene³

2019

Eco-Tech

View full text Add to dashboard Cite

One major result of implementing the Water Frame Directive (WFD) for the water industry is the likelihood of more stringent requirements for the efficiency of removal of the pollutants included in the list of WFD priority substances. During the last decade, an ongoing debate on the technical aspects of water treatment and on the fate and effects of its constituents after discharge are taking place. Due to the recent development of analytical techniques, the knowledge about the chemistry and toxicology of the waste water has increased considerable. Characterization of the oil treatment efficiency by total petroleum hydrocarbon concentration (TPH) is not sufficient any more. Waste water before and after treatment should be characterized by toxicity and amounts of the individual compounds and mixtures which trigger the toxicity.In the situations where more efficient oil removal from waste water is required to meet the requirements, there are a number of treatment options available, including some tertiary ("polishing") treatment systems. New generation tertiary wastewater treatment system for removal or reducing of the oil compounds, including dissolved polycyclic aromatic hydrocarbons, bearing along most toxic potential, was developed under a Eureka funded project. The new waste water treatment system involves novel monitoring device to verify that the dissolved and bioavailable fraction of the contaminants are degraded, and that the final effluent is cleaner also from a toxicity point of view. Previous studies showed that more toxic compounds might be produced during the treatment process due to the transformation of the original chemicals.The monitoring device consists of a membrane-based diffusive, time integrative (2-30 days) sampler. The newly developed fast analytical method for the analysis of membrane extracts enable to give us information on the dissolved concentrations for more than 80 oil related compounds in the effluents as well as the toxicity results, by using standard bio-assay tests. Moreover the monitoring system is capable to accurately sample most of the WFD priority substances in waste water treatment effluent waters. lt was found that some of the compounds were effectively removed in waste water treatment plant (WWTP), but other compounds remained in the dissolved phase at the same concentrations.Furthermore, volatilization of low molecular weight PAHs during the treatment process was studied by means of the new monitoring system, resulting in the identification of significant release of WFD pollutants to the air. The changes in time-integrative toxicity during the 183 https://doi.org/10.15626/Eco-Tech.2005.019Kalmar ECO-TECH '05 and The Second Baltic Symposium on Environmental Chemistry KALMAR, SWEDEN. November 28-30, 2005 treatment process were evaluated by standard ecotoxicity analysis using the same membrane extracts. The three bio-assays used were Daphnia magna, Microtox and Algal but also other organism-or cell test systems will be tested further.Our developed monitoring device is the...

show abstract

“…Furthermore, small peptides that can interfere with cytokines or specific cell surface molecules have been developed, and can lead to the inhibition of autoimmune inflammatory reactions (80). Similarly, attempts have been made to block helper T cell responses by the use of competitor peptides whose in vivo efficacy had been increased by coupling to transferrin (81).…”

Section: Cd4+cd25+ Regulatory T Cells (Treg)-cd4+cd25+mentioning

confidence: 99%

Antigen-Specific Tolerogenic and Immunomodulatory Strategies for the Treatment of Autoimmune Arthritis

Satpute

Durai

Moudgil

2008

Seminars in Arthritis and Rheumatism

View full text Add to dashboard Cite

Objectives-To review various antigen-specific tolerogenic and immunomodulatory approaches for arthritis in animal models and patients in regard to their efficacy, mechanisms of action and limitations.Methods-We reviewed the published literature in Medline (PubMed) on the induction of antigenspecific tolerance and its effect on autoimmune arthritis, as well as the recent work on B cell-mediated tolerance from our laboratory. The prominent key words used in different combinations included arthritis, autoimmunity, immunotherapy, innate immunity, tolerance, treatment, and rheumatoid arthritis (RA). Although this search spanned the years 1975 to 2007, the majority of the short-listed articles belonged to the period 1990 to 2007. The relevant primary as well as cross-referenced articles were then collected from links within PubMed and reviewed.Results-Antigen-specific tolerance has been successful in the prevention and/or treatment of arthritis in animal models. The administration of soluble native antigen or an altered peptide ligand intravenously, orally, or nasally, and the delivery of the DNA encoding a particular antigen by gene therapy have been the mainstay of immunomodulation. Recently, the methods for in vitro-expansion of CD4+CD25+ regulatory T cells have been optimized. Furthermore, interleukin-17 has emerged as a promising new therapeutic target in arthritis. However, in RA patients, non-antigen-specific therapeutic approaches have been much more successful than antigen-specific tolerogenic regimens.Conclusion-An antigen-specific treatment against autoimmune arthritis is still elusive. However, insights into newly emerging mechanisms of disease pathogenesis provide hope for the development of effective and safe immunotherapeutic strategies in the near future.

show abstract

Inhibition of T Cell Responses by Transferrin-Coupled Competitor Peptides

Cited by 4 publications

References 21 publications

Impaired Transferrin Receptor Palmitoylation and Recycling in Neurodegeneration with Brain Iron Accumulation

Impaired Transferrin Receptor Palmitoylation and Recycling in Neurodegeneration with Brain Iron Accumulation

Methods of monitoring of waste water treatment efficiency

Antigen-Specific Tolerogenic and Immunomodulatory Strategies for the Treatment of Autoimmune Arthritis

Contact Info

Product

Resources

About