Inhibition of T3-receptor binding by Nitrofen

Brandsma, Annelies E.; Tibboel, Dick; Vulto, Irma; Vijlder, J. J. M. De; Have-Opbroek, A. A. W. Ten; Wiersinga, Wilmar M.

doi:10.1016/0304-4165(94)90050-7

Cited by 34 publications

(32 citation statements)

References 18 publications

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“…These results are supported by a series of experiments undertaken in the nitrofen rat model for CDH. This study was inspired by the promising results obtained by the administration of glucocorticoids, thyroid hormone or vitamin A to nitrofen-treated rats (13,16,17,(25)(26)(27). In our previous study, we have shown the expression of the nuclear hormone receptors in human lung from 13.5 wk until term with no change in localization throughout development (21).…”

Section: Discussionmentioning

confidence: 99%

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Spatial and Temporal Expression of Glucocorticoid, Retinoid, and Thyroid Hormone Receptors Is Not Altered in Lungs of Congenital Diaphragmatic Hernia

et al. 2006

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ABSTRACT:The degree of associated pulmonary hypoplasia and persistent pulmonary hypertension are major determination factors for survival in congenital diaphragmatic hernia (CDH) patients. Glucocorticoids, thyroid hormone, and vitamin A have been shown to be involved in human lung development. To determine their therapeutic potential in hypoplastic lungs of CDH patients, the temporal and spatial expression of glucocorticoid receptor, thyroid hormone receptors, retinoic acid receptors, and retinoid X receptors were evaluated in lungs of CDH patients, hypoplastic lungs from other causes, and normal lungs. As a series of supportive experiments, the expressions of these receptors were analyzed in lungs of nitrofen-induced CDH rats. Immunohistochemistry (human and rat) and in situ hybridization (rat) demonstrated no overt difference between CDH, hypoplastic, and control lungs, either in the localization nor the timing of the first expression of all analyzed receptors. The mRNA expression of each receptor was detected in all human CDH lungs by quantitative PCR. Our results suggest that, as far as receptors are concerned, hypoplastic lungs of fetuses and newborns with CDH are potentially as responsive to glucocorticoids, thyroid hormone, and retinoic acid as the lungs of normal children.

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Section: Discussionmentioning

confidence: 99%

“…Secondly, nitrofen-treated dams have less malformed fetuses if T 4 is given during pregnancy; and, thirdly, nitrofen-treated pregnant rats have lowered T 4 and TSH levels (12). In addition, our group has demonstrated that nitrofen decreases the binding of T 3 to the thyroid hormone receptor ␣1 and ␤1 in a noncompetitive way (13).…”

mentioning

confidence: 81%

Spatial and Temporal Expression of Glucocorticoid, Retinoid, and Thyroid Hormone Receptors Is Not Altered in Lungs of Congenital Diaphragmatic Hernia

et al. 2006

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“…84 Lung hypoplasia might represent a secondary sign for thyroid function disturbance during fetal development in utero. 84,85 Estrogenicity PBDEs are also estrogen disruptors. In human T47D breast cancer cells stably transfected with an estrogen responsive luciferase reporter gene construct (pEREtata-Luc), 11 PBDEs showed estrogenic potencies.…”

Section: Thyrotoxicitymentioning

confidence: 99%

“…Nitrofen non-competitively inhibits the binding of T 3 to the alpha-1 and beta-1 form of the thyroid hormone receptor in vitro. 84 Lung hypoplasia might represent a secondary sign for thyroid function disturbance during fetal development in utero. 84,85 Estrogenicity PBDEs are also estrogen disruptors.…”

Section: Thyrotoxicitymentioning

confidence: 99%

Polybrominated Diphenyl Ethers (PBDEs): New Pollutants-Old Diseases

Siddiqi

Laessig²,

Reed³

2003

Clinical Medicine & Research

289

145

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Polybrominated diphenyl ethers (PBDEs) are a class of recalcitrant and bioaccumulative halogenated compounds that have emerged as a major environmental pollutant. PBDEs are used as a flame-retardant and are found in consumer goods such as electrical equipment, construction materials, coatings, textiles and polyurethane foam (furniture padding). Similar in structure to polychlorinated biphenyls (PCBs), PBDEs resist degradation in the environment. Less brominated PBDEs like tetra-, penta-and hexa-demonstrate high affinity for lipids and can accumulate in the bodies of animals and humans. Breast milk from North American women contained much higher amounts of PBDEs than levels in breast milk from Swedish women, indicating that North American exposures to PBDEs may be particularly high. Evidence to date suggests that tetra-and penta-BDEs are likely to be the more toxic and bioaccumulative of the PBDE compounds, compared to octa-and deca-congeners. PBDEs are sold as mixtures, under names such as "pentabromodiphenyl ether" and "octabromodiphenyl ether." The pentabromo product is a mixture of tetra-BDEs and penta-BDEs in approximately equal amounts. Pentabromo consists of PBDEs that are believed to be the most toxic.

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“…However, nitrofen has teratogenic effects and produces several types of anomalies simultaneously besides diaphragmatic hernia, and acts through modifications of the thyroid hormone status in both dam and fetus [4,33]. These findings indicate that application of nitrofen is not a suitable method to demonstrate lung-kidney interrelation in fetal rats.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Hypoplasia Induced by Liquid Paraffin Injection into Fetal Thoracic Cavity with Special Reference to Renal Development in Rats

Morikawa

Katsumoto

Okada

et al. 2000

The Journal of Veterinary Medical Science

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ABSTRACT. The present study was designed to clarify lung-kidney interrelation in fetal rats. On fetal day 20, liquid paraffin (LP) was injected into fetal thoracic cavity to produce pulmonary hypoplasia. No significant difference in body and renal weights were noted between the LP injected and control fetuses. The weight of lung, however, was significantly lower in the LP injected fetuses than in the control ones. Histological examinations on the lung and kidney of the LP injected fetuses revealed that the lung was hypoplastic characterized by rich interstitium and reduced air spaces. In the kidney, mature types of glomeruli and profiles of proximal tubules near them were increased in number. Furthermore, strong expression of EGF immunoreactivity was noted in the apical cytoplasm of epithelium of the proximal tubules in the LP injected fetuses. These findings indicate that lung-kidney interrelation exists in fetal rats during late gestational days, and suggest that interruption of the lung development induces accelerated growth of the kidney in fetal rats.-KEY WORDS: fetal rat, injection, kidney, liquid paraffin, lung.

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Inhibition of T3-receptor binding by Nitrofen

Cited by 34 publications

References 18 publications

Spatial and Temporal Expression of Glucocorticoid, Retinoid, and Thyroid Hormone Receptors Is Not Altered in Lungs of Congenital Diaphragmatic Hernia

Spatial and Temporal Expression of Glucocorticoid, Retinoid, and Thyroid Hormone Receptors Is Not Altered in Lungs of Congenital Diaphragmatic Hernia

Polybrominated Diphenyl Ethers (PBDEs): New Pollutants-Old Diseases

Pulmonary Hypoplasia Induced by Liquid Paraffin Injection into Fetal Thoracic Cavity with Special Reference to Renal Development in Rats

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