Inhibition of the cataleptic effect of tetrahydrocannabinol by other constituents of Cannabis sativa L.

Abstract

Tetrahydrocannabinol (THC) induced catalepsy in mice, whereas a cannabis oil (6.68% w/w THC), four cannabinoids and a synthetic mixture did not. Cannabinol (CBN) and olivetol inhibited THC-induced catalepsy in the mornings and the evenings, but cannabidiol (CBD) exhibited this effect only in the evenings. A combination of CBN and CBD inhibited THC-induced catalepsy equal to that of CBN alone in the mornings, but this inhibition was greater than that produced by CBN alone in the evenings.

Survey on cannabis use in Parkinson's disease: Subjective improvement of motor symptoms

“…The design of these two studies, however, including the doses used, was very different. Although in regular users the subjective improvement of symptoms seemed to correlate well with concentrations of the major metabolite of δ‐9‐THC found in urine, the actions of other plant cannabinoids have to be considered because they may substantially influence the effect of δ‐9‐THC alone 27, 28. The most likely is cannabidiol, which inhibits uptake and hydrolysis of anandamide and acts as a vanilloid receptor (VR 1 ) agonist 29.…”

Inhibition of A23187–induced release of leukotriene B4 in mouse whole blood Ex vivo and human polymorphonuclear cells in vitro by the cannabinoid analgesic cannabidiol

“…Consequently, various synthetic analogues of A '-THC have been developed (Milne and Johnson, 1981) but these drugs were not completely devoid of central hallucinogenic actions. Qualitative structure-activity comparisons among a range of naturally occurring cannabinoids have indicated that those compounds which possess a free C-5 hydroxyl moiety are devoid of central hallucinogenic activity (Formukong et al, 1988a), but retain potent inflammatory and analgesic actions (Formukong et al, 1988b). Cannabidiol (CBD) was found to be the most potent of the analogues studied and in the PBQ-induced mouse writhing test following oral administration was about 360 times more potent than aspirin.…”

Antidepressant‐like effects of cannabidiol in mice: possible involvement of 5‐HT1Areceptors

“…, 2007). CBD is usually described as a non‐psychoactive compound that inhibits some behavioural effects of Δ 9 ‐THC, such as catalepsy in rats (Formukong et al. , 1988) and psychotomimetic and anxiogenic effects in humans (Zuardi et al.…”