Inhibition of the growth and development of asexual and sexual stages of drug-sensitive and resistant strains of the human malaria parasite Plasmodium falciparum by Neem (Azadirachta indica) fractions

Dhar, Ravi; Zhang, Kunyan; Talwar, G.P.; Garg, Sanjay; Kumar, Nirbhay

doi:10.1016/s0378-8741(98)00012-9

Cited by 69 publications

(49 citation statements)

References 18 publications

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“…By contrast, less effort has been channeled towards examining extracts of plants for their activity against the sexual stages of the parasite. Currently, only three plant species have been directly screened for their malaria transmission blocking capacity: Azadirachta indica (Meliaceae) (Dhar et al, 1998;Jones et al, 1994;Lucantoni et al, 2010;Udeinya et al, 2006Udeinya et al, , 2008Yerbanga et al, 2014), Vernonia amygdalina (Asteraceae) and Guiera senegalensis (Combretaceae) (Yerbanga et al, 2014). A. indica has been comprehensively studied and…”

Section: Introductionmentioning

confidence: 99%

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In vitro inhibition of Plasmodium falciparum early and late stage gametocyte viability by extracts from eight traditionally used South African plant species

Moyo

Botha

Nondaba

et al. 2016

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

“…shown to have good gametocytocidal activity in vitro (Dhar et al, 1998;Jones et al, 1994;Udeinya et al, 2008Udeinya et al, , 2006, in vivo (Lucantoni et al, 2010) and ex vivo (Yerbanga et al, 2014). The active components are a diverse range of limonoid compounds (Jones et al, 1994;Lucantoni et al, 2010;Yerbanga et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

In vitro inhibition of Plasmodium falciparum early and late stage gametocyte viability by extracts from eight traditionally used South African plant species

Moyo

Botha

Nondaba

et al. 2016

Journal of Ethnopharmacology

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“…8,[11][12][13] Various other experimental compounds, including chlorguanide, pyrimethamine, atovaquone, tefenoquine (WR-238605), WR-250547, and others, can prevent malaria transmission by either gametocytocidal or sporontocidal activity. [14][15][16][17][18][19][20][21][22][23] The current status of suspected gametocytocidal and/or sporontocidal compounds is summarized by Butcher. 24 In this study, we assessed the sporontocidal activity of four dihydroacridine-diones (WR-233602, WR-243251, WR-250547, and WR-250548) and three fluoroquinolones (WR-279135, WR-279298, and WR-279288) against naturally circulating isolates of Plasmodium vivax.…”

Section: Introductionmentioning

confidence: 99%

Prevention of sporogony of Plasmodium vivax in Anopheles dirus mosquitoes by transmission-blocking antimalarials.

Coleman¹,

Polsa²,

Eikarat³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

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Abstract. The sporontocidal activity of four dihydroacridine-diones (WR-233602, WR-243251, WR-250547, and WR-250548) and three fluoroquinolones (WR-279135, WR-279298, and WR-279288) was determined against naturally circulating isolates of Plasmodium vivax. Laboratory-reared Anopheles dirus mosquitoes were infected with P. vivax by feeding them on gametocytemic volunteers reporting to local malaria clinics in Kanchanaburi and Tak provinces, Thailand. Four days after the infectious feed, mosquitoes were re-fed on uninfected mice treated 90 minutes previously with a given drug at a dose of 100 mg base drug/kg mouse body weight. Sporontocidal activity was determined by assessing both oocyst and sporozoite development. None of the fluoroquinolones exhibited sporontocidal activity against P. vivax, whereas all 4 dihydroacridine-diones affected sporogonic development to some degree. WR-233602 affected oocyst development, but had no impact on sporozoite production, WR-250548 affected oocyst development and had a limited effect on sporozoite production, and WR-243251 and WR-250547 had a marked impact on all phases of sporogony. These data demonstrate that experimental dihydroacridine-diones are capable of interrupting the sporogonic development of P. vivax. These compounds may be useful in preventing malaria transmission.

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“…A. indica and P. guineense extracts were effective in protecting the crops from the various insect pests, with values comparable to the synthetic insecticide (Cymbush R ) used as a positive control. The presence of components capable of influencing the physiology and behaviour of a wide range of insects, mites and nematodes in A. indica and P. guineense extracts (Dhar et al 1998, Schaaf et al 2000, Ngono Ngane et al 2003) may explain their efficacy in the control of insect pests infesting the vegetables studied. The major biologically active components reported in A. indica and P. guineense include: azadirachtin, triterpenoids, piperolein acids, salanine, nimbidin, guineensine, essential oils, sterols and amides, amongst others (Martins et al 1998, Schaaf et al 2000, Siddiqui et al 2000, Muse et al 2003, Ngono Ngane et al 2003, Gopal et al 2007).…”

Section: Insect Pest Abundance As Affected By Plant Extractsmentioning

confidence: 99%

“…In addition, farmers are poorly equipped to handle them. Extracts of Azadirachta indica (neem) and Piper guineense have components capable of influencing the physiology and behaviour of a wide range of insects, mites and nematodes (Dhar et al 1998, Schaaf et al 2000, Ngono Ngane et al 2003. The bark, leaf and seed oil are particularly useful parts of the neem tree (Han et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Effect of mixed cropping and plant extracts on the growth, yield and pest control of jute (Corchorus olitorius L.)

Okunlola¹,

Ofuya

2013

Folia Horticulturae

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This study investigated the effect of plant extracts (Azadirachta indica and Piper guineense) on the growth and yield of jute (Corchorus olitorius L.) (Cor) under sole and mixed cropping with Amaranthus hybridus (Ama) and Celosia argentea (Cel). The highest percentage increase in plant height, number of leaves, number of branches and stem girth (130.6, 865.0, 220.4 and 114.0%, respectively) was found in untreated Cor + Cel, cypermethrin treated Cor + Ama, cypermethrin treated Cor and A. indica extract treated Cor + Ama, respectively. The highest percentage increase in shoot weight (71.0%), marketable yield (53.9%) and total biomass (51.5%) was in A. indica treated C. olitorius. Extract treatment had no effect on the number of branches at four, five and seven weeks after planting (WAP) in Cor + Ama + Cel; four, five and six WAP in Cor + Cel; four and six WAP in Cor + Ama; as well as four and five WAP in Cor. The highest percentage increase in leaf fresh weight was obtained in cypermethrin treated Cor (53.3%) and Cor + Ama + Cel (52.2%), while the smallest increase was in P. guineense treated Cor (1.1%) and Cor + Ama (2.5%). The activity of A. indica was independent of time of application while P. guineense was not. Among the extract treated groups, the highest percentage increase in shoot weight (71.0%), marketable yield (53.9%) and total biomass (51.5%) was in A. indica treated Cor. The activity of the extracts against insect pests of sole cropped Cor increased significantly (p < 0.05) with increasing extract concentration. The highest efficiency with the use of P. guineense was 250 g dm -3 at four, five and six WAP (94.0, 92.7 and 90.3%, respectively) and 200 mg dm -3 at seven WAP (81.7%). In the case of A. indica extract, the highest efficiency was found with the use of 200 g dm -3 at four, six and seven WAP (92.7, 85.3 and 100%, respectively). A. indica extract (250 g dm -3 ) treatment gave the highest efficiency at five WAP (100%).

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Inhibition of the growth and development of asexual and sexual stages of drug-sensitive and resistant strains of the human malaria parasite Plasmodium falciparum by Neem (Azadirachta indica) fractions

Cited by 69 publications

References 18 publications

In vitro inhibition of Plasmodium falciparum early and late stage gametocyte viability by extracts from eight traditionally used South African plant species

In vitro inhibition of Plasmodium falciparum early and late stage gametocyte viability by extracts from eight traditionally used South African plant species

Prevention of sporogony of Plasmodium vivax in Anopheles dirus mosquitoes by transmission-blocking antimalarials.

Effect of mixed cropping and plant extracts on the growth, yield and pest control of jute (Corchorus olitorius L.)

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