Inhibition of the growth of human dermatophytic pathogens by selected australian and asian plants traditionally used to treat fungal infections

Noé, W.; Murhekar, Shweta; White, Alan; Davis, C.; Cock, Ian Edwin

doi:10.1016/j.mycmed.2019.05.003

Cited by 19 publications

(14 citation statements)

References 30 publications

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“…Based on the microscopic characteristics, dermatophytes are classified as Epidermophyton, Microsporum, and Trichophyton species. The Syzygiumjambos L. (Alston) species has traditional therapeutic action and treats dermatophytosis in Southeast Asia [14].…”

Section: Dermatophytosismentioning

confidence: 99%

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Nanoarchitectures in Management of Fungal Diseases: An Overview

Mishra

Singh

Mishra³

et al. 2021

Applied Sciences

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Fungal infections, from mild itching to fatal infections, lead to chronic diseases and death. Antifungal agents have incorporated chemical compounds and natural products/phytoconstituents in the management of fungal diseases. In contrast to antibacterial research, novel antifungal drugs have progressed more swiftly because of their mild existence and negligible resistance of infections to antifungal bioactivities. Nanotechnology-based carriers have gained much attention due to their magnificent abilities. Nanoarchitectures have served as excellent carriers/drug delivery systems (DDS) for delivering antifungal drugs with improved antifungal activities, bioavailability, targeted action, and reduced cytotoxicity. This review outlines the different fungal diseases and their treatment strategies involving various nanocarrier-based techniques such as liposomes, transfersomes, ethosomes, transethosomes, niosomes, spanlastics, dendrimers, polymeric nanoparticles, polymer nanocomposites, metallic nanoparticles, carbon nanomaterials, and nanoemulsions, among other nanotechnological approaches.

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Section: Dermatophytosismentioning

confidence: 99%

“…It is also called Tinea pedisis, a familiar fungal infection that affects the foot area of the body. Generally, it relates to sports areas because the fungus propagates entirely in a warm and humid environment-for example, sports equipment, shoes, socks, locker rooms, and moist clothes [14].…”

Section: Athlete's Footmentioning

confidence: 99%

Nanoarchitectures in Management of Fungal Diseases: An Overview

Mishra

Singh

Mishra³

et al. 2021

Applied Sciences

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“…Phytochemical analysis of the kale and spirulina extracts for the presence of saponins, phenolic compounds, flavonoids, phytosteroids, triterpenoids, cardiac glycosides, anthraquinones, tannins and alkaloids was conducted using standard assays. [39][40][41]…”

Section: Qualitative Phytochemical Studiesmentioning

confidence: 99%

An Examination of the Antioxidant Capacity, Antibacterial Activity and Toxicity of Commercial Kale and Spirulina Powders

Blanc¹,

Cock²

2021

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Introduction:The development of antibiotic resistant bacteria has resulted in treatment failure for the current antibiotic regimen against many bacteria. A corresponding decrease in the development of new antibiotic therapies has highlighted the urgent need for the discovery of new antibiotics. An examination of 'superfoods' is an attractive option due to the high antioxidant capacities and beneficial secondary compounds reported in many 'superfoods'. This study was undertaken to test kale and spirulina extracts for the ability to inhibit the growth of a panel of bacterial pathogens of human importance. Methods: Commercially sourced kale and spirulina powders were extracted and tested for antimicrobial activity using modified disc diffusion and liquid dilution MIC methods. Toxicity was evaluated using an Artemia franciscana nauplii bioassay. Results: The methanolic and aqueous extracts of kale and spirulina displayed noteworthy growth inhibitory activity against P. mirabilis. The aqueous spirulina extract was a particularly good inhibitor of P. mirabilis, with MIC values as low as 220μg/mL. In contrast, all extracts were ineffective or of low inhibitory activity against all other bacteria tested. All extracts were non-toxic in the Artemia nauplii bioassay, confirming their suitability as natural antibacterial therapies. Conclusion: These studies indicate that aqueous kale and spirulina extracts are promising inhibitors of P. mirabilis growth and may be useful in the prevention and treatment of rheumatoid arthritis, as well as other diseases caused by that bacterium.

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“…Phytochemical analyses of the A. latifolia leaf extracts for the presence of saponins, phenolic compounds, flavonoids, phytosteroids, triterpenoids, cardiac glycosides, anthraquinones, tannins and alkaloids were conducted by standard assays. [33][34][35] Antibacterial screening…”

Section: Qualitative Phytochemical Studiesmentioning

confidence: 99%

Astrotrichia latifolia Benth. Leaf Extracts Lack Antibacterial Activity and are Non-toxic in vitro

Mpala¹,

Chikowe²,

Cock³

2021

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Introduction:The recent development of extensively antibiotic resistant bacteria has necessitated the search for novel antibacterial compounds. An examination of aromatic plants and traditional medicines is an attractive option for drug discovery. Astrotrichia latifolia Benth. is a native Australia shrub that has yet to be tested for antibacterial activity. Methods: The ability of A. latifolia leaf extracts to inhibit the growth of a panel of bacterial pathogens was investigated by disc diffusion assay. Toxicity was examined using the Artemia franciscana nauplii bioassay. Results: A. latifolia leaf methanolic and aqueous extracts were completely ineffective at inhibiting the growth of gram-positive and gram-negative panels of bacteria. The extracts were non-toxic in the Artemia nauplii bioassay following 24 h exposure. Conclusion: A. latifolia leaf extracts were completely ineffective bacterial growth inhibitors. However, these extracts may have other therapeutic properties and testing against protozoa, virus and tumour cells is required.

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Inhibition of the growth of human dermatophytic pathogens by selected australian and asian plants traditionally used to treat fungal infections

Cited by 19 publications

References 30 publications

Nanoarchitectures in Management of Fungal Diseases: An Overview

Nanoarchitectures in Management of Fungal Diseases: An Overview

An Examination of the Antioxidant Capacity, Antibacterial Activity and Toxicity of Commercial Kale and Spirulina Powders

Astrotrichia latifolia Benth. Leaf Extracts Lack Antibacterial Activity and are Non-toxic in vitro

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