Inhibition of the preovulatory LH surge after a catecholestrogen (2-hydroxyestrone) antiserum injection in the third ventricle of cycling female rats

Villard, Marie-Francoise; Ladosky, W.; Janots, Dominique; Lenoir, Véronique; Adeline, J.; Kerdelhué, B.; Scholler, R

doi:10.1016/0304-3940(87)90631-8

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…There have been a number of reports that catecholestrogens may influence the modulation of pituitary leuteinizing hormone (LH) release by acting on hypothalamic catecholaminergic neuroendocrine mechanisms (Ball and Knuppen, 1990;Hiemke and Ghraf, 1982;Kirchhoff et al, 1981Kirchhoff et al, , 1983Ladosky et al, 1983;Melrose and Gross, 1987;Panek and Dixon, 1986;Parvizi and Wuttke, 1983;Villard et al, 1987;Zhu and Liehr, 1993). These observations are not inconsistent with the possibility of sex differences in the rate of formation of catecholestrogens by CYP1B1, but offer no direct evidence for this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Sex differences in cytochrome P450 1B1, an estrogen-metabolizing enzyme, in the rhesus monkey telencephalon

Scallet

Muskhelishvili

Slikker

et al. 2005

Journal of Chemical Neuroanatomy

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Section: Discussionmentioning

confidence: 99%

Sex differences in cytochrome P450 1B1, an estrogen-metabolizing enzyme, in the rhesus monkey telencephalon

Scallet

Muskhelishvili

Slikker

et al. 2005

Journal of Chemical Neuroanatomy

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“…Immunocytochemical evidence of catechol estrogens in reactive cells was spread diffusely throughout the cytoplasm but was absent from the nucleus. This result suggests that, perhaps, catechol estrogens bind to certain proteins, such as globulins, which are well known to bind estrogens in the bloodstream Catechol estrogens can cause elevation and/or suppression of serum levels of luteinizing hormone (LH) and prolactin under different conditions related to age, sex, gonadal status, species, etc (1,8,14,31,32,37,45,49,54). The possible involvement of catechol estrogens in the reactive cells of the median eminence in the mechanism of secretion of LH or prolactin presents a very interesting question.…”

Section: Discussionmentioning

confidence: 99%

Immunocytochemical localization of catechol estrogens in the rat pituitary gland. II. Median eminence.

Inoue

Yoshizawa

1989

Acta Histochem. Cytochem

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Light and electron microscopic immunocytochemical observations of catechol estrogens in the median eminence of the rat were made using a specific antibody raised against 2-hydroxyestrone coupled to bovine serum albumin and the peroxidase-antiperoxidase technique. Immunoreactive deposits were found in the tanycytes and glia cells. The terminal processes of the reactive cells ended in the perivascular space. Catechol estrogen can cause elevation and/or suppression of serum levels of luteinizing hormone (LH). Thus, our results suggest that catechol estrogens in the reactive cells may be involved in the regulation of secretion of luteinizing hormone releasing hormone (LHRH) in the median eminence.Catechol estrogens are the end products of the biotransformation of estrogen in man and rat. Parvizi and Ellendorff (40) initially demonstrated the action of catechol estrogens by showing that the secretion of luteinizing hormone (LH) by the anterior pituitary is inhibited by microinjection of 2-hydroxyestradiol (2-OHE2) in the amygdala of the miniature pig. They mentioned that it remained to be established whether 2-OHE2 can cross the blood-brain barrier or whether it is synthesized in the brain, or both. Subsequently, several authors reported that estrogens are hydroxylated to become Catechol estrogens in the brain as well as in the liver (2, 12, 13, 42). The arcuatemedian eminence region, in particular, contained the highest levels of activity of estrogen 2,4-hydroxylase in rat brain (56). Furthermore, the metabolic clearance rate of catechol estrogens in the bloodstream is very high (28). Consequently, catechol estrogens in the bloodstream are assumed not to produce any local effects in the brain. Despite much speculation, the mechanism of the action of catechol estrogens in the brain remains unknown. The specific localization of catechol estrogens might give further clues to their function. We have already reported that the localization of catechol estrogens can be determined by immunocytochemical methods (19, 20). In the present study we examined the distribution of catechol estrogens in the median eminence of the rat. The tanycytes and the glia cells in median eminence were all found to contain catechol estrogens.

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Inhibition of catechol estrogen formation in rat liver microsomes by hormonal steroids and related compounds

Quail

Newcombe

Jellinck

1988

Journal of Steroid Biochemistry

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Inhibition of the preovulatory LH surge after a catecholestrogen (2-hydroxyestrone) antiserum injection in the third ventricle of cycling female rats

Cited by 4 publications

References 18 publications

Sex differences in cytochrome P450 1B1, an estrogen-metabolizing enzyme, in the rhesus monkey telencephalon

Sex differences in cytochrome P450 1B1, an estrogen-metabolizing enzyme, in the rhesus monkey telencephalon

Immunocytochemical localization of catechol estrogens in the rat pituitary gland. II. Median eminence.

Inhibition of catechol estrogen formation in rat liver microsomes by hormonal steroids and related compounds

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