Inhibition of the procoagulant activity of blood platelets by vinylsulfonyl derivatives of pyrrolidine-2-carboxylic acid

Abstract

Novel derivatives of 4 (vinylsulfonyl)pyrrolidine 2 carboxylic acids inhibit the exposure of phosphatidylserine by platelets upon activation with thrombin. The heterocyclic inhibitors were synthesized by 1,3 dipolar cycloaddition of divinyl sulfone to azomethine ylides followed by functionalization of the endocyclic nitrogen atom.