Inhibition of Thyrocyte lodide Uptake by H+K+ATPase Inhibitor, Timoprazole.

H(+)/K(+)-ATPase modulators have attracted much interest for their clinical implication in gastric acid-related diseases. Future studies of gastric H(+)/K(+)-ATPase inhibitors may focus on the correlation of pharmacogenetics and pharmacogenomics with the gastric acid secretion and development of more effective H(+)/K(+)-ATPase inhibitors to increase their residence time such as tenatoprazole and novel chemical-mediated absorption chemicals. The K(+)-competitive acid pump antagonists (APAs) are invented and independent of an acidic environment with better inhibition of the pump rapidly control acid secretion with a larger extent. The most innovative and promising compounds of APAs is AZD-0865, which is a modification of SCH28080. H(+)/K(+)-ATPase inhibitors can be tried to treat other diseases, especially viral infection after numerous clinical trials, and respiratory disease.

show abstract

H⁺/K⁺-ATPase inhibitors: a patent review

Meng

Liu

et al. 2012

Expert Opinion on Therapeutic Patents

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Inhibition of Thyrocyte lodide Uptake by H+K+ATPase Inhibitor, Timoprazole.

Abstract: Abstract.The inhibitory effect of timoprazole on iodide uptake by cultured thyrocytes was observed using FRTL-5 cells.

Cited by 1 publication

References 17 publications

H⁺/K⁺-ATPase inhibitors: a patent review

H⁺/K⁺-ATPase inhibitors: a patent review

Contact Info

Product

Resources

About

Inhibition of Thyrocyte lodide Uptake by H+K+ATPase Inhibitor, Timoprazole.

Abstract: Abstract.The inhibitory effect of timoprazole on iodide uptake by cultured thyrocytes was observed using FRTL-5 cells.

Cited by 1 publication

References 17 publications

H+/K+-ATPase inhibitors: a patent review

H+/K+-ATPase inhibitors: a patent review

Contact Info

Product

Resources

About

H⁺/K⁺-ATPase inhibitors: a patent review

H⁺/K⁺-ATPase inhibitors: a patent review