Inhibition of TREM-1 alleviates neuroinflammation by modulating microglial polarization via SYK/p38MAPK signaling pathway after traumatic brain injury

Zhao, Tianqi; Zhou, Yuxin; Zhang, Dabing; Han, Dong; Ma, Jingyuan; Li, Shanshan; Li, Ting; Hu, Shuqun; Li, Zhouru

doi:10.1016/j.brainres.2024.148907

Brain Research

2024

DOI: 10.1016/j.brainres.2024.148907

|View full text |Cite

Inhibition of TREM-1 alleviates neuroinflammation by modulating microglial polarization via SYK/p38MAPK signaling pathway after traumatic brain injury

Tianqi Zhao,

Yuxin Zhou,

Dabing Zhang

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

TREM1—Microglia crosstalk: Neurocognitive disorders

Li,

Yu,

Zheng

et al. 2025

Brain Research Bulletin

View full text Add to dashboard Cite

TREM1—Microglia crosstalk: Neurocognitive disorders

Li,

Yu,

Zheng

et al. 2025

Brain Research Bulletin

View full text Add to dashboard Cite

Role of triggering receptor expressed on myeloid cells 1/2 in secondary injury after cerebral hemorrhage

Yi,

Wu,

Zhao

2025

World J Clin Cases

View full text Add to dashboard Cite

Intracerebral hemorrhage (ICH) is a common severe emergency in neurosurgery, causing tremendous economic pressure on families and society and devastating effects on patients both physically and psychologically, especially among patients with poor functional outcomes. ICH is often accompanied by decreased consciousness and limb dysfunction. This seriously affects patients’ ability to live independently. Although rapid advances in neurosurgery have greatly improved patient survival, there remains insufficient evidence that surgical treatment significantly improves long-term outcomes. With in-depth pathophysiological studies after ICH, increasing evidence has shown that secondary injury after ICH is related to long-term prognosis and that the key to secondary injury is various immune-mediated neuroinflammatory reactions after ICH. In basic and clinical studies of various systemic inflammatory diseases, triggering receptor expressed on myeloid cells 1/2 (TREM-1/2), and the TREM receptor family is closely related to the inflammatory response. Various inflammatory diseases can be upregulated and downregulated through receptor intervention. How the TREM receptor functions after ICH, the types of results from intervention, and whether the outcomes can improve secondary brain injury and the long-term prognosis of patients are unknown. An analysis of relevant research results from basic and clinical trials revealed that the inhibition of TREM-1 and the activation of TREM-2 can alleviate the neuroinflammatory immune response, significantly improve the long-term prognosis of neurological function in patients with cerebral hemorrhage, and thus improve the ability of patients to live independently.

show abstract

TREM-1 and TREM-2 as therapeutic targets: clinical challenges and perspectives

Sigalov

2024

Front. Immunol.

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Inhibition of TREM-1 alleviates neuroinflammation by modulating microglial polarization via SYK/p38MAPK signaling pathway after traumatic brain injury

Cited by 3 publications

References 53 publications

TREM1—Microglia crosstalk: Neurocognitive disorders

TREM1—Microglia crosstalk: Neurocognitive disorders

Role of triggering receptor expressed on myeloid cells 1/2 in secondary injury after cerebral hemorrhage

TREM-1 and TREM-2 as therapeutic targets: clinical challenges and perspectives

Contact Info

Product

Resources

About