Inhibition of trigemino-hypoglossal reflex in rats by oxytocin is mediated by μ and κ opioid receptors

Zubrzycka, Maria; Fichna, Jakub; Janecka, Anna

doi:10.1016/j.brainres.2004.11.045

Cited by 17 publications

(6 citation statements)

References 32 publications

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“…There is evidence that OT interacts with the opioid system during pain alleviation (Yang, 1994;Zubrzycka et al, 2005;Taati and Tamaddonfard, 2017) which may, at least partially, underlie OT's pain-alleviating function. For example, intrathecal OT increased spinal-cord levels of beta-endorphin, L-encephalin, and dynorphin A1-13 with analgesia in both human patients with acute and chronic low back pain as well as in rats (Yang, 1994).…”

Section: Interactions With the Opioid Systemmentioning

confidence: 99%

“…For example, concurrent NSAID use may interfere with OT's analgesic effects (Kwong and Chan, 2015), as OXTR expression may be, at least partially, driven by inflammatory cytokine presence (Terzidou et al, 2011). Further, OT potentially interacts with the opioid system during pain alleviation (Yang, 1994;Zubrzycka et al, 2005;Taati and Tamaddonfard, 2017) and decreased opioid tolerance in animal models (Kovács et al, 1985;Kriván et al, 1992). In addition, interactions have been found between the OT system with neurotransmitter systems including dopamine (Baskerville and Douglas, 2010) and potentially serotonin (Bakermans-Kranenburg and van IJzendoorn, 2008).…”

Section: Concurrent and Adjunct Treatmentmentioning

confidence: 99%

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Musculoskeletal Pain and Brain Morphology: Oxytocin’s Potential as a Treatment for Chronic Pain in Aging

Lussier

Cruz-Almeida

Ebner

2019

Front. Aging Neurosci.

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Chronic pain disproportionately affects older adults, severely impacting quality of life and independent living, with musculoskeletal pain most prevalent. Chronic musculoskeletal pain is associated with specific structural alterations in the brain and interindividual variability in brain structure is likely an important contributor to susceptibility for the development of chronic pain. However, understanding of age-related structural changes in the brain and their associations with chronic musculoskeletal pain is currently limited. Oxytocin (OT), a neuropeptide present in the periphery and central nervous system, has been implicated in pain attenuation. Variation of the endogenous OT system (e.g., OT receptor genotype, blood, saliva, and cerebrospinal fluid OT levels) is associated with morphology in brain regions involved in pain processing and modulation. Intranasal OT administration has been shown to attenuate pain. Yet, studies investigating the efficacy of OT for management of chronic musculoskeletal pain are lacking, including among older individuals who are particularly susceptible to the development of chronic musculoskeletal pain. The goal of this focused narrative review was to synthesize previously parallel lines of work on the relationships between chronic pain, brain morphology, and OT in the context of aging. Based on the existing evidence, we propose that research on the use of intranasal OT administration as an intervention for chronic pain in older adults is needed and constitutes a promising future direction for this field. The paper concludes with suggestions for future research in the emerging field, guided by our proposed Model of Oxytocin's Anagelsic and Brain Structural Effects in Aging.

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Section: Interactions With the Opioid Systemmentioning

confidence: 99%

Section: Concurrent and Adjunct Treatmentmentioning

confidence: 99%

Musculoskeletal Pain and Brain Morphology: Oxytocin’s Potential as a Treatment for Chronic Pain in Aging

Lussier

Cruz-Almeida

Ebner

2019

Front. Aging Neurosci.

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“…OXY administered systemically or at CNS sites such as the spinal intrathecal space [112], PAG [53,54], caudate nucleus [113], nucleus accumbens [114] and amygdala [115] produces analgesia in rodents. Specifically, studies examining the effects of OXY administration have shown rats to be less sensitive to electrical, thermal, chemical and mechanical pain stimuli [49, 116–125], and to also have less pain following acute stress [75], acute inflammation [50,112,126–129], tooth pulp stimulation [108, 109, 130] and neuropathic injury [131,132]. In most cases, this analgesia was reversed with OXTR antagonists.…”

Section: Oxytocin Inhibits Somatic Nociceptionmentioning

confidence: 99%

“…OXTR knockout mice had heat and mechanical pain tolerances that were similar to wild-type mice, but the OXTR knockout mice did demonstrate reduced pain tolerance following swim and restraint stressors [121]. Opioidergic, cannabinoid-related, and galanin-related systems have been implicated in central OXY-related analgesia [49–51,54,120,128,130,138]. However, several studies have failed to observe any effect of naloxone treatment on OXY-related analgesia, and so also proposed non-opioidergic effects [e.g.…”

Section: Oxytocin Inhibits Somatic Nociceptionmentioning

confidence: 99%

Oxytocin - A Multifunctional Analgesic for Chronic Deep Tissue Pain

Goodin

Ness²,

Robbins³

2014

CPD

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The treatment of chronic pain arising from deep tissues is currently inadequate and there is need for new pharmacological agents to provide analgesia. The endogenous paracrine hormone/neurotransmitter oxytocin is intimately involved in the modulation of multiple physiological and psychological functions. Recent experiments have given clear evidence for a role of oxytocin in the modulation of nociception. The present article reviews the existent human and basic science data related to the direct and indirect effects of oxytocin on pain. Due to its analgesic, anxiolytic, antidepressant and other central nervous system effects, there is strong evidence that oxytocin and other drugs acting through the oxytocin receptor could act as multifunctional analgesics with unique therapeutic value.

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“…Although some studies indicated that there are interaction opioid system and oxytocin receptors, this was unclear and limited 8,9 . Our aim in this study was to investigate the effects of oxytocin receptor antagonist atosiban on oxytocin antinociceptive effect and morphine analgesia.…”

Section: Introductionmentioning

confidence: 99%

Effects of oxytocin and oxytocin receptor antagonist atosiban on nociception and morphine analgesia in rats

Taşkıran

Özdemir²,

Güneş³

et al. 2017

Cumhuriyet Medical Journal

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SUMMARYObjective: Oxytocin is a peptide-based hormone released from the supraoptic nucleus and paraventricular nucleus in the hypothalamus and consisting of nine amino acids. It has been shown that oxytocin may have an effect on opiate receptors. Atosiban is a oxytocin receptor antagonist. Our aim in this study was to investigate the effects of oxytocin and atosiban on nociception and morphine analgesia. Method: In our study, 48 Wistar Albino 230-260 g male rats were used. The animals were divided into eight groups (control, 200 μg/kg oxytocin, 3 mg/kg atosiban, oxytocin+ atosiban, 5 mg/kg morphine, morphine+ oxytocin, morphine+atosiban and morphine+ oxytocin+ atosiban). Serum physiologic to the control group, oxytocin and atosiban were given intraperitoneally (i.p.) at the indicated doses to the other groups. Morphine was administered subcutaneously (s.c.). Analgesic effects were assessed by hot plate and tail flick analgesia tests. The resulting analgesic effect was measured and recorded at the 15th, 30th, 60th, 90th and 120th minutes. Assessment of analgesic effect was formulated as % analgesia (MPE) (% analgesia = 100x [post drug reaction time-pre drug reaction time]/ [cut off time-pre drug reaction time]). Results: Oxytocin showed analgesic activity (p<0,05). Atosiban showed hyperalgesic activity and decreased the analgesic activity of oxytocin when given with oxytocin (p<0,05). Oxytocin increased the analgesic activity of morphine (p<0.05). In addition, although atosiban did not alter the analgesic activity of morphine, morphine analgesia increased by oxytocin was reduced (p<0.05). Conclusions: According to these results, it can be said that although atosiban does not change on the analgesic effect of morphine alone, it blocks the effect of oxytocin on morphine analgesia. Keywords: Atosiban, oxytocin, nociception, morphine analgesia, analgesia tests ÖZET Amaç: Oksitosin, hipotalamusta supraoptik çekirdek ve paraventrikülerçekirdeklerden salınan, dokuz amino asitten oluşan, peptid yapılı bir hormondur. Oksitosin'in opiyat reseptörleri üzerinde etkili olabileceği gösterilmiştir. Atosiban, oksitosinin reseptör antagonistidir. Bu çalışmada amacımız, oksitosin ve atosibanın nosisepsiyon ve morfin analjezisi üzerine etkilerini araştırmaktır.

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Inhibition of trigemino-hypoglossal reflex in rats by oxytocin is mediated by μ and κ opioid receptors

Cited by 17 publications

References 32 publications

Musculoskeletal Pain and Brain Morphology: Oxytocin’s Potential as a Treatment for Chronic Pain in Aging

Musculoskeletal Pain and Brain Morphology: Oxytocin’s Potential as a Treatment for Chronic Pain in Aging

Oxytocin - A Multifunctional Analgesic for Chronic Deep Tissue Pain

Effects of oxytocin and oxytocin receptor antagonist atosiban on nociception and morphine analgesia in rats

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