Inhibition of Trypanosoma brucei brucei by Extracts from Waltheria indica L. (Sleepy Morning)

Bala, AY; Adamu, T; Abubakar, U.; Ladan, MJ

doi:10.3923/jp.2011.53.59

Cited by 12 publications

(11 citation statements)

References 9 publications

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“…From the findings in this study, it is reasonable to infer that T. brucei infection causes significant decrease in the serum levels of cholesterol, high density lipoprotein, triacylglycerol and low density lipoprotein. The findings in this study are in conformity with other reports [33][34][35][36] . Although we cannot ascertain the reasons for the sudden drop, some pathophysiological mechanisms may be involved.…”

Section: Discussionsupporting

confidence: 94%

Anti–trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei–infected rats

Abimbola

Baba

Yenusa

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionsupporting

confidence: 94%

Anti–trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei–infected rats

Abimbola

Baba

Yenusa

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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“…The in vitro test carried out in the study showed the advantages of being simple to perform, relatively inexpensive, re- (Cowan, 1999) and especially on trypanosomes (Bala et al, 2010). Compared to these active extracts, those of Mitragyna inermis and B. aegyptiaca leaves showed a weak trypanocidal effect only at the concentration of 100 mg/ml on T. b. brucei.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Trypanosoma brucei brucei and Potential In Vitro Trypanocidal Activity of Aqueous Extracts of Some Medicinal Plants in the Pastoral Area of Gaongho in Burkina Faso

André¹,

Kaboré²,

Zakaria³

et al. 2017

J. Anim. Health Prod.

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| In the pastoral zone of Gaongho in Burkina Faso, the main disease of ruminants is the African Animal Trypanosomiasis (AAT) which is very often controlled by herders with the aqueous extracts of five plants whose present study proposes to evaluate the potential trypanocidal activities. To this end, a parasitological field survey in ruminants was carried out followed by an in vitro trypanocidal test of five plant extracts using three concentrations (25, 50 and 100 mg / ml) in triplicate in comparison with negative (PBS) and positive (Veriben) controls in the laboratory. The field survey revealed an overall prevalence rate of 4.14% for trypanosomes, including 4.54% for cattle and sheep and 3.33% for goats, with no significant difference (P ˃ 0. 05) was recorded between the three ruminant species. Among the latter, the sex effect showed a significant difference in goats where males were more infested (P = 0.0015) than females. On the other hand, the age of the animals presented no significant difference (P = 0.8218) between the three species. All ruminants tested were more infested with Trypanosoma brucei brucei (66.67%) than T. congolense (33.33%). The in vitro test was conducted with aqueous extracts of five plants (Balanites aegyptiaca, Capparis sepiaria, Guiera senegalensis, Mitragyna inermis, and Vitellaria paradoxa) on Trypanosoma brucei brucei. Concentrations of 50 and 100 mg / ml of G. senegalensis leaf extracts and V. paradoxa bark caused high mortality of T. brucei brucei and were comparable to Veriben, the standard reference product. The results obtained with the extracts of G. senegalensis and V. paradoxa showed that these plantsmay be the potential source of trypanocidal drugs. Keywords

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“…The Fulani group uses the root aqueous extract for treating internal hemorrhage, syphilis, and relieving pains and aches. It is also used as a restorative agent during the labors of harvesting by the Yorub [46,65].…”

Section: Traditional Usesmentioning

confidence: 99%

“…Maregesi et al [86] reported that the water-methanol (80%) shoot extract showed anti-plasmodial activity with IC 50 between 125 and 250 μg/mL [6]. Bala et al [65] found the inhibitory activity of polar ethanolic whole plant extract against Trypanosoma brucei brucei (T. b. brucei) was higher than nonpolar petroleum ether extracts. Cretton et al [61,82] tested dichloromethane root extract against T. cruzi, T. b. brucei STIB 427 strain and T. brucei rhodesiense STIB 900.…”

Section: Anti-parasitic Activitymentioning

confidence: 99%

Ethnobotanical, phytochemistry, and pharmacological property of Waltheria Indica Linn

Nirmala

Sridevi

2021

Futur J Pharm Sci

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Background In modern therapeutics, various human pathological disturbances were treated with the plant-based products. Waltheria indica Linn, a perennial herb, was commonly used in traditional medicine worldwide against various ailments such as cough, dysentery, diarrhea, bladder disorder, hemoptysis, inflammations, neuralgia, wounds, and ulcers. Main body The shrub was majorly distributed in tropical, subtropical regions and exists in many distinct local forms. Both the crude extracts and purified compounds from the whole plant and its parts showed wide pharmacological properties like antioxidant, analgesic, sedative, anti-bacterial, anti-fungal, and anti-parasitic. The phytochemical profile and traditional usage highlight the potency of the plant in the treatment of microbial infections and inflammatory diseases. Yet, additional studies are required for the confirmations of its traditional uses against other diseases. More detailed understanding of anti-cataract, anti-diabetics, asthma, anemia, and anti-cancer mechanism has to be explored. Though many research articles on the proposed plant are available, there has been a rising concern in the therapeutic property, especially on the alkaloids and flavonoids from this plant for drug design. Conclusion This article aims in a systematic and updated review on distribution, botany, traditional uses, phytocompounds, and relevant biological activities from each part of the plant. The information was collected from databases like PubMed, ScienceDirect, Web of Science, Google Scholar, books, dissertation, and reports via academic libraries that included more than 100 articles published since 1937. This ethnopharmacological study of the plant may create new insight into drug discovery to develop important novel leads against various biological targets.

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Inhibition of Trypanosoma brucei brucei by Extracts from Waltheria indica L. (Sleepy Morning)

Cited by 12 publications

References 9 publications

Anti–trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei–infected rats

Anti–trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei–infected rats

Prevalence of Trypanosoma brucei brucei and Potential In Vitro Trypanocidal Activity of Aqueous Extracts of Some Medicinal Plants in the Pastoral Area of Gaongho in Burkina Faso

Ethnobotanical, phytochemistry, and pharmacological property of Waltheria Indica Linn

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