2005
DOI: 10.1007/s00011-005-0003-7
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Inhibition of tumor necrosis factor-α-induced intercellular adhesion molecule-1 expression in diabetic rats: role of insulin

Abstract: Insulin modulates TNF-alpha-induced ICAM-1 expression on microvascular endothelium controlling, therefore, leukocyte adhesion and migration.

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Cited by 35 publications
(30 citation statements)
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(50 reference statements)
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“…Under the influence of an inflammatory stimulus, only few leukocytes accumulate in the perivascular tissue of diabetic rats in contrast to the massive number of leukocytes that normally emerge into the tissue around a vessel (12). These abnormalities are not related to changes in mean arterial pressure and heart rate values, blood flow velocity, venular shear rate, or blood glucose levels (15). Treatment of diabetic animals with insulin completely reverses defective leukocyte-endothelial interactions.…”
Section: Neutrophil Function In Diabetes Mellitusmentioning
confidence: 87%
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“…Under the influence of an inflammatory stimulus, only few leukocytes accumulate in the perivascular tissue of diabetic rats in contrast to the massive number of leukocytes that normally emerge into the tissue around a vessel (12). These abnormalities are not related to changes in mean arterial pressure and heart rate values, blood flow velocity, venular shear rate, or blood glucose levels (15). Treatment of diabetic animals with insulin completely reverses defective leukocyte-endothelial interactions.…”
Section: Neutrophil Function In Diabetes Mellitusmentioning
confidence: 87%
“…The impaired local exudative cellular reaction in alloxan-induced diabetic rats is a consequence of defective leukocyte-endothelial interactions (11,12,15). Intravital microscopic examination of the internal spermatic fascia microcirculatory network showed that a reduced number of leukocytes rolling along the venular endothelium is observed from the early stages of diabetes.…”
Section: Neutrophil Function In Diabetes Mellitusmentioning
confidence: 99%
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“…A eutanásia foi realizada 16 horas após a última dose de insulina (ANJOS-VALOTTA et al, 2006;DI PETTA et al, 2011, modificado). Neste caso, a glicemia foi determinada antes da eutanásia.…”
Section: Protocolos De Tratamento Com Insulinaunclassified