2009
DOI: 10.1167/iovs.08-2662
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Inhibition of Vascular Endothelial Growth Factor Reduces Scar Formation after Glaucoma Filtration Surgery

Abstract: VEGF was upregulated in the aqueous humor of glaucoma patients and in the rabbit model, and it stimulated fibroblast proliferation in vitro. This suggests that it is involved in the scarring process after filtration surgery. Bevacizumab reduced the proliferation of fibroblasts in vitro and improved surgical outcome.

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Cited by 210 publications
(228 citation statements)
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“…19 A growing number of studies have been published that focus on angiogenesis as a potential target for increasing the surgical success associated with routine trabeculectomies; these studies mainly focus on the effects of bevacizumab and ranibizumab. [9][10][11]20 The dose, route of administration, and new drug release mechanisms should be studied to improve the effectiveness of a bevacizumab-augmented trabeculectomy to reduce fibrosis. Several issues need to be addressed regarding the offlabel use of bevacizumab, such as the duration of action of the drug and its toxicity profile in ocular tissues.…”
Section: Discussionmentioning
confidence: 99%
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“…19 A growing number of studies have been published that focus on angiogenesis as a potential target for increasing the surgical success associated with routine trabeculectomies; these studies mainly focus on the effects of bevacizumab and ranibizumab. [9][10][11]20 The dose, route of administration, and new drug release mechanisms should be studied to improve the effectiveness of a bevacizumab-augmented trabeculectomy to reduce fibrosis. Several issues need to be addressed regarding the offlabel use of bevacizumab, such as the duration of action of the drug and its toxicity profile in ocular tissues.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, these cells also express these cognate VEGF receptors. 11,25 Other systems that permit the sustained release of bevacizumab have been described by Abrishami et al 26 and Andrew et al, 27 but these systems utilized a liposomal delivery system (nanoliposomes) and an inorganic polymer (mesoporous silicon oxide), respectively. They were developed to treat diseases of the posterior segment of the FIG.…”
Section: Paula Et Almentioning
confidence: 99%
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“…O grau de inflamação foi avaliado visto que existem estudos que, apesar da droga não apresentar efeitos anti-inflamatórios diretos, mostram evidencias de um efeito em fibroblastos (21)(22) . A ação na inflamação aguda ainda não havia sido estudada mais profundamente, sendo sugerido uma diminuição na invasão de neutrófilos na ferida (23) .…”
Section: Discussionunclassified
“…In fact, with the existance of a filtering pathway, the drug might flow to the subconjunctival space, and subconjunctival bevacizumab has been suggested to reduce scar formation of the bleb. 11,12 In conclusion, we suggest immediate combined surgery for NVG, which includes trabeculectomy with mitomycin C, PPV with endolaser PRP, IVB and ICB. This strategy has shown to be successful in controlling IOP and preserving useful vision.…”
Section: -5mentioning
confidence: 93%