Inhibition of Wound Healing by Topical Anti-microbial Agents

Niedner, R.

doi:10.1007/978-3-642-77882-7_41

Cited by 1 publication

(10 citation statements)

References 19 publications

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“…Experimental studies as well as clinical experience demonstrate that various endogenous and exogenous factors may induce impaired wound healing. Niedner 4 postulated that the normal healing process cannot be accelerated by topical wound treatment, and that various common treatment regimes may even induce further delay in the healing process.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, such agents are frequently employed in chronically infected wounds. Niedner 4 and Niedner & Schöpf 14 described inhibition of wound healing by triphenylmethane dyes, such as gentian violet B and brilliant green. Because of this and the possibility of cytotoxic effects, Niedner 4 proposed that dyes such as gentian violet B should be avoided in the treatment of open wounds.…”

Section: Discussionmentioning

confidence: 99%

“…Niedner 4 and Niedner & Schöpf 14 described inhibition of wound healing by triphenylmethane dyes, such as gentian violet B and brilliant green. Because of this and the possibility of cytotoxic effects, Niedner 4 proposed that dyes such as gentian violet B should be avoided in the treatment of open wounds. However, eosin, which caused only slight retardation of healing, 4 and has bacteriostatic activity when used at 2% in conjunction with UV radiation, 15 may be a suitable agent for topical wound treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Historically, the introduction of antiseptic agents and the use of antibiotics were the first steps in the successful treatment of infected wounds 2 . 4 …”

Section: Introductionmentioning

confidence: 99%

“…Studies with keratinocytes cultured on feeder layers of mesenchymal cells are frequently used to demonstrate the effects of test compounds on epidermal proliferation 5 . 6 In animal studies, small laboratory animals (mice, rats, guinea pigs) are frequently used 4 . 7 , 8 Large animals, such as pigs or horses, are used occasionally 9 .…”

Section: Introductionmentioning

confidence: 99%

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Improvement and retardation of wound healing: effects of pharmacological agents in laboratory animal studies

Kietzmann

1999

Veterinary Dermatology

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Impaired wound healing is an important problem; retardation of healing may be induced by endogenous and/or exogenous factors and treatments capable of ameliorating these eects are needed. The eects of solutions containing light ichthyol or povidone iodine, of ointments containing zinc oxide (ZO) and/ or cod liver oil (CLO), and of a polyurethane-hydrogel foam wound dressing were examined on healing of full-thickness murine skin wounds impaired by systemic dexamethasone. The eects of the ointments were also studied on murine skin ulceration induced by subcutaneous sodium dodecyl sulphate solution. Light ichthyol at 1% and 2% but not at 5% and 10%, povidone iodine at 1% and the foam accelerated impaired healing. The ointments containing ZO or CLO accelerated healing of impaired full-thickness wounds and of ulcerated skin; ZO and CLO were synergistic. These studies demonstrate the value of murine models in the evaluation of agents employed in veterinary wound dressings.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Historically, the introduction of antiseptic agents and the use of antibiotics were the first steps in the successful treatment of infected wounds 2 . 4 …”

Section: Introductionmentioning

confidence: 99%