2015
DOI: 10.1084/jem.21211oia90
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Inhibition of β-catenin–TCF1 interaction delays differentiation of mouse embryonic stem cells

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Cited by 5 publications
(5 citation statements)
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“…A cut-off of twofold was used to allocate transcripts as either RA-enriched (420 transcripts) or LIF-enriched (28 transcripts). We mined publicly available transcriptome data [65] and classified transcripts that were more than twofold upregulated after RA treatment as "differentiation-responsive genes" and more than twofold downregulated as "pluripotency-associated genes". Genes that showed tsRNA/Scr1 was > 2-fold in both the LIF and RA conditions and similar enrichments in both the conditions were categorized as "Ubiquitous".…”
Section: Tsrna-mediated Mrna Pulldown Library and Analysismentioning
confidence: 99%
“…A cut-off of twofold was used to allocate transcripts as either RA-enriched (420 transcripts) or LIF-enriched (28 transcripts). We mined publicly available transcriptome data [65] and classified transcripts that were more than twofold upregulated after RA treatment as "differentiation-responsive genes" and more than twofold downregulated as "pluripotency-associated genes". Genes that showed tsRNA/Scr1 was > 2-fold in both the LIF and RA conditions and similar enrichments in both the conditions were categorized as "Ubiquitous".…”
Section: Tsrna-mediated Mrna Pulldown Library and Analysismentioning
confidence: 99%
“…In the active state, unphosphorylated β-catenin accumulates in the cytoplasm and translocates into the nucleus, acting as a central effector of the canonical Wnt signaling cascade (Wodarz and Nusse 1998). The β-catenin and nuclear transcription factor lymphoid enhancer factor/T cell factor (LEF/TCF) complex (Arce and others 2006; Bem and others 2019; Chatterjee and others 2015) determines cell proliferation and differentiation by activating a series of Wnt signaling target genes (Chatterjee and others 2015; Kalani and others 2008). Notably, the transcriptional response system responds to fold changes but not absolute levels of β-catenin (Goentoro and Kirschner 2009).…”
Section: Overview Of Wnt/β-catenin Signalingmentioning
confidence: 99%
“…Depending on the signals provided, ESCs can differentiate into a variety of cell types (Wobus and Boheler, 2005). LIF/ STAT3, WNT/b-catenin, and bone morphogenetic protein (BMP)/SMAD have been suggested as context-dependent regulators of both ESC self-renewal and differentiation (Chatterjee et al, 2015;Funa et al, 2015;Itoh et al, 2014;Niwa et al, 1998;Zhang et al, 2013). In contrast, retinoic acid (RA) is known as an efficient inducer of ESC differentiation (Gudas and Wagner, 2011;Rochette-Egly, 2015;Simandi et al, 2010).…”
Section: Introductionmentioning
confidence: 99%