Inhibition of β-Lactamase—Induced Resistance in Soft-Tissue Infections

Nichols, Ronald Lee; Smith, Jeffrey W.; Adinolfi, Michael F.; R, Galli; Vivoda, Luciana M.

doi:10.1001/archsurg.1985.01390250030005

Arch Surg

1985

DOI: 10.1001/archsurg.1985.01390250030005

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Inhibition of β-Lactamase—Induced Resistance in Soft-Tissue Infections

Ronald Lee Nichols¹,

Jeffrey W. Smith²,

Michael F. Adinolfi³

et al.

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1985

1995

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Cited by 3 publications

References 5 publications

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Ampicillin‐Sulbactam and Ticarcillin‐Clavulanic Acid: A Comparison of Their In Vitro Activity and Review of Their Clinical Efficacy

Itokazu,

Danziger

1991

Pharmacotherapy

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Sulbactam (SB) and clavulanic acid (CA) are irreversible inhibitors of the β‐lactamases in the Richmond and Sykes classes II—VI. When combined with ampicillin and ticarcillin, SB and CA, respectively, extend the spectrum of activity of these penicillins to include some β‐lactamase‐producing aerobes (Enterobacteriaceae, Hemophilus influenzae, staphylococci) and anaerobes (Bacteroides fragilis group) which would otherwise be resistant. Neither effectively inhibits the class I β‐lactamases frequently produced by Pseudomonas aeruginosa, Enierobacter, and Serratia, in part explaining the resistance observed with these organisms. Clinically, both agents were as effective as the comparative therapies in all but two of the trials reviewed. Given the current data, the decision to add these agents to the formulary should be based on hospital resistance patterns and on the cost of these antimicrobials in comparison to conventional therapies.

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Ampicillin‐Sulbactam and Ticarcillin‐Clavulanic Acid: A Comparison of Their In Vitro Activity and Review of Their Clinical Efficacy

Itokazu,

Danziger

1991

Pharmacotherapy

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The role of β-lactamase inhibitors in chemotherapy

Neu

1985

Pharmacology & Therapeutics

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Efficacy of Femoral Intra-arterial Administration of Teicoplanin in Gram-Positive Diabetic Foot Infections

Cameli

Trapani

et al. 1995

Angiology

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In this study the efficacy and safety femoral intra-arterial administration of teicoplanin in the treatment of diabetic foot infections caused by gram-positive bacteria were evaluated. Twenty-five hospitalized diabetic patients with foot ulcers or with foot ulcers and metatarsophalangeal osteomyelitis were included in the study. In the ulcers Staphylococcus aureus was present alone in 16 patients and was associated with Pseudomonas aeruginosa in 2 patients, with Candida albicans in 2, and with coagulase-negative Staphylococcus in 1 patient. In 4 patients other gram-positive bacteria were isolated. All isolated strains were resistant to various antibiotics tested. Teicoplanin, 200 mg, was administered once a day by femoral intra-arterial injection for an average period of 14.72 +/- 7.16 days (range ten to thirty-six days). Six patients were treated with an additional antibiotic intramuscularly or intravenously because of a mixed infection. At the end of the therapy microbiological assessment confirmed that gram-positive infection was eliminated in all patients. Clinical outcome demonstrated that healing occurred in 18 patients (72%) and improvement in 7 patients (28%). No adverse drug reactions were observed during the treatment. The results demonstrate that femoral intra-arterial administration of teicoplanin was highly effective in skin- and bone-infected lesions in the diabetic foot. This method may represent a further advantage in management of this severe diabetic complication.

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Inhibition of β-Lactamase—Induced Resistance in Soft-Tissue Infections

Cited by 3 publications

References 5 publications

Ampicillin‐Sulbactam and Ticarcillin‐Clavulanic Acid: A Comparison of Their In Vitro Activity and Review of Their Clinical Efficacy

Ampicillin‐Sulbactam and Ticarcillin‐Clavulanic Acid: A Comparison of Their In Vitro Activity and Review of Their Clinical Efficacy

The role of β-lactamase inhibitors in chemotherapy

Efficacy of Femoral Intra-arterial Administration of Teicoplanin in Gram-Positive Diabetic Foot Infections

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