Inhibition on angiotensin-converting enzyme exerts beneficial effects on trabecular bone in orchidectomized mice

Chen, Xiangfan; Li, Xiaoli; Liu, Jinxin; Xu, Jing; Zhao, Yanyan; Yang, Min; Zhang, Yan

doi:10.1016/j.pharep.2018.02.008

Cited by 9 publications

(7 citation statements)

References 44 publications

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“…Both issues warrant further exploration. It is tempting to speculate that the renin/angiotensin/aldosterone axis might be involved, as well (47,48).…”

Section: Discussionmentioning

confidence: 99%

Osteoprotective action of low-salt diet requires myeloid cell–derived NFAT5

Schröder¹,

Neubert²,

Titze³

et al. 2019

JCI Insight

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“…Both issues warrant further exploration. It is tempting to speculate that the renin/angiotensin/aldosterone axis might be involved, as well (47,48).…”

Section: Discussionmentioning

confidence: 99%

Osteoprotective action of low-salt diet requires myeloid cell–derived NFAT5

Schröder¹,

Neubert²,

Titze³

et al. 2019

JCI Insight

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“…Also, coadministration of estradiol and ramipril were superior to administration of each of them alone in both increase of serum RANKL and decrease of serum OPG. Also, Chen et al (24) reported that the administration with captopril in orchidectomized mice for six weeks enhanced the ratio of OPG/RANKL mRNA expression.…”

Section: Discussionmentioning

confidence: 99%

Role of 17-β Estradiol and Ramipril in OPG/RANKL Pathway in a Rat Model of Post-Menopausal Osteoporosis

Khloussy¹,

Badawy²,

Mohamed³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Primary osteoporosis and other metabolic bone disorders have been linked to the proteins osteoprotegerin (OPG) and receptor activator of nuclear factor-kappa B ligand (RANKL). Aim and objectives: Our study's goal was to examine the effects of co-administering estradiol (E2) and ramipril (ACEI) on bone markers in ovariectomized rats and to assess the potential interactions between these medications in order to address the function of the OPG/RANKL system as a potential mechanism of action. Materials and methods: 40 female rats, randomly divided into 5 groups, each group included 8 rats.  Group 1: Control group (sham operated). Group 2: Ovariectomized rats (OVX). Group 3: Ovariectomized rats (OVX)+E2. Group 4: Ovariectomized rats (OVX)+ACEI. Group 5: Ovariectomized rats (OVX)+E2+ACEI. Results: OVX rats showed a significant decrease in serum Ca 2+ and OPG levels with significant increase in serum RANKL, osteocalcin, alkaline phosphatase activity and urinary hydroxyproline levels compared to control group. Treatment with ramipril as well as E2 led to a significant improvement in bone markers levels with a significant increase in serum OPG level with a significant reduction in serum RANKL level compared to OVX group. Conclusion: Ramipril as ACEI had more significant effect on decreasing serum bone markers level than 17-β estradiol in ovariectomized rats. So, we can draw the conclusion that altering OPG/RANKL signalling may be a possible mechanism by which E2 and ACEI prevent osteoporosis.

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“…The effects of RAAS inhibitors were also reported in many studies. The mice with bilateral orchiectomy may have a significantly increased trabecular bone area after the treatment of captopril [ 38 ]. Similarly, another animal study also proved that imidapril treatment may reduce the decrease of bone density and inhibit the increase in osteoclast activation in rats with ovariectomy [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

The use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers may relate to the survival and walking ability in geriatric patients with hip fractures: a 1-year follow-up study

Chu

Wang

Chu

2023

BMC Musculoskelet Disord

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Background Many elder patients with hip fractures also suffered from hypertension. This study aims to explore the relationship between the use of ACEI or ARB and the outcomes of geriatric hip fractures. Methods All the patients were divided into four groups: non-users without hypertension, non-users with hypertension, ACEI users, and ARB users. The outcomes of patients in different groups were compared. LASSO regression and univariable Cox analysis were used for variable screening. Then Cox models and Logistics models were established to identify the relationships between the use of RAAS inhibitors and outcomes. Results ACER users (p = 0.016) and ARB users (p = 0.027) had a significantly lower survival probability than the non-users with hypertension. Non-users without hypertension, ACEI users, and ARB users may face lower 6-month and 1-year mortalities and higher 6-month and 1-year free walking rates compared with non-users with hypertension. Conclusion Patients with the use of ACEI or ARB may face a better prognosis of hip fractures.

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Inhibition on angiotensin-converting enzyme exerts beneficial effects on trabecular bone in orchidectomized mice

Abstract: The inhibition on ACE by captopril exerts beneficial effects on trabecular bone of ORX mice. The therapeutic efficacy may be attributed to the regulation of captopril on local RAS and cytokines in bone.

Cited by 9 publications

References 44 publications

Osteoprotective action of low-salt diet requires myeloid cell–derived NFAT5

Osteoprotective action of low-salt diet requires myeloid cell–derived NFAT5

Role of 17-β Estradiol and Ramipril in OPG/RANKL Pathway in a Rat Model of Post-Menopausal Osteoporosis

The use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers may relate to the survival and walking ability in geriatric patients with hip fractures: a 1-year follow-up study

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