Inhibition within the trigeminal nucleus induced by afferent inputs and its influence on stimulus coding by mechanosensitive neurones

Carmody, John; Rowe, Mark J.

doi:10.1113/jphysiol.1974.sp010749

Cited by 18 publications

(24 citation statements)

References 23 publications

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“…neurones were constructed at different vibration frequencies by plotting the response rate (impulses s-1) against vibration amplitude. These relations rise VIBRATION CODING IN GRACILE AND CUNEATE CELLS steeply at frequencies of 100-400 Hz attaining plateau levels of response over an amplitude range, or dynamic range (Carmody & Rowe, 1974;Douglas et al 1978), of less than 10-25 ,um. Although the P.c.…”

Section: Classes Of Neurones Activated By Tactile Inputs From the Foomentioning

confidence: 97%

Temporal patterning in the responses of gracile and cuneate neurones in the cat to cutaneous vibration.

Ferrington

Horniblow

Rowe

1987

The Journal of Physiology

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SUMMARY1. Recordings were made in decerebrate cats from gracile and cuneate neurones responding to vibration-induced inputs from Pacinian corpuscle (P.c.) receptors of the hind-limb and forelimb footpads. The two groups of neurones were compared, in particular for their capacities for responding to cutaneous vibration with phaselocked impulse patterns.2. In both nuclei the P.c. neurones were most sensitive to vibration in the range 80 to > 600 Hz. Stimulus-response relations were similar for the two groups, as were measures derived from these relations such as response levels, absolute thresholds and the dynamic range (defined as the vibration amplitude range over which responses were graded).

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Section: Classes Of Neurones Activated By Tactile Inputs From the Foomentioning

confidence: 97%

Temporal patterning in the responses of gracile and cuneate neurones in the cat to cutaneous vibration.

Ferrington

Horniblow

Rowe

1987

The Journal of Physiology

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“…Over the steepest linear portion, connecting at least three or four points on the curve, the slope ranged from 4-6 to 37 0 impulses/I00 ,tm of indentation (n = 10) with a mean of 15 7 impulses/t00 /m. The dynamic range, defined as the range of stimulus indentation over which the unit exhibits a graded responsiveness (Carmody & Rowe, 1974;Bystrzycka et al 1977) was often < 0 5-0-7 mm (Fig. 1C).…”

Section: Neonatal Tactile Afferents Slowly Adapting Tactile Afferent mentioning

confidence: 99%

“…Fibres selected for study had tactile receptive fields on the glabrous skin of the forelimb foot pads. Precise and reproducible mechanical stimuli were derived from a servo-controlled mechanical stimulator used in previous studies from this laboratory (Darian-Smith, Rowe & Sessle, 1968;Carmody & Rowe, 1974;Bystrzycka, Nail & Rowe, 1977;Ferrington, Nail & Rowe, 1977;Douglas, Ferrington & Rowe, 1978;Bennett, Ferrington & Rowe, 1980;. Stimuli were applied to the point of maximum sensitivity within the receptive field of the fibre using a circular probe, 1 mm in diameter for kitten studies and 2 mm for the adults.…”

Section: Neonatal Tactile Afferents 337mentioning

confidence: 99%

Functional capacities of tactile afferent fibres in neonatal kittens

Ferrington

Rowe

1980

The Journal of Physiology

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SUMMARY1. Responses were recorded from individual tactile afferent fibres isolated by microdissection from the median nerve of pentobarbitone-anaesthetized neonatal kittens (1-5 days post-natal age). Experiments were also conducted on adult cats to permit precise comparisons between neonatal and adult fibres.2. Neonatal fibres with receptive fields on the glabrous skin of the foot pads were classified into two broad groups, a slowly adapting class (40 %) which responded throughout a 1 see period of steady indentation and a rapidly adapting or dynamically sensitive class comprising 60 % of units. Fibres in these two groups had overlapping conduction velocities in the range 4-3 to 7-5 m/sec and were believed to be the developing Group II afferents of the adult. 3. Neonatal slowly adapting fibres qualitatively resembled their adult counterparts. They displayed graded stimulus-response relations which, over the steepest segment of the curves, had mean slopes of 15-7 impulses/100um of indentation. Plateau levels of response were often reached at amplitudes of skin indentation of < 0 5-0 7 mm.4. Dynamically sensitive fibres with receptive fields on the glabrous skin were studied using sinusoidal cutaneous vibration which in the adult enables them to be divided into two distinct classes. However, in the neonate, they formed a continuum whether criteria of sensitivity or responsiveness were used.5. In response to vibration neonatal fibres differed from adult ones according to the following quantitative indices: (i) sensitivity as measured by both absolute thresholds and thresholds for a 1:1 pattern of response, both of which were higher in the neonate than in the adult at all frequencies > 50 Hz and differed by an order of magnitude at frequencies > 200 Hz; (ii) responsiveness based on the mean impulse rate evoked at a fixed amplitude of cutaneous vibration; (iii) band width of vibratory sensitivity which in the neonate was confined to approximately 5-300 Hz whereas in the two classes of adult units it covered the range 5-800 Hz; (iv) capacity for coding information about vibration frequency. Impulse activity of neonatal fibres was less tightly phase-locked to the vibratory stimulus and showed a poorer reflection of the periodic nature of the vibratory stimulus than impulse patterns of adult units.6. The results reveal that tactile receptors and afferent fibres in the neonate are functionally immature. Their restricted coding capacities suggest that peripheral tactile sensory mechanisms impose limits on the ability of the new-born animal to derive information about its tactile environment.

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“…Low-threshold mechanoreceptive fibers maintain a somatotopic arrangement up to the cuneatus and gracilis nuclei (Uddenberg, 1966;Whitsel et al, 1969), where they synapse onto submodality-specific neurons segregated rostrocaudally (Kruger et al, 1961;Perl et al, 1962;Gordon and Jukes, 1964;Rosén, 1969a;Carmody and Rowe, 1974;Millar and Basbaum, 1975;Bystrzycka et al, 1977;Douglas et al, 1978;Golovchinsky, 1980;Dykes et al, 1982;Berkley et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

Processing Afferent Proprioceptive Information at the Main Cuneate Nucleus of Anesthetized Cats

Leiras¹,

Velo²,

Martín-Cora³

et al. 2010

J. Neurosci.

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Medial lemniscal activity decreases before and during movement, suggesting prethalamic modulation, but the underlying mechanisms are largely unknown. Here we studied the mechanisms underlying proprioceptive transmission at the midventral cuneate nucleus (mvCN) of anesthetized cats using standard extracellular recordings combined with electrical stimulation and microiontophoresis. Dual simultaneous recordings from mvCN and rostroventral cuneate (rvCN) proprioceptive neurons demonstrated that microstimulation through the rvCN recording electrode induced dual effects on mvCN projection cells: potentiation when both neurons had excitatory receptive fields in muscles acting at the same joint, and inhibition when rvCN and mvCN cells had receptive fields located in different joints. GABA and/or glycine consistently abolished mvCN spontaneous and sensory-evoked activity, an effect reversed by bicuculline and strychnine, respectively; and immunohistochemistry data revealed that cells possessing strychnine-sensitive glycine receptors were uniformly distributed throughout the cuneate nucleus. It was also found that proprioceptive mvCN projection cells sent ipsilateral collaterals to the nucleus reticularis gigantocellularis and the mesencephalic locomotor region, and had slower antidromic conduction speeds than cutaneous fibers from the more dorsally located cluster region.The data suggest that (1) the rvCN-mvCM network is functionally related to joints rather than to single muscles producing an overall potentiation of proprioceptive feedback from a moving forelimb joint while inhibiting, through GABAergic and glycinergic interneurons, deep muscular feedback from other forelimb joints; and (2) mvCN projection cells collateralizing to or through the ipsilateral reticular formation allow for bilateral spreading of ascending proprioceptive feedback information.

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Inhibition within the trigeminal nucleus induced by afferent inputs and its influence on stimulus coding by mechanosensitive neurones

Cited by 18 publications

References 23 publications

Temporal patterning in the responses of gracile and cuneate neurones in the cat to cutaneous vibration.

Temporal patterning in the responses of gracile and cuneate neurones in the cat to cutaneous vibration.

Functional capacities of tactile afferent fibres in neonatal kittens

Processing Afferent Proprioceptive Information at the Main Cuneate Nucleus of Anesthetized Cats

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