Inhibitions of mast cell-derived histamine release by different Flos Magnoliae species in rat peritoneal mast cells

Shen, Yingjun; Pang, E. C. K.; Xue, Charlie Changli; Zhao, Zhongzhen; Lin, Jaung‐Geng; Li, Chun Guang

doi:10.1016/j.phymed.2008.04.012

Cited by 53 publications

(33 citation statements)

References 6 publications

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“…Various essential oils, lignans, neolignans and sesquiterpenes, e.g., magnolin, epimagnolin A, fargesin, dimethylpinoresinol, dimethylliroresinol, aschantin, and magnone A and B have been found from this crude drug (Chae et al, 1998;Jung et al, 1998;Ahn et al, 2001;Lee et al, 2002;Zhao et al, 2007;Shen et al, 2008;Baek et al, 2009;Kim et al, 2009a). Magnolin, 1-(3,4-dimethoxy-phenyl)-4-(3,4,5-trimethoxyphenyl)-tetrahydro-furo [3,4-c]furan, is a major pharmacologically active ingredient which possesses antiinflammatory and antihistamininic activities and inhibits the expression of the cell adhesion molecules ICAM-1 and VCAM-1 (Chae et al, 1998;Ahn et al, 2001;Lee et al, 2002;Shen et al, 2008;Kim et al, 2009a).…”

Section: Introductionmentioning

confidence: 93%

Pharmacokinetics of magnolin in rats

et al. 2010

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This study was first conducted to characterize the intravenous and oral pharmacokinetics of magnolin, a major pharmacologically active ingredient of Magnolia fargesii, at various doses in rats. Magnolin was administered to rats by intravenous injection (0.5, 1 and 2 mg/kg doses) and oral administration (1, 2 and 4 mg/kg doses), and serial plasma and urine samples were harvested. Magnolin concentrations were determined by a validated LC/MS/MS assay. After both intravenous and oral administration, the AUCs were linearly increased as the dose increased. Other pharmacokinetic parameters of magnolin (except the V ( ss ) after the intravenous administration) were also independent of the doses. The extent of absolute oral bioavailability ranged from 54.3-76.4% for the oral doses examined. Magnolin was considerably bound to rat plasma proteins and the binding value was constant (71.3-80.5%) over a concentration ranging from 500 to 10000 ng/mL. The pharmacokinetic parameters of magnolin were dose-independent after both intravenous and oral administration. When given orally, magnolin was rapidly absorbed.

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Section: Introductionmentioning

confidence: 93%

Pharmacokinetics of magnolin in rats

et al. 2010

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“…Various biologically active compounds such as eudesmin, magnolin, epimagnoli, neolignans, lignans, phenyl propanoids, sesquiterpenes, and alkaloids have been also isolated from Magnolia spp. (Kelm & Nair, 2000;Seo, 2010;Shen et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and tyrosinase inhibitory activities of methanol extracts from Magnolia denudata and Magnolia denudata var. purpurascens flowers

Seo

Yuk

et al. 2012

Food Research International

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“…Extracts and dried formulations from Magnolia can inhibit compound 48/80-induced rat peritoneal mast cell degranulation [50] suggesting that these effects are mediated by direct inhibition of mast cells. However, compound 48/80 is a non-specific agonist of G protein signaling pathways that are only partially related to IgE/Fc RI activation and therefore it remains to be determined whether Magnolia can also inhibit allergen induced mast cell activation.…”

Section: Pinus Pinastermentioning

confidence: 99%

The Potential of Natural Products as Effective Treatments for Allergic Inflammation: Implications for Allergic Rhinitis

Kulka¹

2009

CTMC

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Abstract:The impact of natural products on human health has been enormous, and the study of natural products continues to influence research in the fields of chemistry, biology, and ecology. Historically, the majority of our medicines originate from natural products and their synthetic derivatives, many of which have taught us valuable lessons about biology. While advances in synthetic and combinatorial chemistry have given rise to notable successes in the development of new drugs, the perceived value of natural products in the treatment of allergic disease has yet to be fully explored. The immune system is a highly complex, intricately regulated group of cells whose integrated function is essential to health. Cells of the immune system may interact in a cell-cell manner and may also respond to intercellular messages including hormones, cytokines, and effector molecules produced by various cells. These effector molecules include histamine, kinins, leukotrienes, prostaglandins, and serotonin. The immune system can be modified by diet, pharmacologic agents, environmental pollutants, and naturally occurring food chemicals, such as vitamins and flavonoids. Allergic inflammation is mediated by several types of immune cells all of which can be effected by these naturally occurring bioactive compounds but this review will focus on mast cells and their mediators since these cells are the focal point of allergic reactions such as allergic rhinitis. The molecular mechanisms and scientific validity of some herbal remedies currently used clinically in the treatment of allergic rhinitis will be explored.

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Inhibitions of mast cell-derived histamine release by different Flos Magnoliae species in rat peritoneal mast cells

Cited by 53 publications

References 6 publications

Pharmacokinetics of magnolin in rats

Pharmacokinetics of magnolin in rats

Antioxidant and tyrosinase inhibitory activities of methanol extracts from Magnolia denudata and Magnolia denudata var. purpurascens flowers

The Potential of Natural Products as Effective Treatments for Allergic Inflammation: Implications for Allergic Rhinitis

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