1994
DOI: 10.1203/00006450-199401000-00003
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Inhibitor of Nitric Oxide Synthesis Reduces Hypoxic-Ischemic Brain Damage in the Neonatal Rat

Abstract: ABSTRACI'. We evaluated the neuroprotective effect of lium in the conversion of L-arginine to L-citrulline by the enzyme the nitric oxide synthesis inhibitor, NC-nitro-L-arginine in NO synthase ( 9 , whose activity has also been reported in forea neonatal hypoxic-ischemic rat model. Unilateral hypoxic-brain homogenates (6). NMDA stimulates NO synthesis (7), and ischemic iqjury was produced in the brain of 7-dsld rats NO mediates glutamate neurotoxicity in vitro (8). NOARG, an using a combition of a common caro… Show more

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Cited by 150 publications
(65 citation statements)
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“…Inhibiting NOS II by specific inhibitor in the newborn rat model of HI also reduces injury (2). Even nonselective NOS inhibitors have shown efficacy in the rat pup (1,5). Agmatine is more than an order of magnitude more potent with NOS I and NOS II than with NOS III (23).…”
Section: Discussionmentioning
confidence: 99%
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“…Inhibiting NOS II by specific inhibitor in the newborn rat model of HI also reduces injury (2). Even nonselective NOS inhibitors have shown efficacy in the rat pup (1,5). Agmatine is more than an order of magnitude more potent with NOS I and NOS II than with NOS III (23).…”
Section: Discussionmentioning
confidence: 99%
“…Inhibitors of nitric oxide synthase (NOS) and antagonists of N-methyl-D-aspartate (NMDA) glutamate receptors are neuroprotective in hypoxia-ischemic (HI) brain injury (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). Formed from the decarboxylation of L-arginine by the enzyme arginine decarboxylase (11)(12)(13)(14), agmatine is a 4-carbon elongated relative of the synthetic neuroprotective agent, aminoguanidine (12).…”
mentioning
confidence: 99%
“…5 Therefore, the therapeutic value of NO synthase inhibitors, among many other agents used to ameliorate the course of HIE, is currently under investigation in experimental animals. 6 Erythropoietin is a cytokine that originally was identified for its role in erythropoiesis and more recently was shown to be produced in the central nervous system. 7 The provision of exogenous erythropoietin has been shown to inhibit metabolic events that occur during HIE.…”
mentioning
confidence: 99%
“…[1][2][3] Given the great plasticity of the developing brain, functional measures of injury are likely to be more clinically relevant. Although neurofunctional deficit after an HI insult in rats has been reported, 4,5 in mice neurofunctional studies have been applied in an adult mouse stroke model and were limited to assessment of short-term (24 hours to 4 days after stroke) neurobehavioral recovery.…”
mentioning
confidence: 99%