Inhibitoren des Endocannabinoid‐Abbaus: potenzielle Therapeutika neurologischer Störungen

Wendeler, Michaela; Kolter, Thomas

doi:10.1002/ange.200301641

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Inhibitor Discovery By Abpp1

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2003

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“…The FAAH-selective inhibitors identified in this study may represent attractive lead compounds for the development of therapeutic agents for the treatment of pain and other neurological disorders. [41,42] …”

Section: Inhibitor Discovery By Abppmentioning

confidence: 98%

Chemical Strategies for Activity‐Based Proteomics

2003

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The assignment of molecular and cellular functions to the numerous protein products encoded by prokaryotic and eukaryotic genomes presents a major challenge for the field of proteomics. To address this problem, chemical approaches have been introduced that utilize small-molecule probes to profile dynamics in enzyme activity in complex proteomes. These strategies for activity-based protein profiling enable both the discovery and functional analysis of enzymes associated with human disease.

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Section: Inhibitor Discovery By Abppmentioning

confidence: 98%