Inhibitors of trypsin-like proteolytic enzymes as substances preventing the development of secondary necrosis in burn wounds

Muzykant, L. I.; Zaets, T. L.; Dolgina, M I; Kotkina, T. I.; Nosova, I. M.

doi:10.1007/bf00805877

Cited by 1 publication

(2 citation statements)

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“…[287] Two other abstracts from 1977 and 1985 claim positive outcomes for applying a protease inhibitor to treat burn wounds. [288,289] The question is whether there is any benefit in controlling the protease level. To be able to answer this question through an evidence-based approach, the protease level has to be modulated directly, and its change should not be secondary to any other factor, for example, inflammation suppression.…”

Section: On the Usefulness Of Controlling Protease Levelmentioning

confidence: 99%

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Approaches to Control and Monitor Protease Levels in Chronic Wounds

Kolahreez,

Ghasemi‐Mobarakeh,

Liebner

et al. 2024

Advanced Therapeutics

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Some wounds do not follow the typical healing trajectory and show very little, if any, progress. They dreadfully threaten the patients' quality of life and may even lead to limb amputation and death. Several interrelated systemic and local factors may cause a delay in wound healing. The microenvironment of these wounds could be different from wounds that heal spontaneously or with standard treatment. As discussed in the present work, proteases’ levels or activity could be elevated in some cases of chronic ulcers; infection could aggravate the situation. A detailed overview of the proteases’ effect on wound healing is presented in this paper. Assuming untimely or irregularly excessive proteolytic activity plays a pathological role, some researchers targeted attenuation of protease level as a strategy to promote healing. This could be done via different approaches, including physical removal, inhibiting their activity, and controlling their expression directly through gene silencing or indirectly, for instance, by resolving infection. Apart from targeting protease modulation as a therapeutic strategy, many studies have examined the protease state to gain insights into the underlying mechanisms by which a remedy, dressing, or specific therapy has affected the healing process. This article aims to provide an overview of the studies in these two categories. Of course, various proteases are involved in the healing process, but in each study, usually, only one or some of them were investigated; matrix metalloproteinase‐2 (MMP‐2), MMP‐9, and human neutrophil elastase (HNE) are among them. Furthermore, in some cases, cumulative proteolytic activity has been evaluated in terms of gelatinolytic, collagenolytic, or caseinolytic activity, which is also absolutely beneficial. Some research groups have considered the potential of proteases as a diagnostic or prognostic biomarker and have tried to develop some sensors or indicators; this topic has also been covered in the present work.This article is protected by copyright. All rights reserved

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Section: On the Usefulness Of Controlling Protease Levelmentioning

confidence: 99%

“…[ 287 ] Two other abstracts from 1977 and 1985 claim positive outcomes for applying a protease inhibitor to treat burn wounds. [ 288,289 ]…”

Section: On the Usefulness Of Controlling Protease Levelmentioning

confidence: 99%