Inhibitory Action of the Ginseng Total Saponin on the Nalbuphine-Induced Tolerance and Withdrawal Syndrome

Background: Cancer is known to be the second significant cause of death worldwide. Chemotherapeutic agents such as platinum-based compounds are frequently used single-handedly or accompanied with additional chemotherapies to treat cancer patients. Chemotherapy-inducedperipheral painful neuropathy is seen in around 40% of patient who are treated with platinum-based compounds including cisplatin. This not only decreases quality of life of patients but also patients’ compliance to cisplatin. Objectives: Nalbuphine, an opioid, is frequently used to treat acute and chronic pain coupled with cisplatin in cancer patients. However, long term use of nalbuphine induces tolerance to its analgesic effects. We employed the same strategy to induce tolerance in mice. Methods: Here, we investigated analgesic effects of 2-[(pyrrolidin-1-yl) methyl]-1H-benzimidazole (BNZ), a benzimidazole derivative, on nalbuphine-induced tolerance during cisplatin-induced neuropathic pain using hot plate test, tail flick tests andvon Frey filament in mouse models. Furthermore, we investigated the effects of BNZ on the expression of tumor necrosis factor alpha (TNF-α) in spinal cord. Results: The results showed that BNZ reduced tolerance to analgesic effects of nalbuphine and TNF-α expression in mice. Conclusion: BNZ could be potential drug candidate for the management of nalbuphine-induced tolerance in cisplatin-induced neuropathicpain.

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Benzimidazole Derivative Ameliorates Opioid-Mediated Tolerance during Anticancer- Induced Neuropathic Pain in Mice

Akhtar

Abbas

Naeem

et al. 2021

ACAMC

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Inhibitory Action of the Ginseng Total Saponin on the Nalbuphine-Induced Tolerance and Withdrawal Syndrome

Cited by 1 publication

References 13 publications

Benzimidazole Derivative Ameliorates Opioid-Mediated Tolerance during Anticancer- Induced Neuropathic Pain in Mice

Benzimidazole Derivative Ameliorates Opioid-Mediated Tolerance during Anticancer- Induced Neuropathic Pain in Mice

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