Inhibitory action of water soluble fraction of Terminalia chebula on systemic and local anaphylaxis

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

“…All six traditional rasayana plants were able to aid the animals against a variety of different stressors working in different ways [77] . Besides, animal studies show that when extract of T. chebula was administered following induction of anaphylactic shock, the serum histamine levels were reduced, indicating its strong antianaphylactic action [78] . Water soluble fraction of T. chebula had a significant increasing effect on anti-dinitrophenyl IgE-induced tumor necrosis factor-alpha production from rat peritoneal mast cells indicating its strong antianaphylactic action [78] .…”

“…F rom the literature it has been noted that T. chebula exhibited significant hepatoprotective [36][37][38] , cardioprotective [39,40] , antimutagenic/anticarcinogenic [31-3 3 ] , c y t o p r o t e c t i v e [ 4 1 -4 4 ] , a n t i o x i d a n t [ 2 4 -3 0 ] a n d adaptogenic [77,78] effects. Aqueous, ethanol, and ethyl acetate extracts of T. chebula fruits also demonstrated no cellular toxicity on sheep erythrocytes as well as acute oral toxic effects on rats at recommended and higher doses [48,91,92] .…”

Determination of hydrolyzable tannins in the fruit of Terminalia chebula Retz. by high‐performance liquid chromatography and capillary electrophoresis

“…A number of biological activities in water or alcoholic extracts of Chebulae Fructus have been reported. These include anticancer [7 -9], antioxidation [10,11], antimicrobial [12,13], and immunomodulation [14] activities, inhibition of anaphylaxis [15], and the inhibition of nitric oxide synthesis [16]. According to the classical definition previously proposed by Freudenberg [17], plant tannins are divided into hydrolyzable tannins and flavonoid-derived condensed tannins.…”

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“…Terminalia chebula Retz was found to possess antianaphylactic activities as it reduced the serum histamine levels in animals after induction of anaphylactic shock 11 . Terminalia chebula Retz resulted in the reduction of peroxidation of membrane lipids in the mice liver as well as decrease in radiation induced damage to DNA in mice who were given aqueous extract of the fruit prior to whole body irradiation 12 .…”