1993
DOI: 10.1111/j.1476-5381.1993.tb13815.x
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Inhibitory actions of ZENECA ZD7288 on whole‐cell hyperpolarization activated inward current (If) in guinea‐pig dissociated sinoatrial node cells

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Cited by 295 publications
(245 citation statements)
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“…A 15 min exposure to ZD7288 (10 pmM-100 gM) produced a concentration-dependent inhibition of IIR in the rat detrusor and at the highest concentration, the current was virtually abolished (Figure 6a-c). As reported in cells of the sino-atrial node (BoSmith et al, 1993), the time-course of inhibition of the detrusor inward current was slow. With a longer incubation period of 30 min, ZD7288 (1 gM) also produced a significant inhibition of AIR (n = 3, data not shown).…”
Section: Zd7288mentioning
confidence: 70%
See 1 more Smart Citation
“…A 15 min exposure to ZD7288 (10 pmM-100 gM) produced a concentration-dependent inhibition of IIR in the rat detrusor and at the highest concentration, the current was virtually abolished (Figure 6a-c). As reported in cells of the sino-atrial node (BoSmith et al, 1993), the time-course of inhibition of the detrusor inward current was slow. With a longer incubation period of 30 min, ZD7288 (1 gM) also produced a significant inhibition of AIR (n = 3, data not shown).…”
Section: Zd7288mentioning
confidence: 70%
“…The inhibition of Ih in cells of the guinea-pig sinoatrial node and the resulting bradycardia has been described by BoSmith et al (1993). A 15 min exposure to ZD7288 (10 pmM-100 gM) produced a concentration-dependent inhibition of IIR in the rat detrusor and at the highest concentration, the current was virtually abolished (Figure 6a-c).…”
Section: Zd7288mentioning
confidence: 89%
“…Current density of I h was significantly greater in neurons from neonatal as compared to adult rats; however, the reversal potential and activation parameters were unchanged (see Table 1). I h was sensitive to changes in external Na + and K + concentrations and was irreversibly blocked by 10-100 μM ZD 7288, a selective inhibitor of I h (Bosmith et al, 1993). Fig.…”
Section: Hyperpolarization-activated Currents I H and I K(ir)mentioning
confidence: 86%
“…In spite of many in vitro reports on Ih channels (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) as well as in vivo studies on the pacemaking function of Ih (25)(26)(27)(28), any contributions of Ih to epileptic activity are unknown in vivo, except for the one that showed the long-lasting enhancement of the widely expressed intrinsic Ih that converts the potentiated synaptic inhibition to hyperexcitability in the hippocampus of rats that had febrile seizures (29).…”
mentioning
confidence: 99%