Inhibitory activities of phloroglucinol-chitosan nanoparticles on mono- and dual-species biofilms of Candida albicans and bacteria

Khan, F. Nawaz; Oh, DoKyung; Chandika, Pathum; Jo, Du-Min; Bamunarachchi, Nilushi Indika; Jung, Won‐Kyo; Kim, Young‐Mog

doi:10.1016/j.colsurfb.2021.112307

Cited by 23 publications

(24 citation statements)

References 59 publications

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“…In recent trends, nanotechnology, particularly nanocarriers and nanoformulation, are evolving to overcome the limits associated with natural products and allow targeted and controlled drug delivery. To treat microbial infections, the phlorotannin must be loaded onto the nanocarrier (metallic or nonmetallic) in such a way that the nanocarriers are biocompatible and have inherent antimicrobial capabilities allowing for the synergistic killing of the microbial pathogens [143].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Seaweed-Derived Phlorotannins: A Review of Multiple Biological Roles and Action Mechanisms

et al. 2022

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Phlorotannins are a group of phenolic secondary metabolites isolated from a variety of brown algal species belonging to the Fucaceae, Sargassaceae, and Alariaceae families. The isolation of phlorotannins from various algal species has received a lot of interest owing to the fact that they have a range of biological features and are very biocompatible in their applications. Phlorotannins have a wide range of therapeutic biological actions, including antimicrobial, antidiabetic, antioxidant, anticancer, anti-inflammatory, anti-adipogenesis, and numerous other biomedical applications. The current review has extensively addressed the application of phlorotannins, which have been extensively investigated for the above-mentioned biological action and the underlying mechanism of action. Furthermore, the current review offers many ways to use phlorotannins to avoid certain downsides, such as low stability. This review article will assist the scientific community in investigating the greater biological significance of phlorotannins and developing innovative techniques for treating both infectious and non-infectious diseases in humans.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Seaweed-Derived Phlorotannins: A Review of Multiple Biological Roles and Action Mechanisms

et al. 2022

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“…Phloroglucinol encapsulated in chitosan nanoparticles by ionic gel technology is more effective against bacteria such as Staphylococcus aureus than pure phloroglucinol [ 18 ]. The addition of the polyphenol phloroglucinol to chitosan hydrogels reduced the growth of E. coli and also improved the antioxidant activity of the hydrogels [ 19 ]. Several studies have discussed the promising future of phloroglucinol and its derivatives in conjugation, nanoformulations, antibiotic combinations and encapsulation in antibacterial applications [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Phloroglucinol Derivative Carbomer Hydrogel Accelerates MRSA-Infected Wounds’ Healing

Huang

Yang

Zhang

et al. 2022

IJMS

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Globally, wound infection is considered to be one of the major healthcare problems, with bacterial infections being the most critical threat, leading to poor and delayed wound healing, and even death. As a superbug, methicillin-resistant Staphylococcus aureus (MRSA) causes a profound hazard to public health safety, prompting us to search for alternative treatment approaches. Herein, the MTT test and Hoechst/propidium iodide (PI) staining demonstrated that PD was slightly less toxic to human fibroblasts including Human keratinocytes (HaCaT) cell line than Silver sulfadiazine (SSD), and Vancomycin (Van). In the MRSA-infected wound model, PD hydrogel (1%, 2.5%) was applied with for 14 days. The wound healing of PD hydrogel groups was superior to the SSD, Van, and control groups. Remarkably, the experimental results showed that PD reduced the number of skin bacteria, reduced inflammation, and upregulated the expression of PCNA (keratinocyte proliferation marker) and CD31 (angiogenesis manufacturer) at the wound site by histology (including hematoxylin–eosin (HE) staining, Masson staining) and immunohistochemistry. Additionally, no toxicity, hemocompatibility or histopathological changes to organs were observed. Altogether, these results suggested the potential of PD hydrogel as a safe, effective, and low toxicity hydrogel for the future clinical treatment of MRSA-infected wounds.

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“…Phloroglucinol-encapsulated chitosan nanoparticles showed antibiofilm action against single-species biofilms, such as K. pneumoniae , S. aureus , S. mutans , and C. albicans, and mixed-species biofilms, such as C. albicans - S. aureus/K. pneumoniae / S. mutans [ 139 ]. Gold and zinc oxide nanoparticles produced with phloroglucinol showed significant antibacterial action against P. aeruginosa [ 140 ].…”

Section: Marine Bioinspired Nps For Treating Non-infectious Diseasesmentioning

confidence: 99%

“…The PG-CSNPs exhibit antibiofilm properties towards single- and mixed-species biofilms of C. albicans - S. aureus / S. mutans / K. penumoniae . Reprinted with permission from reference [ 139 ], and ( D ) Synthesis of metal (AuNPs) and metal oxide (ZnONPs) nanoparticles using phloroglucinol. The synthesized PG-AuNPs and PG-ZnONPs showed antibiofilm and antivirulence properties towards P. aeruginosa .…”

Section: Figurementioning

confidence: 99%

Marine-Bioinspired Nanoparticles as Potential Drugs for Multiple Biological Roles

et al. 2022

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The increased interest in nanomedicine and its applicability for a wide range of biological functions demands the search for raw materials to create nanomaterials. Recent trends have focused on the use of green chemistry to synthesize metal and metal-oxide nanoparticles. Bioactive chemicals have been found in a variety of marine organisms, including invertebrates, marine mammals, fish, algae, plankton, fungi, and bacteria. These marine-derived active chemicals have been widely used for various biological properties. Marine-derived materials, either whole extracts or pure components, are employed in the synthesis of nanoparticles due to their ease of availability, low cost of production, biocompatibility, and low cytotoxicity toward eukaryotic cells. These marine-derived nanomaterials have been employed to treat infectious diseases caused by bacteria, fungi, and viruses as well as treat non-infectious diseases, such as tumors, cancer, inflammatory responses, and diabetes, and support wound healing. Furthermore, several polymeric materials derived from the marine, such as chitosan and alginate, are exploited as nanocarriers in drug delivery. Moreover, a variety of pure bioactive compounds have been loaded onto polymeric nanocarriers and employed to treat infectious and non-infectious diseases. The current review is focused on a thorough overview of nanoparticle synthesis and its biological applications made from their entire extracts or pure chemicals derived from marine sources.

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Inhibitory activities of phloroglucinol-chitosan nanoparticles on mono- and dual-species biofilms of Candida albicans and bacteria

Cited by 23 publications

References 59 publications

Seaweed-Derived Phlorotannins: A Review of Multiple Biological Roles and Action Mechanisms

Seaweed-Derived Phlorotannins: A Review of Multiple Biological Roles and Action Mechanisms

Phloroglucinol Derivative Carbomer Hydrogel Accelerates MRSA-Infected Wounds’ Healing

Marine-Bioinspired Nanoparticles as Potential Drugs for Multiple Biological Roles

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