Inhibitory activity and action mechanism of coumoxystrobin against Phytophthora litchii, which causes litchi fruit downy blight

Zhang, Jing; Zhu, Fadi; Gu, Mengxuan; Ye, Huo-Chun; Gu, Liushuang; Zhan, Ligang; Liu, Changling; Yan, Chao; Feng, Gang

doi:10.1016/j.postharvbio.2021.111675

Cited by 10 publications

(4 citation statements)

References 23 publications

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“…Benzopyran serves as a natural scaffold containing seven modifiable sites, providing scope for increased diversity and selectivity of structural modification. The chemical structures and action mechanism of some pesticides, veterinary drugs or active compounds containing a benzopyran fragment are shown in Figure and Table , − respectively.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances and Outlook of Benzopyran Derivatives in the Discovery of Agricultural Chemicals

Liu,

Zhang,

Zou

et al. 2024

J. Agric. Food Chem.

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Scaffold structures, new mechanisms of action, and targets present enormous challenges in the discovery of novel pesticides. The discovery of new scaffolds is the basis for the continuous development of modern agrochemicals. Identification of a good scaffold such as triazole, carbamate, methoxy acrylate, pyrazolamide, pyrido-pyrimidinone mesoionic, and bisamide often leads to the development of a new series of pesticides. In addition, pesticides with the same target, including the inhibitors of succinate dehydrogenase (SDH), oxysterol-binding-protein, and p-hydroxyphenyl pyruvate dioxygenase (HPPD), may have the same or similar scaffold structure. Recent years have witnessed significant progress in the discovery of new pesticides using natural products as scaffolds or bridges. In recent years, there have been increasing reports on the application of natural benzopyran compounds in the discovery of new pesticides, especially osthole and coumarin. A systematic and comprehensive review of benzopyran active compounds in the discovery of new agricultural chemicals is helpful to promote the discussion and development of benzopyran active compounds. Therefore, this work systematically reviewed the research and application of benzopyran derivatives in the discovery of agricultural chemicals, summarized the antiviral, herbicidal, antibacterial, fungicidal, insecticidal, nematicidal and acaricidal activities of benzopyran active compounds, and discussed the structural−activity relationship and mechanism of action. In addition, some active fragments were recommended to further optimize the chemical structure of benzopyran active compounds based on reference information.

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Section: Introductionmentioning

confidence: 99%

Recent Advances and Outlook of Benzopyran Derivatives in the Discovery of Agricultural Chemicals

Liu,

Zhang,

Zou

et al. 2024

J. Agric. Food Chem.

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“…3 Postharvest disease control for litchi fruits primarily relies on treatments with sulfur dioxide (SO 2 ) and synthetic chemicals such as azoxystrobin, metalaxyl, and dimethomorph (DMM). 4 Discovering alternative treatments for postharvest diseases is an ongoing effort because of pathogen resistance and concerns regarding the impacts of current fungicides on human and environmental health. Microorganisms are an attractive resource for biological pesticide discovery due to the many bioactive secondary metabolites they produce with antifungal, antibacterial, and nematocidal properties.…”

Section: Introductionmentioning

confidence: 99%

“…Postharvest disease control for litchi fruits primarily relies on treatments with sulfur dioxide (SO 2 ) and synthetic chemicals such as azoxystrobin, metalaxyl, and dimethomorph (DMM) . Discovering alternative treatments for postharvest diseases is an ongoing effort because of pathogen resistance and concerns regarding the impacts of current fungicides on human and environmental health.…”

Section: Introductionmentioning

confidence: 99%

6-Pentyl-2H-pyran-2-one from Trichoderma erinaceum Is Fungicidal against Litchi Downy Blight Pathogen Peronophythora litchii and Preservation of Litchi

Xing,

Zhao,

Zhang

et al. 2023

J. Agric. Food Chem.

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“…As a commercial coumarin fungicide, Osthole has a good inhibitory effect on Fusarium graminearum and Phytophthora capsici and has a good inhibitory effect on melon powdery mildew [ 11 ]. Coumoxystrobin containing a coumarin skeleton shows broad-spectrum fungicidal activity against many plant diseases and has been observed in field trials against cucumber downy mildew with a good inhibitory effect [ 12 ] ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

Novel Coumarin 7-Carboxamide/Sulfonamide Derivatives as Potential Fungicidal Agents: Design, Synthesis, and Biological Evaluation

et al. 2022

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Coumarin compounds have a variety of biological activities such as anti-tumor, anti-coagulation, anti-HIV, anti-fungal, and insecticidal. Amide and sulfonamide compounds have been used as fungicides for half a century, and dozens of varieties have been developed so far. This study focused on the introduction of carboxamide and sulfonamide moieties in a coumarin core to discover novel derivatives. Based on this strategy, we synthesized two series of novel carboxamide and sulfonamide substituted coumarin derivatives, and their fungicidal activity was also investigated. Some designed compounds possessed potential activities against six phytopathogenic fungi in the primary assays, highlighted by compound 6r. Compound 6r exhibited stronger fungicidal activity against Botrytis cinerea (EC50 = 20.52 µg/mL) and will be the lead structure for further study.

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Inhibitory activity and action mechanism of coumoxystrobin against Phytophthora litchii, which causes litchi fruit downy blight

Cited by 10 publications

References 23 publications

Recent Advances and Outlook of Benzopyran Derivatives in the Discovery of Agricultural Chemicals

Recent Advances and Outlook of Benzopyran Derivatives in the Discovery of Agricultural Chemicals

6-Pentyl-2H-pyran-2-one from Trichoderma erinaceum Is Fungicidal against Litchi Downy Blight Pathogen Peronophythora litchii and Preservation of Litchi

Novel Coumarin 7-Carboxamide/Sulfonamide Derivatives as Potential Fungicidal Agents: Design, Synthesis, and Biological Evaluation

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