Inhibitory Activity of Antibacterial Mouthwashes and Antiseptic Substances against Neisseria gonorrhoeae

Williams, Eloise; Zhang, Bowen; Chow, Eric P F; Chea, Socheata; Phillips, Tiffany R; Maddaford, Kate; Krysiak, Marcelina; Nong, Yi; Stefanatos, Helen; Pasricha, Shivani; Fairley, Christopher K; Williamson, Deborah A.

doi:10.1128/aac.00042-22

Antimicrob Agents Chemother

2022

DOI: 10.1128/aac.00042-22

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Inhibitory Activity of Antibacterial Mouthwashes and Antiseptic Substances against Neisseria gonorrhoeae

Eloise Williams

Bowen Zhang

Eric P F Chow

et al.

Abstract: Improved treatment and prevention strategies, such as antimicrobial mouthwashes, may be important for addressing the public health threat of antimicrobial-resistant Neisseria gonorrhoeae . Here, we describe the activity of seven common antibacterial mouthwashes and antiseptics against N. gonorrhoeae isolates, incorporating the use of a human saliva test matrix.

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2024

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Antimicrobial resistance determinants in the oropharyngeal microbiome of ‘men having sex with men’ attending an sexually transmitted infection clinic

Djusse,

Gaspari,

Morselli

et al. 2024

Int J STD AIDS

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Background ‘Men having sex with men’ (MSM) represent a key population with a significant prevalence of pharyngeal Neisseria gonorrhoeae (NG) infections and a high rate of antimicrobial resistance genes in the pharyngeal microbiome. As NG can acquire antibiotic resistance genes from other commensal oropharyngeal bacteria, monitoring the prevalence of these resistance determinants is critical to curtail the spread of NG-resistant strains. Purpose and Research Design Here, we assessed the distribution of five resistance genes ( pen (A), mtr (R), gyr (A), par (C), msr (D)) in the oropharynx of 164 MSM, attending an Outpatient clinic for STI screening. Results The most frequently detected resistance gene was msr (D) (88.4%), followed by gyr (A) (67.1%). The distribution of resistance genes was not influenced by pharyngeal gonorrhea nor by the HIV status, whereas a younger age was associated with mtr (R) presence ( p = .008). Subjects using mouthwash exhibited significantly lower levels of mtr (R) ( p = .0005). Smoking habit was associated with a higher prevalence of par (C) ( p = .02). A noteworthy association was observed between the presence of msr (D) gene and the use of antibiotics ( p = .014). Conclusions Our findings reveal an enrichment of antimicrobial resistance genes in the oropharynx of MSM. These insights could aid in the development of screening programs and antimicrobial stewardship initiatives targeting populations at heightened risk of pharyngeal gonorrhea.

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Antimicrobial resistance determinants in the oropharyngeal microbiome of ‘men having sex with men’ attending an sexually transmitted infection clinic

Djusse,

Gaspari,

Morselli

et al. 2024

Int J STD AIDS

View full text Add to dashboard Cite

show abstract

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Inhibitory Activity of Antibacterial Mouthwashes and Antiseptic Substances against Neisseria gonorrhoeae

Cited by 1 publication

References 19 publications

Antimicrobial resistance determinants in the oropharyngeal microbiome of ‘men having sex with men’ attending an sexually transmitted infection clinic

Antimicrobial resistance determinants in the oropharyngeal microbiome of ‘men having sex with men’ attending an sexually transmitted infection clinic

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