Inhibitory activity of chitosan nanoparticles against Cryptosporidium parvum oocysts

Ahmed, Shahira A.; El-Mahallawy, Heba S.; Karanis, Panagiotis

doi:10.1007/s00436-019-06364-0

Cited by 30 publications

(29 citation statements)

References 63 publications

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“…Tannins bind proteins to mucous surfaces rendering them less permeable with poor absorption due to the protective coating of coagulated protein, making the expulsion of parasites easier [43] . The conjugation of C. molmol into the CsNFs permitted the adsorption of C. molmol to the surface of the wall of the oocysts [47,48] , contributing to a shift in its integrity and permeability leading to their damage [49] . However, the additive effects of C. molmol and CsNFs conjugation observed in the present study may be due to the different synergistic mechanisms of action of both substances.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic potential of Commiphora molmol extract loaded on chitosan nanofibers against experimental cryptosporidiosis

Fahmy

Aly

et al. 2021

Parasitologists United Journal

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Plant extracts have advantages over prescription drugs; not only are they more cost-effective, easier to produce and process, more available, and more effective, but they also tend to have fewer adverse effects [11] . Conjugation of plant extracts into nanostructured drug delivery systems, enhanced their therapeutic properties, potency, and safety of the active entity [12,13] . C. molmol, known in folklore medicine as Myrrh, is one of the effective plants

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Section: Discussionmentioning

confidence: 99%

Therapeutic potential of Commiphora molmol extract loaded on chitosan nanofibers against experimental cryptosporidiosis

Fahmy

Aly

et al. 2021

Parasitologists United Journal

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“…In giardiasis, combination nanotherapy with silver, chitosan and curcumin nanoparticles have been shown to effectively clear the parasites from intestine and stool without any adverse effects [116]. Chitosan as nanosuspension has also shown lethal effects on Cryptosporidium oocysts [117]. Similarly, silver nanoparticles have also been shown to effectively reduced oocyst burden by triggering IFN-γ, without any adverse events as seen with standard therapeutic options [118].…”

Section: Nano-medicinal Approachmentioning

confidence: 99%

Molecular Medicines for Parasitic Diseases

Singh¹

2021

Methods in Molecular Medicine

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Being the cause for significant amount of morbidities and mortalities, parasitic diseases remain the major challenge for the healthcare community due to the limitations associated with the current chemotherapeutics. Drug discovery/invention can be achieved by collaborative efforts of biotechnologists and pharmacists for identifying potential candidates and successfully turn them into medicine for improving the healthcare system. Although molecular medicine for disease intervention is still in its infancy, however, significant research works and successful trials in short span of time have made it broadly accepted among the scientific community. This chapter identifies different molecular medicine approaches for dealing with parasites that have been coming up on the horizon with the new technological advances in bioinformatics and in the field of omics. With the better understanding of the genomics, molecular medicine field has not only raised hopes to deal with parasitic infections but also accelerated the development of personalized medicine. This will provide a targeted approach for identifying the druggable targets and their pathophysiological importance for disease intervention.

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“…In addition, low-molecular-weight chitosan oligosaccharide inhibited bacterial activity, biofilm formation and hemolytic activity of Staphylococcus aureus [209]. In vivo and in vitro models showed that chitosan reduced Cryptosporidium parvum oocyst viability and Cryptosporidium parvum multiplication, respectively [210,211]. Furthermore, chitosan oligosaccharide killed Candida auris in both nonaggregative form (NCPF 8973) and aggregative form (NCPF 8978) [212].…”

Section: Infectious Diseasementioning

confidence: 99%

Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications

Satitsri

Muanprasat

2020

Molecules

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Chitin is a long-chain polymer of N-acetyl-glucosamine, which is regularly found in the exoskeleton of arthropods including insects, shellfish and the cell wall of fungi. It has been known that chitin can be used for biological and biomedical applications, especially as a biomaterial for tissue repairing, encapsulating drug for drug delivery. However, chitin has been postulated as an inducer of proinflammatory cytokines and certain diseases including asthma. Likewise, chitosan, a long-chain polymer of N-acetyl-glucosamine and d-glucosamine derived from chitin deacetylation, and chitosan oligosaccharide, a short chain polymer, have been known for their potential therapeutic effects, including anti-inflammatory, antioxidant, antidiarrheal, and anti-Alzheimer effects. This review summarizes potential utilization and limitation of chitin, chitosan and chitosan oligosaccharide in a variety of diseases. Furthermore, future direction of research and development of chitin, chitosan, and chitosan oligosaccharide for biomedical applications is discussed.

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Inhibitory activity of chitosan nanoparticles against Cryptosporidium parvum oocysts

Cited by 30 publications

References 63 publications

Therapeutic potential of Commiphora molmol extract loaded on chitosan nanofibers against experimental cryptosporidiosis

Therapeutic potential of Commiphora molmol extract loaded on chitosan nanofibers against experimental cryptosporidiosis

Molecular Medicines for Parasitic Diseases

Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications

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