Inhibitory activity of S-PRG filler on collagen-bound MMPs and dentin matrix degradation

Soares, Igor Paulino Mendes; Anselmi, Caroline; Guiné, Isabela; Fernandes, Lídia de Oliveira; Pires, Maria Luiza Barucci Araujo; Costa, Carlos Alberto de Souza; Scheffel, Débora Lopes Salles; Hebling, Josimeri

doi:10.1016/j.jdent.2022.104237

Cited by 15 publications

(7 citation statements)

References 46 publications

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“…It is important to keep in mind that a dentine bridge of 1.5 mm is considered sufficient to limit the negative effects from eluates from dental materials, and with the carious structure above the pulp that will be remineralized with the SDF products, the possible exposure to the dental pulp also becomes more limited. In addition, the SDF products usually work as a step 1 and step 2 protocol, resulting in a more favorable result for cytocompatibility when combined (25,26). Stela Light Cure as a restorative material compared to Riva Light Cure presented a non-significant better cytocompatibility at both time intervals, with the 48 h time interval having a greater cytocompatibility of 57.66% compared to the 27.41% cytocompatibility of Riva Light Cure.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, mixing the two components (steps 1 and 2) of both materials and then exposing the buccal fibroblasts could have been assessed to evaluate their combined effect, but the premise of silver precipitation is still likely considering the current results. The assessment of cytocompatibility for Riva Star and Riva Star Aqua is ideal as per the dentine disc method and therefore presents a clinically relevant cytocompatibility assessment of the materials (26). The use of Stela Light Cure is a suitable material as it showed potential for increased cytocompatibility compared to Riva Light Cure.…”

Section: Discussionmentioning

confidence: 99%

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Comparing cytocompatibility of two fluoride-containing solutions and two resin-based restorative materials—a pilot study

Mulder,

Noordien,

Potgieter

2024

Front. Oral. Health

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BackgroundCytocompatibility should always be considered, especially if the surface of treated carious lesions is close to soft tissue or is accidentally exposed to the oral soft tissue by the clinician.MethodsThe aim of the present study was to compare the cytocompatibility of two fluoride-containing liquids and two resin-containing restorative materials with buccal mucosa fibroblasts. The fluoride-containing materials were silver diamine fluoride and water-based silver fluoride.ResultsThe statistical analysis was completed by comparing the positive control growth of the buccal mucosa fibroblasts to the growth of cells exposed to various materials. The one-way ANOVA with Tukey’s HSD result was completed. All the assessed materials compared to the control wells for both the 24 and 48 h time intervals indicated a significant cytocompatibility result, except for the test wells with Stela (SDI) at the 24 h time interval. There was no significant difference between the step 2 liquids and the two dental materials in cytocompatibility at the 24 h interval. All four materials indicated no significant differences between the cytocompatibility of any dental materials for 48 h.ConclusionThe cytocompatibility assessment for Riva Star and Riva Star Aqua with the direct method in a full dispensing drop is not viable for step 1 of the fluoride-containing liquids. The use of Stela Light Cure is a suitable material that will be in contact with buccal mucosa as it showed potential for increased cytocompatibility compared to Riva Light Cure. Riva Star Aqua is more cytocompatible than Riva Star.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparing cytocompatibility of two fluoride-containing solutions and two resin-based restorative materials—a pilot study

Mulder,

Noordien,

Potgieter

2024

Front. Oral. Health

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“…It has been reported in the dental literature that, matrix metalloproteinases (MMP), as a family of enzymes with the function of degrading the extracellular matrix, adversely affect dental adhesion over time [18,31,32]. Therefore, studies in adhesive dentistry have been focused on enzyme inhibition [33] or biomimetic remineralization strategies [34] to slow down the degradation, in order to reveal more successful adhesion in the long term.…”

Section: Discussionmentioning

confidence: 99%

Three-year clinical performance of direct Restorations using Low Shrinkage Giomer versus Nanohybrid Resin Composite

Toz-Akalin,

Öztürk-Bozkurt,

Kusdemir

et al. 2023

Preprint

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Objectives The objective of this investigation was to compare the clinical performances of nanohybrid and low-shrinkage bioactive resin composites. Materials and methods Totally, 35 pairs of restorations performed with either low-shrinkage bioactive Giomer (Beautifil II LS, Shofu Inc.) or nanohybrid (Clearfil Majesty Posterior) resin composites in 35 patients by two operators using the relevant adhesives: FL-Bond II (Shofu Inc) and Clearfil SE Bond (Kuraray), according to each manufacturer’s instructions. Two clinicians assessed the restorations two weeks after restorative procedures (baseline), after six months, one, two and three years using FDI criteria (Scores 1–5). Data were analyzed using the marginal homogeneity and the McNemar test. Survival Rate was calculated using Kaplan-Meier survival analysis and the survival of the two groups was compared with the Log-Rank test (p = 0.05). Results Mean observation period was 37.7 ± 6.8 months. All restorations completed their 3-years follow up. All criteria were rated mainly with high (1 or 2) scores for quality in both groups. Only one restoration from low-shrinkage Giomer restorative group was accepted as failure due to retention loss of the restorative. Conclusion Over the three-year follow-up, both the Giomer and the nanohybrid resin composite restorations’ performances were similar and clinically acceptable. Clinical relevance Low-shrinkage bioactive material Giomer resin composite exhibited similar clinical performance to the nanohybrid resin composite after three years in service, with both materials displaying minor surface deteriorations at three-year recall. Trial registration Clinical Trial Registration Number: NCT02823769.

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“…Hydroxyproline is a major constituent of dentinal collagen. Degradation of collagen can be detected by the amount of hydroxyproline released [ 41 ]. When demineralized dentin is placed in a buffer solution at 37 °C, dentinal MMPs degrade the collagen network, which reduces its stiffness and results in loss of dry mass containing hydroxyproline [ 13 , 42 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of Salvadora persica on resin-dentin bond stability

Abu-Nawareg,

Abouelseoud,

Zidan

2024

BMC Oral Health

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Background The stability of resin–dentin interfaces is still highly questionable. The aim of this study was to evaluate the effect of Salvadora persica on resin–dentin bond durability. Materials and methods Extracted human third molars were used to provide mid-coronal dentin, which was treated with 20% Salvadora persica extract for 1 min after acid-etching. Microtensile bond strength and interfacial nanoleakage were evaluated after 24 h and 6 months. A three-point flexure test was used to measure the stiffness of completely demineralized dentin sticks before and after treatment with Salvadora persica extract. The hydroxyproline release test was also used to measure collagen degradation by endogenous dentin proteases. Statistical analysis was performed using two-way ANOVA followed by post hoc Bonferroni test and unpaired t-test. P-values < 0.05 were considered statistically significant. Results The use of Salvadora persica as an additional primer with etch-and-rinse adhesive did not affect the immediate bond strengths and nanoleakage (p > 0.05). After 6 months, the bond strength of the control group decreased (p = 0.007), and nanoleakage increased (p = 0.006), while Salvadora persica group showed no significant difference in bond strength and nanoleakage compared to their 24 h groups (p > 0.05). Salvadora persica increased dentin stiffness and decreased collagen degradation (p < 0.001) compared to their controls. Conclusion Salvadora persica extract pretreatment of acid-etched dentin preserved resin–dentin bonded interface for 6 months. Clinical significance Durability of resin-dentin bonded interfaces is still highly questionable. Endogenous dentinal matrix metalloproteinases play an important role in degradation of dentinal collagen within such interfaces. Salvadora persica may preserve resin-dentin interfaces for longer periods of time contributing to greater clinical success and longevity of resin composite restorations.

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Inhibitory activity of S-PRG filler on collagen-bound MMPs and dentin matrix degradation

Cited by 15 publications

References 46 publications

Comparing cytocompatibility of two fluoride-containing solutions and two resin-based restorative materials—a pilot study

Comparing cytocompatibility of two fluoride-containing solutions and two resin-based restorative materials—a pilot study

Three-year clinical performance of direct Restorations using Low Shrinkage Giomer versus Nanohybrid Resin Composite

Effect of Salvadora persica on resin-dentin bond stability

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