Inhibitory Activity of Xanthone Derivatives Isolated from Some Guttiferaeous Plants against DNA Topoisomerases I and II.

DNA strand-scission by phloroglucinols and lignans from heartwood of Garcinia subelliptica Merr. and Justicia plants

“…(Clusiaceae) have been reported (Iinuma et al, 1995;Minami et al, 1996Minami et al, , 1998Fukuyama et al, 1993Fukuyama et al, , 1998. Several xanthones possess inhibitory activity against DNA topoisomerases I and II (Tosa et al, 1997), whereas some xanthone derivatives have antioxidant activities (Minami et al, 1994). In previous papers, we isolated several new terpenoids and phloroglucinols from seeds of G. subelliptica and reported their anti-inflammatory activities (Lin et al, 1996;Chung et al, 1998;Weng et al, 2003aWeng et al, ,b, 2004.…”

Polyisoprenylated benzophenone derivatives from the fruits of Garcinia cambogia and their absolute configuration by quantum chemical circular dichroism calculations

“…3 Garcinol shows antibiotic activity against methicillin-resistant Staphylococcus aureus comparable to that of vancomycin 4 and it inhibits topoisomerases I and II at concentrations comparable to that of etoposide. 5 Furthermore, garcinol has reported to possess antitumor activity against human leukemia HL-60 cells, through cytochrome c release and activation of caspases [6][7][8] and to inhibit histone acetyltransferases and p300/CPB-associated factor, both of which modulate gene expression. 9 Garcinol is also able to suppress colonic aberrant crypt foci (ACF) formation in rats and to modulate tyrosine phosphorylation of FAK and subsequently to induce apoptosis in human colon cancer cells.…”

Cytotoxic Prenylated Xanthones from the Young Fruit of Garcinia mangostana

“…1,2) Studies have been conducted to examine the anticancer properties of the extracts or xanthones obtained from the fruit hulls of this plant species against colon preneoplastic lesions, 3) DNA topoisomerases I and II, 4) human leukemia (HL60, K562, NB4, U937, P3HR1, and Raji), 5,6) hepatoma (HCC36, TONG, HA22T, Hep 3B, HEpG2, and SK-HEp-1), lung (NCI-Hut 125, CH27-LC-1, H2981, and Calu-1), and gastric carcinomas (AZ521, NUGC-3, KATO-III, and AGS), 7) and human breast cancer SKBR3 cells. 8,9) Our interest has been focused on the isolation of structurally interesting prenylated xanthones and the biological activities of intermediates at various stages of fruit maturity.…”