Inhibitory Activity on Xanthine Oxidase and Antioxidant Properties of &amp;lt;i&amp;gt;Teucrium polium&amp;lt;/i&amp;gt;

Boumerfeg, Sabah; Baghiani, Abderrahmane; Djarmouni, Meriem; Ameni, Djamila; Adjadj, Moufida; Belkhiri, Farida; Charef, Noureddine; Khennouf, Seddik; Arrar, Lekhmici

doi:10.4236/cm.2012.31006

Cited by 23 publications

(13 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the degradation rate of β-carotene-linoleate depends on the antioxidant activity of the extracts. According to Boumerfeg et al [ 22 ], the test of linoleic acid oxidation inhibition coupled with β-carotene, appears very useful as a mimetic model of lipid peroxidation in biological membranes. β-carotene-linoleic acid assay determines the inhibition ratios of linoleic acid oxidation as further methods to confirm the anti-lipoperoxidation effects of V. negundo and V. trifolia .…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Polyphenol Contents and Antioxidant Activities between Ethanol Extracts of Vitex negundo and Vitex trifolia L. Leaves by Different Methods

Saklani

Mishra

Chandra

et al. 2017

Plants

View full text Add to dashboard Cite

The in vitro antioxidant potential assay between ethanolic extracts of two species from the genus Vitex (Vitex negundo L. and Vitex trifolia L.) belonging to the Lamiaceae family were evaluated. The antioxidant properties of different extracts prepared from both plant species were evaluated by different methods. DPPH scavenging, nitric oxide scavenging, and β-carotene-linoleic acid and ferrous ion chelation methods were applied. The antioxidant activities of these two species were compared to standard antioxidants such as butylated hydroxytoluene (BHT), ascorbic acid, and Ethylene diamine tetra acetic acid (EDTA). Both species of Vitex showed significant antioxidant activity in all of the tested methods. As compared to V. trifolia L. (60.87–89.99%; 40.0–226.7 μg/mL), V. negundo has been found to hold higher antioxidant activity (62.6–94.22%; IC50 = 23.5–208.3 μg/mL) in all assays. In accordance with antioxidant activity, total polyphenol contents in V. negundo possessed greater phenolic (89.71 mg GAE/g dry weight of extract) and flavonoid content (63.11 mg QE/g dry weight of extract) as compared to that of V. trifolia (77.20 mg GAE/g and 57.41 mg QE/g dry weight of extract respectively). Our study revealed the significant correlation between the antioxidant activity and total phenolic and flavonoid contents of both plant species.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Polyphenol Contents and Antioxidant Activities between Ethanol Extracts of Vitex negundo and Vitex trifolia L. Leaves by Different Methods

Saklani

Mishra

Chandra

et al. 2017

Plants

View full text Add to dashboard Cite

show abstract

“…The results indicate that the ASE improve free radical scavenging activity and reducing capacity regardless of the importance of these activities of the ASE determined in-vitro and these effects may be primarily attributed to the polyphenolic contents. According to the literature, many types of research demonstrate the significant correlation between the measured plasma antioxidant capacity and the total phenol content of plant extracts 25,26,27 . Whereas, in-vivo these activities are limited by several factors such as low bioavailability and metabolic conversion of the absorbed polyphenols (plasma concentration rarely exceeds 1µM) 28 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2019

IJPSR

View full text Add to dashboard Cite

This study aims to evaluate the in-vitro and in-vivo antioxidant activity of different extracts prepared from the aerial parts of Arthrophytum scoparium. Polyphenols flavonoids and tannins contents were determined. The acute toxicity of ASE was carried out based on OECD during two weeks to ascertain the LD 50 . In sub-acute toxicity, a 100, 200 and 400 mg/kg/day extract was orally administrated for 21 days consecutively. The results showed that decoction extract (DEC) was the richest fractions in Polyphenols, flavonoids and tannins content (23.29 mg/GAE, 99.77 mg/QE and 113.33 mg/TAE), respectively. Arthrophytum scoparium hydromethanolic extract (ASE) had the strongest antioxidant activity using DPPH and ABTS scavenging assays with an IC 50 of 0.045 and 0.0017 mg/ml, respectively. Moreover, the β-carotene/linoleic acid bleaching assay showed that ethyl acetate extract (EAE) had the highest inhibiting activity (83.29%). Furthermore, all A. scoparium fractions exhibited a good ferric reducing power. The administrated doses did not undergo changes in general behavior, toxicity or mortality of the tested mice. The LD 50 was found to be superior to 5 g/kg. Daily administration of ASE leads to an increase in GSH level and decreasing the lipid peroxidation in the liver. In-vivo, ASE showed a strong scavenging effect on DPPH and reducing power. In conclusion, A. scoparium extracts exhibited considerable antioxidant effects in-vitro and in-vivo. These findings support the traditional use of this plant as an anti-inflammatory in therapeutics.

show abstract

“…The results showed that quercitin have a stronger scavenger activity compared to rutin, this decrease in activity of rutin may be caused by the blockage of the hydroxyl groups by glycosylation (Rutinose) in carbons of positions 3. 23 . However, in our study, the order of decreasing scavenging activity among the C. calcitrapa extracts was found to be EAE > CrE > ChE, which is not in accordance with the amount of phenolic compounds present in these extracts.…”

Section: In Vitro Antioxidant Activity Dpph Radical Scavenging Activitymentioning

confidence: 99%

The In vivo and in vitro antioxidant and anti-hemolytic effect of Algerian Centaurea calcitrapa L. extracts

Trabsa

Baghiani

Boussoualim

et al. 2020

J. Drug Delivery Ther.

Self Cite

View full text Add to dashboard Cite

In the present study, aerial part of Centaurea calcitrapa L. were extracted with solvent of varying polarity allowed their separation into three main subfractions, the analysis of methanol crud (CrE), chloroform (ChE) and ethyl acetate (EaE) extracts, showed that the EaE contains the highest amount of flavonoids (50,71 ± 0,65 mg Eq / Quercetin g dry extract and 31,96 ± 0,39 mg Eq Rutin / g dry extract). Using DPPH assay, the highest activity was observed with EaE (IC50 = 0,037 ± 0,0006 mg / ml). The β-carotene / linoleic acid bleaching assay revealed that the extracts have a very important antioxidant activity. The results showed that CrE has the highest antioxidant activity. The antioxidant activity of the CrE is confirmed by an in vivo assay in mice, using two doses: CrD1 (50 mg/kg/day) and CrD2 (100 mg/kg/day) during 21 days. Total antioxidant capacity of plasma and red blood cells was measured. The half-life (HT50), which corresponds to 50% of cell lysis was calculated, the results showed that both groups treated with plant extract had a protective effect against erythrocytes hemolysis (CrD2: HT50= 167,3 ± 3,72 min). The CrD2 group showed a strong scavenging activity using DPPH assay (51,64 ± 5,24 %), higher than that of Vit C group (38,92 ± 1,72 %). All results confirmed that the extracts have a dose dependent effect on the growth of overall antioxidant defenses. These results support the use of this plant against anti-inflammatory diseases in traditional medicine. Keywords: Centaurea calcitrapa L., in vivo-antioxidant activity, DPPH, hemolysis, flavonoids.

show abstract

Inhibitory Activity on Xanthine Oxidase and Antioxidant Properties of <i>Teucrium polium</i>

Cited by 23 publications

References 56 publications

Comparative Evaluation of Polyphenol Contents and Antioxidant Activities between Ethanol Extracts of Vitex negundo and Vitex trifolia L. Leaves by Different Methods

Comparative Evaluation of Polyphenol Contents and Antioxidant Activities between Ethanol Extracts of Vitex negundo and Vitex trifolia L. Leaves by Different Methods

Untitled

The In vivo and in vitro antioxidant and anti-hemolytic effect of Algerian Centaurea calcitrapa L. extracts

Contact Info

Product

Resources

About