Inhibitory and excitatory effects of adenosine antagonists on spontaneous locomotor activity in mice

Florio, Chiara; Rosati, Anna; Traversa, U.; Vertua, R.

doi:10.1016/s0024-3205(97)00099-4

Cited by 16 publications

(14 citation statements)

References 24 publications

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“…Here, the animals delayed the time to cross chambers (from the white to black compartment), which is contradictory to the cited work, which leads us to suggest that DPCPX induced depressant locomotor effects in zebrafish, as in rodents when exposed to low doses (Florio et al, 1997). At high doses, a hyperlocomotor effect of this antagonist was registered in rodents (Florio et al, 1997;Kuzmin et al, 2006). However, when DPCPX was given after training, the latency to cross chambers in the test session increased similarly to the control group and prevented CBD effects.…”

Section: Fig Dcontrasting

confidence: 95%

“…DPCPX (6 mg/L) used with adult zebrafish in the light/dark box paradigm decreased the time in the white compartment, while no alteration on distance traveled was registered (Stewart et al, 2011). Here, the animals delayed the time to cross chambers (from the white to black compartment), which is contradictory to the cited work, which leads us to suggest that DPCPX induced depressant locomotor effects in zebrafish, as in rodents when exposed to low doses (Florio et al, 1997). At high doses, a hyperlocomotor effect of this antagonist was registered in rodents (Florio et al, 1997;Kuzmin et al, 2006).…”

Section: Fig Dcontrasting

confidence: 83%

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Caffeine protects against memory loss induced by high and non-anxiolytic dose of cannabidiol in adult zebrafish (Danio rerio)

Nazario

Antonioli

Capiotti

et al. 2015

Pharmacology Biochemistry and Behavior

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Section: Fig Dcontrasting

confidence: 95%

Section: Fig Dcontrasting

confidence: 83%

Caffeine protects against memory loss induced by high and non-anxiolytic dose of cannabidiol in adult zebrafish (Danio rerio)

Nazario

Antonioli

Capiotti

et al. 2015

Pharmacology Biochemistry and Behavior

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“…High expression of CD73 in the striatum suggests involvement of A2A receptors in mediating the observed locomotor phenotype. Indeed, adenosine A2A receptor antagonists produce motor effects in animal models [28], [29] and there is considerable interaction between adenosine and dopamine receptors in the striatum that subsequently influences spontaneous locomotor activity [28], [30]–[32].…”

Section: Discussionmentioning

confidence: 99%

CD73 Is a Major Regulator of Adenosinergic Signalling in Mouse Brain

et al. 2013

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CD73 (ecto-5’-nucleotidase) is a cell surface enzyme that regulates purinergic signalling by desphosphorylating extracellular AMP to adenosine. 5′-nucleotidases are known to be expressed in brain, but the expression of CD73 and its putative physiological functions at this location remain elusive. Here we found, using immunohistochemistry of wild-type and CD73 deficient mice, that CD73 is prominently expressed in the basal ganglia core comprised of striatum (caudate nucleus and putamen) and globus pallidus. Furthermore, meninges and the olfactory tubercle were found to specifically express CD73. Analysis of wild type (wt) and CD73 deficient mice revealed that CD73 confers the majority of 5’-nucleotidase activity in several areas of the brain. In a battery of behavioural tests and in IntelliCage studies, the CD73 deficient mice demonstrated significantly enhanced exploratory locomotor activity, which probably reflects the prominent expression of CD73 in striatum and globus pallidus that are known to control locomotion. Furthermore, the CD73 deficient mice displayed altered social behaviour. Overall, our data provide a novel mechanistic insight into adenosinergic signalling in brain, which is implicated in the regulation of normal and pathological behaviour.

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“…To investigate further the role of adenosine A 1 receptors, we tested the e¤ect of the adenosine A 1 receptor selective antagonist CPT at a dose that was previously found to a¤ect spontaneous locomotor activity in mice (Florio et al 1997). In the light / dark test, CPT at 100 nmol / kg signiÞcantly increased the latency of exploration of the lit box and reduced the number of transitions.…”

Section: Discussionmentioning

confidence: 99%

“…In a recent study, we found that in CD1 mice, the adenosine agonists NECA and 2-chloro-N 6 -cyclopentyladenosine (CCPA) increased spontaneous locomotor activity at low doses and reduced it at high doses (Florio et al 1997). Interestingly, stimulation of locomotion has also been observed after administration of benzodiazepines at subdepressant doses (Bruns et al 1983).…”

Section: Introductionmentioning

confidence: 99%

Adenosine A 1 receptors modulate anxiety in CD1 mice

et al. 1998

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The effect of the selective adenosine A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA) was investigated in CD1 mice by the elevated plus-maze and the light/dark test, two models for measuring anxiety in rodents. CCPA, administered i.p., had an anxiolytic effect at 0.3 nmol/kg in the elevated plus-maze and at 1 nmol/kg in the light/dark test. Brain levels of 22 nM were found after administration of 100 nmol/kg CCPA, as measured by ex vivo binding experiments. These values are consistent with the occupancy of adenosine A1 but not A2 receptors by CCPA, and suggest that the anxiolytic-like action of CCPA may be mediated by centrally located adenosine A1 receptors. Both CPT, a selective adenosine A1 receptor antagonist, and IBMX, a non-selective adenosine antagonist, had an anxiogenic effect in the two tests. It is thus possible that purinergic neurons may be involved in the tonic modulation of affective state in mice.

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Inhibitory and excitatory effects of adenosine antagonists on spontaneous locomotor activity in mice

Cited by 16 publications

References 24 publications

Caffeine protects against memory loss induced by high and non-anxiolytic dose of cannabidiol in adult zebrafish (Danio rerio)

Caffeine protects against memory loss induced by high and non-anxiolytic dose of cannabidiol in adult zebrafish (Danio rerio)

CD73 Is a Major Regulator of Adenosinergic Signalling in Mouse Brain

Adenosine A 1 receptors modulate anxiety in CD1 mice

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