Inhibitory C-type lectin receptors in myeloid cells

Redelinghuys, Pierre; Brown, Gordon D.

doi:10.1016/j.imlet.2010.10.005

Cited by 48 publications

(37 citation statements)

References 222 publications

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“…Specific ligands for MICL are currently undefined; however, soluble MICL was used to probe for potential ligands in many different tissues revealing binding in bone marrow, thymus, heart, spleen and kidney. This widespread recognition suggests that MICL may play a role in regulation of homeostasis [33, 79, 80]. MICL is also expressed on acute myeloid leukaemia (AML) cells, where it is used as a marker and having a potential role in AML therapeutics.…”

Section: The Dectin-1 Clustermentioning

confidence: 99%

C-Type Lectin-Like Receptors of the Dectin-1 Cluster: Ligands and Signaling Pathways

Plato

Willment

Brown

2013

International Reviews of Immunology

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178

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Innate immunity is constructed around genetically encoded receptors that survey the intracellular and extracellular environments for signs of invading microorganisms. These receptors recognise the invader and through complex intracellular networks of molecular signaling, they destroy the threat whilst instructing effective adaptive immune responses. Many of these receptors, like the Toll-like receptors in particular, are well-known for their ability to mediate downstream responses upon recognition of exogenous or endogenous ligands; however, the emerging family known as the C-type lectin-like receptors contains many members that have a huge impact on immune and homeostatic regulation. Of particular interest here are the C-type lectin-like receptors that make up the Dectin-1 cluster and their intracellular signaling motifs that mediate their functions. In this review, we aim to draw together current knowledge of ligands, motifs and signaling pathways, present downstream of Dectin-1 cluster receptors, and discuss how these dictate their role within biological systems.

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Section: The Dectin-1 Clustermentioning

confidence: 99%

C-Type Lectin-Like Receptors of the Dectin-1 Cluster: Ligands and Signaling Pathways

Plato

Willment

Brown

2013

International Reviews of Immunology

Self Cite

178

188

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“…They play a crucial role in enabling NK cells to discriminate between self and nonself [32,33]. The CD94-NKG2 C-type lectin receptors have been found to be expressed predominantly on the surface of a majority of NK cells and on subsets of CD8 + T cells [34] and to be involved in NK cellmediated recognition of MHC I molecules [35].…”

Section: Cd94-nkg2 C-type Lectin Receptor Complexmentioning

confidence: 99%

Introductory Chapter: A Brief Overview on Natural Killer Cells

Aribi¹

2017

Natural Killer Cells

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Additional information is available at the end of the chapter IntroductionNatural killer (NK) cells represent about 5-15% of circulating lymphocytes [1] and belong to the innate immune system, in particular due to their invariant antigen receptors. Morphologically, as opposed to "small lymphocytes," most of them are typically large azurophilic granules containing lymphocytes (LGL) [2], characterized by high cytoplasmic:nuclear ratio. They have initially been referred to as k or null lymphocytes (non-B and non-T cells), with the highest cytotoxic capacity [3,4], because they lack conventional T-cell membrane markers and the surface membrane immunoglobulin (smIg) [5,6]. NK cells mediate resistance against intracellular pathogens, mainly viral-infected, bacteria-infected and protozoa-infected cells, and have the potential to restrain cancer and metastasis. They are also able to contribute to the activation and the regulation of the immune responses, as well as the orientation of adaptive immune responses [7,8]. More recently, NK cells were recognized as a subtype of type 1 innate lymphoid cells (ILC1), which express the transcription factor T-box expressed in T cells (T-bet), and deined by the production of the T helper cell type 1 (Th1)-associated cytokine interferon gamma (IFN-γ) and the inability to produce Th2 cell-associated and Th17 cell-associated cytokines [9]. As a result of collective work, this book has therefore the ultimate purpose to address the most fundamental aspects of NK cells, as well as their clinical applications for cancer immunotherapy. Lineage of NK cellsNK cells constitute a third lymphoid line derived from a common T-cell and B-cell bone marrow precursor. Unlike T cells, NK cells do not have a specialized diferentiating organ, are matured inside of bone marrow, and can develop even in athymic mice. The acquisition of their functions

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“…Of particular interest are the single CTLD-containing extracellular receptors of dectin-1 and dectin-2 clusters which associate with signaling adaptor or possess integral intracellular signaling domains. The number of extracellular carbohydrate recognition domain (CRD) and their cellular localization classifies CRLs to type-I transmembrane, type-II transmembrane, and soluble CRLs [53]. CRLs recognize carbohydrate ligands, lipids and proteins by mechanisms not well understood.…”

Section: C-type Lectin-like Receptors (Clrs)mentioning

confidence: 99%

Immune Recognition in Lung Diseases: Basic Research and Clinical Application

Alvarado¹,

Arce²

2016

Clin Infect Immun

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Respiratory diseases are among the leading causes of morbidity and mortality in the world population. Our understanding of the molecular mechanisms leading to recognition of infectious pathogens and harmful endogenous signals by the innate immune system and the adaptive immune system has improved significantly in recent decades. There is increased evidence of the key role of the immune system with its pattern recognition receptors (PRRs) in infectious and non-infectious lung diseases. The PRRs are a family of sensors able to sense different microbial molecules as well as endogenous molecules which are released by the host tissue damage. The commitment of PRRs is a prerequisite for the initiation of immune and inflammatory response to infection and tissue injury that may be beneficial or harmful. The PRRs are germ-line encoded, evolutionarily conserved molecules and consist of Toll-like receptors, NOD-like receptors, RIG-I-like receptors, C-type lectin-like receptors and cytosolic DNA sensors. This review summarizes the prominent role of transmembrane and cytosolic PRRs in the pathogenesis of infectious and non-infectious lung diseases. The PRRs and their signals represent promising targets for prophylactic and therapeutic strategies in various lung diseases.

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Inhibitory C-type lectin receptors in myeloid cells

Cited by 48 publications

References 222 publications

C-Type Lectin-Like Receptors of the Dectin-1 Cluster: Ligands and Signaling Pathways

C-Type Lectin-Like Receptors of the Dectin-1 Cluster: Ligands and Signaling Pathways

Introductory Chapter: A Brief Overview on Natural Killer Cells

Immune Recognition in Lung Diseases: Basic Research and Clinical Application

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