Inhibitory CARs fail to protect from immediate T cell cytotoxicity

BTLA and PD-1 signals attenuate TCR-mediated transcriptomic changes

“…We have recently shown that primary human T cells overexpressing PD-1 and BTLA were strongly inhibited in the presence of the ligands to these immune checkpoints. 62 Human T cells engineered to co-express matched levels of PD-1 and BTLA might be useful to study and compare transcriptomic regulation mediated by PD-1 and BTLA signals in primary CD4 and CD8 T cells.…”